A sinonasal yolk sac tumor in an adult
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Yolk sac tumors (YSTs), which are also called endodermal sinus tumors, are malignant tumors of germ cell origin. These tumors usually occur in the gonads, but 20% of cases have been reported at extragonadal sites. The head and neck is a rarely affected region that accounts for just 1% of all malignant tumors of germ cell origin. In addition, YSTs arise mostly in childhood. We present a rare pathologically pure case of primary adult YST in the sinonasal area. A 45-year-old male patient presented with a rapidly growing mass in the nasal cavity, which caused nasal obstruction and bloody post-nasal drip. The histopathologic features indicated pure YST, and immunohistochemical analysis revealed positive reactivity for Sal-like protein 4 and alpha-fetoprotein. Herein, we discuss the clinical, radiologic, and histologic features of this YST and review other cases of sinonasal YST in adults.
Abstract
Yolk sac tumors (YSTs), which are also called endodermal sinus tumors, are malignant tumors of germ cell origin. These tumors usually occur in the gonads, but 20% of cases have been reported at extragonadal sites. The head and neck is a rarely affected region that accounts for just 1% of all malignant tumors of germ cell origin. In addition, YSTs arise mostly in childhood. We present a rare pathologically pure case of primary adult YST in the sinonasal area. A 45-year-old male patient presented with a rapidly growing mass in the nasal cavity, which caused nasal obstruction and bloody post-nasal drip. The histopathologic features indicated pure YST, and immunohistochemical analysis revealed positive reactivity for Sal-like protein 4 and alpha-fetoprotein. Herein, we discuss the clinical, radiologic, and histologic features of this YST and review other cases of sinonasal YST in adults.
참고문헌 (16)
- Bernbeck B, "Germ cell tumors of the head and neck : report from the MAKEI Study Group", Pediatr Blood Cancer, 52, pp.223~226 (2009)
- Ronchi A, "Extragonadal germ cell tumors : not just a matter of location : a review about clinical, molecular and pathological features", Cancer Med, 8, pp.6832~6840 (2019)
- Khan S, "Pure yolk sac tumor of testis in an adult : a rare occurrence", J Postgrad Med, 60, pp.351~353 (2014)
- Nogales FF, "Yolk sac tumours revisited : a review of their many faces and names", Histopathology, 60, pp.1023~1033 (2012)
- Agaimy A, "SMARCB1(INI-1)-deficient sinonasal carcinoma : a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity", Am J Surg Pathol, 41, pp.458~471 (2017)
- Manivel C, "Transitional(cylindric)cell carcinoma with endodermal sinus tumor-like features of the nasopharynx and paranasal sinuses : clinicopathologic and immunohistochemical study of two cases", Arch Pathol Lab Med, 110, pp.198~202 (1986)
- Filho BC, "Yolk sac tumor in the nasal cavity", Am J Otolaryngol, 29, pp.250~254 (2008)
- Mishra A, "Endodermal sinus tumor of the paranasal sinuses", Head Neck, 30, pp.539~543 (2008)
- Thomas J, "Sinonasal teratocarcinosarcoma with yolk sac elements : a neoplasm of somatic or germ cell origin?", Ann Diagn Pathol, 15, pp.135~139 (2011)
- Mei X, "Sinonasal yolk sac(endodermal sinus)tumor in an adult female : a case report and review of the literature", APMIS, 123, pp.810~814 (2015)
- Zamecnik M, "Sinonasal SMARCB1(INI1)deficient carcinoma with yolk sac tumor differentiation : report of a case and comparison with INI1 expression in gonadal germ cell tumors", Int J Surg Pathol, 26, pp.245~249 (2018)
- Wang P, "A case of primary sinonasal yolk sac tumor", Clin Nucl Med, 45, pp.908~909 (2020)
- Oosterhuis JW, "Human germ cell tumours from a developmental perspective", Nat Rev Cancer, 19, pp.522~537 (2019)
- Hodgson A, "Somatically derived yolk sac tumor of the ovary in a young woman", Int J Gynecol Pathol, 40, pp.296~300 (2021)
- Heerema-McKenney A, "Congenital teratoma : a clinicopathologic study of 22 fetal and neonatal tumors", Am J Surg Pathol, 29, pp.29~38 (2005)
- McKenney JK, "Extragonadal germ cell tumors : a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations", Adv Anat Pathol, 14, pp.69~92 (2007)