Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases
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Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.
Abstract
Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.
참고문헌 (12)
- Rosen PP, "Rosen’s breast pathology" (2001), Lippincott Williams & Wilkins
- Rosenblum MK, "Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein", Am J Surg Pathol, 10, pp.237~245 (1986)
- Koenig C, "Carcinoma arising in microglandular adenosis : an immunohistochemical analysis of 20 intraepithelial and invasive neoplasms", Int J Surg Pathol, 8, pp.303~315 (2000)
- Khalifeh IM, "Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma", Am J Surg Pathol, 32, pp.544~552 (2008)
- Shui R, "Matrix-producing carcinoma of the breast in the Chinese population: a clinicopathological study of 13 cases", Pathol Int, 61, pp.415~422 (2011)
- Shui R, "Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature", Breast J, 15, pp.653~656 (2009)
- Marenholz I, "S100 proteins in mouse and man : from evolution to function and pathology(including an update of the nomenclature)", Biochem Biophys Res Commun, 322, pp.1111~1122 (2004)
- Lehmann BD, "Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies", J Clin Invest, 121, pp.2750~2767 (2011)
- Geyer FC, "Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma", Histopathology, 55, pp.732~743 (2009)
- Shin SJ, "Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma", Am J Surg Pathol, 33, pp.496~504 (2009)
- Geyer FC, "Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis", Histopathology, 60, pp.E115~E130 (2012)
- Tsang JY, "Microglandular adenosis: a prime suspect in triple-negative breast cancer development", J Pathol, 239, pp.129~132 (2016)