본문 바로가기
KERD
논문KCI 등재

Aneurysmal bone cyst: a review

Elham Nasri|John David Reith
대한병리학회|2023.03|Journal of Pathology and Translational Medicine|제57권 제2호|pp. 81-87

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

Aneurysmal bone cystBone cystUSP6 gene
주제분류병리학

초록

Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the vertebrae. Secondary, ABClike changes can complicate a variety of other benign and malignant primary bone neoplasms, including giant cell tumor, fibrous dysplasia, and osteosarcoma. About two-third of primary ABCs have a rearrangement of the USP6 gene, which is not present in the ABC-like changes that occur secondary to other primary bone tumors (i.e., secondary ABC). Primary ABC of bone carries a variable but generally high rate of local recurrence. This paper provides an overview of the pathophysiology, clinical presentation, radiographic and pathologic findings, treatment, and prognosis of ABC.

Abstract

Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the vertebrae. Secondary, ABClike changes can complicate a variety of other benign and malignant primary bone neoplasms, including giant cell tumor, fibrous dysplasia, and osteosarcoma. About two-third of primary ABCs have a rearrangement of the USP6 gene, which is not present in the ABC-like changes that occur secondary to other primary bone tumors (i.e., secondary ABC). Primary ABC of bone carries a variable but generally high rate of local recurrence. This paper provides an overview of the pathophysiology, clinical presentation, radiographic and pathologic findings, treatment, and prognosis of ABC.

참고문헌 (37)

  1. Zehetgruber H, "Prevalence of aneurysmal and solitary bone cysts in young patients", Clin Orthop Relat Res, 439, pp.136~143 (2005)
  2. Leithner A, "Aneurysmal bone cyst : a population based epidemiologic study and literature review", Clin Orthop Relat Res, (363), pp.176~179 (1999)
  3. Czerniak B, "Dorfman and Czerniak’s bone tumors, E-Book" (2015), Elsevier Health Sciences
  4. Martinez V, "Aneurysmal bone cyst : a review of 123cases including primary lesions and those secondary to other bone pathology", Cancer, 61, pp.2291~2304 (1988)
  5. Vergel De Dios AM, "Aneurysmal bone cyst : a clinicopathologic study of 238 cases", Cancer, 69, pp.2921~2931 (1992)
  6. Kransdorf MJ, "Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging", AJR Am J Roentgenol, 164, pp.573~580 (1995)
  7. Althof PA, "Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization", Mod Pathol, 17, pp.518~525 (2004)
  8. Ye Y, "TRE17", USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB, 2010, pp.29, 3619~3629
  9. Oliveira AM, "USP6-induced neoplasms : the biologic spectrum of aneurysmal bone cyst and nodular fasciitis", Hum Pathol, 45, pp.1~11 (2014)
  10. Weber MG, "An Uncommon presentation of an uncommon bone tumor: a case study of a pathologic fracture of an intertrochanteric aneurysmal bone cyst", Cureus, 11, pp.e6461~ (2019)
  11. Novais EN, "Aneurysmal bone cyst of the cervical spine in children", J Bone Joint Surg Am, 93, pp.1534~1543 (2011)
  12. Papagelopoulos PJ, "Aneurysmal bone cyst of the spine : management and outcome", Spine (Phila Pa 1976), 23, pp.621~628 (1998)
  13. Revel MP, "Aneurysmal bone cysts of the jaws : CT and MR findings", J Comput Assist Tomogr, 16, pp.84~86 (1992)
  14. Mahnken AH, "Aneurysmal bone cyst: value of MR imaging and conventional radiography", Eur Radiol, 13, pp.1118~1124 (2003)
  15. Bahk WJ, "Differential diagnostic value of “blue reticulated chondroid-like material” in aneurysmal bone cysts: a classic histopathologic analysis of 215 cases", Am J Clin Pathol, 143, pp.823~829 (2015)
  16. Wang JC, "Clinicopathological and molecular characterisation of USP6-rearranged soft tissue neoplasms: the evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity", Histopathology, 78, pp.676~689 (2021)
  17. Sekoranja D, "Novel ASAP1-USP6, FAT1-USP6, SAR1A-USP6, and TNC-USP6 fusions in primary aneurysmal bone cyst", Genes Chromosomes Cancer, 59, pp.357~365 (2020)
  18. Guseva NV, "Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst", Genes Chromosomes Cancer, 56, pp.266~277 (2017)
  19. Blackburn PR, "RNA sequencing identifies a novel USP9X-USP6 promoter swap gene fusion in a primary aneurysmal bone cyst", Genes Chromosomes Cancer, 58, pp.589~594 (2019)
  20. Warren M, "Gene fusions PAFAH1B1-USP6 and RUNX2-USP6 in aneurysmal bone cysts identified by next generation sequencing", Cancer Genet, 212-213, pp.13~18 (2017)
  21. Mantilla JG, "Characterization of novel USP6 gene rearrangements in a subset of so-called cellular fibroma of tendon sheath", Mod Pathol, 34, pp.13~19 (2021)
  22. Svajdler M, "Fibro-osseous pseudotumor of digits and myositis ossificans show consistent COL1A1-USP6 rearrangement : a clinicopathological and genetic study of 27 cases", Hum Pathol, 88, pp.39~47 (2019)
  23. Patel NR, "USP6 activation in nodular fasciitis by promoter-swapping gene fusions", Mod Pathol, 30, pp.1577~1588 (2017)
  24. Nakayama S, "Ubiquitin-specific peptidase 6 (USP6)-associated fibroblastic", myofibroblastic tumors : evolving concepts, 2021, pp.18, 93~101
  25. Lee JC, "Soft tissue special issue : giant cell-rich lesions of the head and neck region", Head Neck Pathol, 14, pp.97~108 (2020)
  26. Campanacci M, "Unicameral and aneurysmal bone cysts", Clin Orthop Relat Res, (204), pp.25~36 (1986)
  27. Mankin HJ, "Aneurysmal bone cyst : a review of 150 patients", J Clin Oncol, 23, pp.6756~6762 (2005)
  28. Flont P, "A comparison of cyst wall curettage and en bloc excision in the treatment of aneurysmal bone cysts", World J Surg Oncol, 11, pp.109~ (2013)
  29. Shiels WE 2nd, "Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate : a preliminary report", Clin Orthop Relat Res, 471, pp.2675~2683 (2013)
  30. Lange T, "Denosumab : a potential new and innovative treatment option for aneurysmal bone cysts", Eur Spine J, 22, pp.1417~1422 (2013)
  31. Cornelis F, "Bisphosphonate therapy for unresectable symptomatic benign bone tumors : a long-term prospective study of tolerance and efficacy", Bone, 58, pp.11~16 (2014)
  32. Falappa P, "Aneurysmal bone cysts : treatment with direct percutaneous Ethibloc injection : long-term results", Cardiovasc Intervent Radiol, 25, pp.282~290 (2002)
  33. Varshney MK, "Is sclerotherapy better than intralesional excision for treating aneurysmal bone cysts?", Clin Orthop Relat Res, 468, pp.1649~1659 (2010)
  34. Rossi G, "Selective arterial embolization of 36 aneurysmal bone cysts of the skeleton with N-2-butyl cyanoacrylate", Skeletal Radiol, 39, pp.161~167 (2010)
  35. Bush CH, "Percutaneous radionuclide ablation of axial aneurysmal bone cysts", AJR Am J Roentgenol, 194, pp.W84~W90 (2010)
  36. Gibbs CP Jr, "Aneurysmal bone cyst of the extremities. Factors related to local recurrence after curettage with a high-speed burr", J Bone Joint Surg Am, 81, pp.1671~1678 (1999)
  37. van de Luijtgaarden AC, "Metastatic potential of an aneurysmal bone cyst", Virchows Arch, 455, pp.455~459 (2009)

관련 논문AI추천

Primary Aneurysmal Bone Cyst in the Iliac Bone: A Case Report권석현, 김채근대한고관절학회 · Hip and Pelvis2014 · 제26권 제3호삼피질골의 분절성형 골이식을 통한 거골 거대 동맥류성 골낭종의 치료 1예: 증례 보고김갑래, 김동현, 이승진, 이효범대한족부족관절학회 · 대한족부족관절학회지2021 · 제25권 제4호Secondary Aneurysmal Bone Cystic Change of the Chondroblastoma, Mistaken for a Primary Aneurysmal Bone Cyst in the Patella이화성, 정진화대한슬관절학회 · Knee Surgery and Related Research2014 · 제26권 제1호Langerhans Cell Histiocytosis With Secondary Aneurysmal Bone Cyst in a 9-Year-Old Boy’s Femur: A Case ReportHong Hyeok Jin, Kim Ji Young, Kim Taehyeon, Ryu Young Jin대한자기공명의과학회 · Investigative Magnetic Resonance Imaging2023 · 제27권 제4호Benign fibrous histiocytoma with cystic change of the femur; a case report김나라, 문승규, 박정아대한자기공명의과학회 · Investigative Magnetic Resonance Imaging2016 · 제20권 제4호동맥류성 골낭종으로 오인된 거골에 발생한 연골모세포종: 증례 보고박지수, 서진수, 최준영대한족부족관절학회 · 대한족부족관절학회지2019 · 제23권 제1호

이 간행물의 다른 논문 (7건)

Significance of tumor-associated neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinomaWael Abdo Hassan, Hany Lotfy, Rehab Ibrahim Ali, Ahmed Kamal ElBanna, Noha Noufal, Mohamed El-Assmypp. 88-94Current state of cytopathology residency training: a Korean national survey of pathologists조의주, 이교영, 김완섭, 윤혜경, 김태정, 최현주pp. 95-101Postmortem lung and heart examination of COVID-19 patients in a case series from JordanAdnan Said Abbas, Maram Abdaljaleel, Isra Tawalbeh, Malik Sallam, Amjad Bani Hani, Imad M. Al-Abdallat, Baheth Al Omari, Sahar Al-Mustafa, Hasan Abder-Rahman, Mahmoud Zureigat, Mousa A. Al-Abbadipp. 102-112Clinicopathologic significance of the delta-like ligand 4, vascular endothelial growth factor, and hypoxia-inducible factor-2α in gallbladder cancer김경미, 장기택, 장원철, 김준식, 박수진pp. 113-122Unsuspected systemic Epstein-Barr virus–positive T-cell lymphoma of childhood diagnosed at autopsy in a potential homicide caseErik A. Ranheim, Jamie E. Kallan, Daniel J. Robbinspp. 123-127
원문 보기