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논문KCI 등재

위축된 상악구치부 임플란트 식립을 위한 다양한 골재생 효과의조직형태학적 비교연구

Comparative histomorphologic study of regenerated bone for dental implant placement in the atrophied posterior maxilla

김성민|박영욱|김지혁|김세정
대한구강악안면외과학회 (Korean Association Of Oral And Maxillofacial Surgeons)|2007.02|대한구강악안면외과학회지 (Journal of the Korean Association of Oral and Maxillofacial Surgeons)|제33권 제1호|pp. 28-39

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주제분류치의학

초록

Abstract

The purpose of this study is to evaluate the regenerative capacity of reconstruction in the atrophied posterior maxilla by comparing bone graft procedures and alveolar distraction osteogenesis (ADO) techniques. We performed the autogenous iliac bone graft (AGB group, 5 specimens in 3 patients), and the combination (Mixed group, 3 specimens in 3 patients) of the autogenous and deproteinized bovine bone (Bio-Oss., Geistlich Co., Switzerland) as the ratio of 2:1 in the sinus floor elevation procedures. ADO procedures using TRACK. (KLS Martin Co., Germany) were also performed to augment vertical alveolar height in atrophied posterior maxilla (ADO group, 5 specimens in 4 patients). Newly generated bone tissues were obtained with the 2.0mm diameter trephine bur (3i Co., USA) during implant fixture installation after 5-7 months. Routine histolomorphological observation, immunodot blot assay for quantitative evaluation, and immunohistochemical staining with antibodies to MMP-1, -9, -10, TIMP-1, -2, and BMP-2, -4 were all carried out. Lamellar bone formation was well shown in all specimens and new bone formations of ADO group increased than those of other procedures. In immunohistochemical staining, the strong expression of BMP-2 was shown in all specimens, and immunodot blot assay showed that bone formation is accompanied by the good induction of factors associated with angiogenesis and appeared more increased amount of osteogenic and angiogenic factors in ADO group. ADO is the most effective technique for new bone formation compared to sinus floor elevation with autogenous or mixed bone graft in the atrophied posterior maxilla. In the quantitative immunodot blot assay, the regenerated bone after ADO showed more increased products of VEGF, BMP-2, PCNA and MMP-1 than those after the other procedures, and these findings were able to be confirmed by immunohistochemical stainings.

참고문헌 (26)

  1. "Alveolar distraction osteogenesis vs. vertical guided bone regeneration for the correction of vertically deficient edentulous ridges: A 1-3-year prospective study on humans", 15, pp.82~95 (2004)
  2. "Distraction osteogenesis of the alveolar ridge: a review of the literature", 9, pp.321~327 (2004)
  3. "Histomorphometrical analysis of bone formed in human maxillary sinus floor elevations grafted with OP-1 device, demineralized bone matrix of autogenous bone. Comparison with non-grafted sites in a series of case reports", 10, pp.499~509 (1999)
  4. "Bovine-HA spongiosa blocks and immediate implant placement in sinus augmentation procedures. Histopathological and histomorphometric observations on different histological stainings in 10 consecutive patients", 13, pp.420~427 (2002)
  5. "Grafting materials in repair and restoration", pp.83~101 (1999), Quintessence Publishing Inc
  6. "Report of the sinus consensus conference of 1996", 13, pp.11~45 (1998)
  7. "Sinus grafting with porous hydroxyapatite", pp.79~94 (1999), Quintessence Publishing Inc
  8. "Maxillary sinus augmentation for endosteal implants: Organized alternative treatment plans", pp.49~58
  9. "Endosteal implants and iliac crest grafts to restore severely resorbed totally edentulous maxillae-a retrospective study. J Oral Implantol 1994", pp.100~110
  10. "Extraoral autogenous donor bone grafts for endosteal implants", pp.521~538 (1999), C.V. Mosby
  11. "A new method of inserting endosseous implants in totally atrophic maxillae. J Craniomaxillofac Surg 1989", pp.299~305
  12. "Sinus grafting with calvarial bone", pp.107~116 (1999), Quintessence Publishing Inc 1999
  13. "Efficacy of bovine bone mineral for alveolar augmentation: a human histologic study", 14, pp.775~783 (2003)
  14. "Comparative histomorphologic study of regenerated bone for the dental implant placement in the atrophied posterior maxilla", pp.134~135 (2005)
  15. "Comparative histomorphologic study of the distracted bone and grafted autogenous bone in maxillary sinus for the recovery of atrophied posterior maxilla", 26, pp.147~ (2004)
  16. "Distraction osteogenesis of the nasal and antral osseous floor to enhance alveolar height", 62, pp.123~130 (2004)
  17. "Matrix metalloproteinases and their inhibitors in bone remodeling following distraction osteogenesis of the sheep mandible", 30, pp.208~212 (2002)
  18. "Distribution of matrix metalloproteinases and their inhibitor, TIMP-1, in developing human osteophytic bon", 191, pp.39~48 (1997)
  19. "Matrix metalloproteinases and TIMP-1 localization at sites of osteogenesis in the craniofacial region of the rabbit embryo", 242, pp.177~187 (1995)
  20. "mRNA expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in interface tissue around implants in loosening total hip arthroplasty", 32, pp.611~617 (1996)
  21. "Does the sheep mandible relapse following lengthening by distraction osteogenesis?", 28, pp.251~257 (2000)
  22. "Temporal and spatial expression of bone morphogenetic protein-2, -4, and -7 during distraction osteogenesis in rabbits", 27, pp.453~459 (2000)
  23. "Effects of locally applied vascular endothelial growth factor(VEGF) and VEGF-inhibitor to the rabbit tibia during distraction osteogenesis", 21, pp.335~340 (2003)
  24. "Expression of angiogenic factors during distraction osteogenesis", 33, pp.889~898 (2003)
  25. "Angiogenesis and mineralization during distraction osteogenesis", pp.435~447 (2002)
  26. Tatum HJ, "Maxillary and sinus implant reconstructions", Dent Clin North Am, 30, pp.207~229 (1986)

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