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Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: its updated diagnostic criteria, preoperative cytologic diagnoses and impact on the risk of malignancy

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Due to the extremely indolent behavior, a subset of noninvasive encapsulated follicular variant papillary thyroid carcinomas has been classified as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)” since 2016 and is no longer considered carcinoma. Since the introduction of this new terminology, changes and refinements have been made in diagnostic criteria. Initially, the incidence of NIFTP was estimated substantial. However, the reported incidence of NIFTP varies greatly among studies and regions, with higher incidence in North American and European countries than in Asian countries. Thus, the changes in the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) differ inevitably among regions. Because more conservative surgery is recommended for NIFTPs, distinguishing NIFTPs from papillary thyroid carcinomas in preoperative fine-needle aspiration cytology became one of the major concerns. This review will provide comprehensive overview of updates on diagnostic criteria, actual incidence and preoperative cytologic diagnoses of NIFTP, and its impact on the ROM in TBSRTC.

Abstract

Due to the extremely indolent behavior, a subset of noninvasive encapsulated follicular variant papillary thyroid carcinomas has been classified as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)” since 2016 and is no longer considered carcinoma. Since the introduction of this new terminology, changes and refinements have been made in diagnostic criteria. Initially, the incidence of NIFTP was estimated substantial. However, the reported incidence of NIFTP varies greatly among studies and regions, with higher incidence in North American and European countries than in Asian countries. Thus, the changes in the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) differ inevitably among regions. Because more conservative surgery is recommended for NIFTPs, distinguishing NIFTPs from papillary thyroid carcinomas in preoperative fine-needle aspiration cytology became one of the major concerns. This review will provide comprehensive overview of updates on diagnostic criteria, actual incidence and preoperative cytologic diagnoses of NIFTP, and its impact on the ROM in TBSRTC.

참고문헌 (49)

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관련 논문AI추천

Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features and Its Impact on the Risk of Malignancy in the Bethesda System for Reporting Thyroid Cytopathology: An Institutional Experience곽윤진, 김미림, 김정은, 김현정, 박소연, 정율리대한병리학회 · Journal of Pathology and Translational Medicine2018 · 제52권 제3호A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea곽정자, 김장희, 김희성, 나희영, 박소연, 박지현, 서자영, 석재연, 송동은, 정찬권, 차윤진, 표주연, 홍순원대한병리학회 · Journal of Pathology and Translational Medicine2019 · 제53권 제6호Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions고재수, 공준석, 김정순, 명재경, 박선후, 설혜실, 송우탁, 신명순, 이승숙, 하화정, 한강희대한병리학회 · Journal of Pathology and Translational Medicine2018 · 제52권 제2호Recent topics on thyroid cytopathology: reporting systems and ancillary studiesAyana Suzuki, Mitsuyoshi Hirokawa대한병리학회 · Journal of Pathology and Translational Medicine2025 · 제59권 제4호Fine needle aspiration cytology diagnoses of follicular thyroid carcinoma: results from a multicenter study in Asia나희영, 박소연, 신수진, 정찬권, Andrey Bychkov, Jen-Fan Hang, Kaori Kameyama, Kennichi Kakudo, Miyoko Higuchi, Shinya Satoh, Shipra Agarwal, Yun Zhu, Zhiyan Liu대한병리학회 · Journal of Pathology and Translational Medicine2024 · 제58권 제6호Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes정찬권, Agnes Stephanie Harahap대한병리학회 · Journal of Pathology and Translational Medicine2024 · 제58권 제6호

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