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히알룬산젤이 구강 창상 치유에 미치는 영향

The effects of hyaluronic acid gel on the healing of oral mucosa

최정한|홍종락|신창훈|김형진
대한구강악안면외과학회 (Korean Association Of Oral And Maxillofacial Surgeons)|2007.08|대한구강악안면외과학회지 (Journal of the Korean Association of Oral and Maxillofacial Surgeons)|제33권 제4호|pp. 359-366

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참고문헌

주제분류치의학

초록

Abstract

Purpose: In spite of various advantages of hyaluronic acid in wound healing, there are few research about wound healing process and period in oral and maxillofacial surgery. So, We evaluated the effects of local application of hyaluronic acid gel on wound healing of the oral mucosa using this animal model. Materials and methods: Young adult New Zealand White rabbits, weighting between 2.5 and 3.0kg, were used. Almost uniform round ulcerscould be created on the gingival of the rabbits by chemical injury with acetic acid. In experimental group, hyaluronic acid gel was applied daily until the wounds healed and in control group, ulcer lesion was not any treatment. The lengths of ulcers were measured the longest and shortest axes of the ulcers and calculated the areas of ulcer. For histological examination, specimens were made, and observed under a light microscope. Results: The results showed that the number of fibroblasts, new blood vessels and the epithelial thickness from experimental group was higher than from control group. Hyaluronic acid promoted proliferation of the fibroblast, keratinocytes isolated from gingival tissue of rabbits in vitro. Topical application of hyaluronic acid accelerated healing of ulcers created in rabbits. Conclusion: The hyaluronic acid may be effective for wound healing of oral mucosal lesions.

참고문헌 (29)

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관련 논문AI추천

구강내 외과적 창상 치유에서 0.2% hyaluronic acid gel의 유효성에 대한 이중 맹검 연구김재윤, 배광학, 이종호, 이진용대한구강악안면외과학회 · 대한구강악안면외과학회지2008 · 제34권 제2호백서 두개부 결손부에 이식된 이종골 치유과정에 히알루론산이 미치는 영향에 관한 연구민승기, 조이수대한구강악안면외과학회 · 대한구강악안면외과학회지2002 · 제28권 제3호치은부에 이식한 이중인공진피의 조직학적 치유김민정, 김영준, 김옥수, 정현주대한치주과학회 · Journal of Periodontal & Implant Science2003 · 제33권 제2호히알루론산이 골 형성에 미치는 영향에 관한 실험적 연구김수남, 민승기, 유용욱, 조용민대한구강악안면외과학회 · 대한구강악안면외과학회지2002 · 제28권 제3호배양된 구강점막 각화상피세포가 누드마우스 피부 창상 치유에 미치는 효과김진, 김남희, 김현실, 차인호대한구강악안면외과학회 · 대한구강악안면외과학회지2004 · 제30권 제4호키토산이 치은섬유아세포에 미치는 영향김옥수, 정현주대한치주과학회 · Journal of Periodontal & Implant Science2002 · 제32권 제1호

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