Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Myoferlin is a multifunctional protein expressed in various normal and cancer cells, with novel oncogenic roles being newly discovered. Recently, correlations have been found between myoferlin expression and unfavorable prognosis in various carcinomas. This study investigated the prognostic role of myoferlin expression in papillary thyroid carcinoma (PTC), specifically that associated with nodal metastasis. Methods: We collected clinicopathological data and PTC tissues from 116 patients who had been admitted to Gyeongsang National University Hospital in 2010. Immunohistochemical analysis was performed on surgical specimen-derived tissue microarray blocks. Myoferlin expression was graded, and the relationship between expression level and pathological features of tumors based on the American Joint Committee on Cancer staging system was evaluated. Results: Of the 116 patient samples, 100 cases exhibited positive myoferlin expression. Higher grade of myoferlin expression was correlated with lower T category group (p = .010). Presence of lymph node metastasis was determined to be significantly correlated with low-grade myoferlin expression (p = .019), with no significant difference between pN1a and pN1b tumors. Conclusions: Our study revealed an adverse correlation between myoferlin expression and pathological features of PTC, evidence of the potential prognostic role of myoferlin in PTC lymph node metastasis.
Abstract
Background: Myoferlin is a multifunctional protein expressed in various normal and cancer cells, with novel oncogenic roles being newly discovered. Recently, correlations have been found between myoferlin expression and unfavorable prognosis in various carcinomas. This study investigated the prognostic role of myoferlin expression in papillary thyroid carcinoma (PTC), specifically that associated with nodal metastasis. Methods: We collected clinicopathological data and PTC tissues from 116 patients who had been admitted to Gyeongsang National University Hospital in 2010. Immunohistochemical analysis was performed on surgical specimen-derived tissue microarray blocks. Myoferlin expression was graded, and the relationship between expression level and pathological features of tumors based on the American Joint Committee on Cancer staging system was evaluated. Results: Of the 116 patient samples, 100 cases exhibited positive myoferlin expression. Higher grade of myoferlin expression was correlated with lower T category group (p = .010). Presence of lymph node metastasis was determined to be significantly correlated with low-grade myoferlin expression (p = .019), with no significant difference between pN1a and pN1b tumors. Conclusions: Our study revealed an adverse correlation between myoferlin expression and pathological features of PTC, evidence of the potential prognostic role of myoferlin in PTC lymph node metastasis.
참고문헌 (21)
- "Cancer", 1998, 2638~2648
- Amin MB, "AJCC cancer staging manual", pp.873~890 (2017), Spinger
- Harwood J, "Significance of lymph node metastasis in differentiated thyroid cancer", Am J Surg, 136, pp.107~112 (1978)
- Zaydfudim V, "The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma", Surgery, 144, pp.1070~1077 (2008)
- Nixon IJ, "The impact of nodal status on outcome in older patients with papillary thyroid cancer", Surgery, 156, pp.137~146 (2014)
- Haugen BR, "2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer : the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer", Thyroid, 26, pp.1~133 (2016)
- Sugitani I, "A novel classification system for patients with PTC : addition of the new variables of large(3 cm or greater)nodal metastases and reclassification during the follow-up period", Surgery, 135, pp.139~148 (2004)
- Wang LY, "Central lymph node characteristics predictive of outcome in patients with differentiated thyroid cancer", Thyroid, 24, pp.1790~1795 (2014)
- Jeon MJ, "The prognostic value of the metastatic lymph node ratio and maximal metastatic tumor size in pathological N1a papillary thyroid carcinoma", Eur J Endocrinol, 168, pp.219~225 (2013)
- Lee J, "Prognostic significance of the number of metastatic lymph nodes to stratify the risk of recurrence", World J Surg, 38, pp.858~862 (2014)
- Doherty KR, "Normal myoblast fusion requires myoferlin", Development, 132, pp.5565~5575 (2005)
- Demonbreun AR, "Myoferlin is required for insulin-like growth factor response and muscle growth", FASEB J, 24, pp.1284~1295 (2010)
- Leung C, "Expression of myoferlin in human and murine carcinoma tumors: role in membrane repair, cell proliferation, and tumorigenesis", Am J Pathol, 182, pp.1900~1909 (2013)
- Volakis LI, "Loss of myoferlin redirects breast cancer cell motility towards collective migration", PLoS One, 9, pp.e86110~ (2014)
- Li R, "Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion", PLoS One, 7, pp.e39766~ (2012)
- Song DH, "Myoferlin expression in non-small cell lung cancer : Prognostic role and correlation with VEGFR-2 expression", Oncol Lett, 11, pp.998~1006 (2016)
- Wang WS, "iTRAQ-based quantitative proteomics reveals myoferlin as a novel prognostic predictor in pancreatic adenocarcinoma", J Proteomics, 91, pp.453~465 (2013)
- Song DH, "Prognostic role of myoferlin expression in patients with clear cell renal cell carcinoma", Oncotarget, 8, pp.89033~89039 (2017)
- Hermanns C, "The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma", Oncogene, 36, pp.3464~3476 (2017)
- 김민혜, "Myoferlin Expression and Its Correlation with FIGO Histologic Grading in Early-Stage Endometrioid Carcinoma", Journal of Pathology and Translational Medicine, 52(2), pp.93~97 (2018), 대한병리학회[DOI]
- Uhlen M, "Proteomics : tissuebased map of the human proteome", Science, 347, pp.1260419~ (2015)