Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A 61-year-old woman was referred to surgery for incidentally found colonic polyps during a health examination. Physical examination revealed widespread eczematous skin lesion without pruritus in the perianal and vulvar area. Abdominopelvic computed tomography showed an approximately 4-cm-sized, soft tissue lesion in the right perianal area. Inguinal lymph node dissection and Mils’ operation extended to perianal and perivulvar skin was performed. Histologically, the anal canal lesion was composed of mucin-containing signet ring cells, which were similar to those found in Pagetoid skin lesions. It was diagnosed as an anal canal signet ring cell carcinoma (SRCC) with perianal and vulvar Pagetoid spread and bilateral inguinal lymph node metastasis. Anal canal SRCC is rare, and the current case is the third reported case in the English literature. Seven additional cases were retrieved from the world literature. Here, we describe this rare case of anal canal SRCC with perianal Pagetoid spread and provide a literature review.
Abstract
A 61-year-old woman was referred to surgery for incidentally found colonic polyps during a health examination. Physical examination revealed widespread eczematous skin lesion without pruritus in the perianal and vulvar area. Abdominopelvic computed tomography showed an approximately 4-cm-sized, soft tissue lesion in the right perianal area. Inguinal lymph node dissection and Mils’ operation extended to perianal and perivulvar skin was performed. Histologically, the anal canal lesion was composed of mucin-containing signet ring cells, which were similar to those found in Pagetoid skin lesions. It was diagnosed as an anal canal signet ring cell carcinoma (SRCC) with perianal and vulvar Pagetoid spread and bilateral inguinal lymph node metastasis. Anal canal SRCC is rare, and the current case is the third reported case in the English literature. Seven additional cases were retrieved from the world literature. Here, we describe this rare case of anal canal SRCC with perianal Pagetoid spread and provide a literature review.
참고문헌 (19)
- Inamura K, "Prognostic significance and molecular features of signet-ring cell and mucinous components in colorectal carcinoma", Ann Surg Oncol, 22, pp.1226~1235 (2015)
- Chu PG, "Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and colon", Am J Clin Pathol, 121, pp.884~892 (2004)
- Uchigasaki S, "Circumanal Paget’s disease which was complicated by anus cancers after 15 years", Skin Cancer, 7, pp.254~258 (1992)
- Ioannidis O, "Primary signet ring cell anal adenocarcinoma", J Gastrointest Cancer, 43(Suppl 1), pp.168~170 (2012)
- Terada T, "Primary pure signet-ring cell carcinoma of the anus: a case report with immunohistochemical study", Endoscopy, 46(Suppl 1 UCTN), pp.E347~ (2014)
- Lopes Filho LL, "Mammary and extramammary Paget’s disease", An Bras Dermatol, 90, pp.225~231 (2015)
- Morihisa A, "An autopsy case of anal canal cancer showing Paget’s disease as the first sign", Jpn J Clin Dermatol, 53, pp.758~760 (1999)
- Nagano Y, "Rectal signet ring cell carcinoma associated with perianal Paget’s disease: report of a case", J Jpn Surg Assoc, 60, pp.473~476 (1999)
- Naganuma H, "An autopsy case of anal canal cancer (signet ring cell carcinoma)accompanied with perianal Pagetoid spread", Jpn J Diagn Pathol, 21, pp.129~132 (2004)
- Nishimura H, "A case of anal canal cancer presenting a pagetoid phenomenon in the perianal lesion", Jpn J Clin Dermatol, 58, pp.674~677 (2004)
- Yoshitani S, "A case of anal canal carcinoma with systemic lymph node metastases successfully treated by bevacizumab+mFOLFOX6 therapy", Gan To Kagaku Ryoho, 36, pp.2229~2231 (2009)
- Ikezawa F, "Pagetoid spread with anal canal poorly differentiated adenocarcinoma: a case report", Jpn J Gastroenterol Surg, 43, pp.678~684 (2010)
- Moritani Y, "A case of anal gland carcinoma accompanied by Pagetoid spread", Nippon Daicho Komonbyo Gakkai Zasshi, 62, pp.121~126 (2009)
- Welton ML, "WHO Classification of Tumours of the Digestive System", pp.183~193 (2010), WHO
- Grelck KW, "Signet ring cell perianal paget disease: loss of MUC2 expression and loss of signet ring cell morphology associated with invasive disease", Am J Dermatopathol, 33, pp.616~620 (2011)
- Ohnishi T, "The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extramammary Paget’s disease", Br J Dermatol, 142, pp.243~247 (2000)
- Ogino S, "CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer", Gut, 58, pp.90~96 (2009)
- Kang H, "A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum", Dis Colon Rectum, 48, pp.1161~1168 (2005)
- Shridhar R, "Anal cancer: current standards in care and recent changes in practice", CA Cancer J Clin, 65, pp.139~162 (2015)