본문 바로가기
KERD
논문KCI 등재

가토에서 하악골 신장술이 악관절에 미치는 영향

The Change of the Temporomandibular Joint after Experimental Distraction of Mandibular Ramus in Rabbit

김경욱|김철환|임승규
대한구강악안면외과학회 (Korean Association Of Oral And Maxillofacial Surgeons)|2008.10|대한구강악안면외과학회지 (Journal of the Korean Association of Oral and Maxillofacial Surgeons)|제34권 제5호|pp. 543-549

1

조회

0

다운로드

0

인용

0

참고문헌

주제분류치의학

초록

Abstract

Distraction osteogenesis is a commonly used technique for mandibular lengthening, but changes in the temporomandibular joint(TMJ) have not been well documented. The TMJ is one of the most complex joint in the body and is composed of a fibrous surface layer, a proliferative zone, hypertrophic cartilage, and bone. The shape and role of the TMJ change and modify during a person’s life-time. Possible complications that can arise after mandibular distraction include failure of the formation, failure of callus, infection, disturbance of TMJ and of occlusion. However, there are only a few reports on changes in the TMJ as a result of distraction osteogenesis. Hence, the goal of this study was to evaluate the change of the TMJ after experimental distraction of mandibular ramus in rabbit. We studied histological changes of mandibular condyle, articular disk and retrodiscal tissue, and also examined the collagen I gene expression and MMP-1 gene expression. The results were as follows. 1. In the histological staining, experimental condylar surface showed more thick fibrous articular layer and proliferative layer, compared with the control condyle and experimental articular disc showed thick and dense collagen fibers compared with the control disc. 2. In the collagen I and MMP-1 gene RT-PCR analysis, experimental discs showed increased collagen I expression compared with the control disc, while MMP-1 gene expression was decreased compared with the control disc. The retrodiscal tissue was almost equal expressions of the collagen I and MMP-1 genes compared with the control retrodiscal tissue. These findings suggest that histological and biomolecular changes occur in condyles and discs after unilateral mandibular distraction osteogenesis.

참고문헌 (42)

  1. Codvilla A, "On the means of lengthening the lower limbs, The muscles and tissues which are shortened through deformity", Am J Orthop Surg, 2, pp.353~369 (1905)
  2. Ilizarov GA, "Basic principles of transosseous compression and distraction osteogenesis", Orthop Tranumatol Protez, 32, pp.7~15 (1971)
  3. Illizarov GA, "The tension-stress effect on the genesis and growth of tissue: part 1, The influence of stability of fixation and soft tissue preservation", Clin.Orthop, 238, pp.249~281 (1989)
  4. Illizarov GA, "The tension-stress effect on the genesis and growth of tissue: part 2, The influence of the rate and frequency of distraction", Clin. Orthop, 239, pp.263~285 (1989)
  5. Synder CC, "Mandibular lengthening by gradual distraction. Preliminary report", Plas Reconstr Surg, 51, pp.506~508 (1973)
  6. McCarthy J, "Plastic Surgery. Craniofacial Microsomia. Vol. 4" (1990), Philadelphia, WB Saunders Co.,
  7. 권경환, "외과적 하악 정중부 골신장술", 대한구강악안면외과학회지, 30(6), pp.516~525 (2004), 대한구강악안면외과학회
  8. McCarthy JG, "The role of distraction osteogenesis in the reconstruction of the mandible in unilateral craniofacial microsomia", Clin Plast Surg, 21, pp.625~ (1994)
  9. 권준경, "가토의 하악골에서 골신장기 동안 반복 골신장술이 골형성에 미치는 효과", 대한구강악안면외과학회지, 32(3), pp.241~249 (2006), 대한구강악안면외과학회
  10. 조영철, "성견의 골신장술에서 골절단술시 재조합 인간 골형성 단백질-7적용에 따른 가골반응과Osteocalcin 발현도에 대한 연구", 대한구강악안면외과학회지, 32(4), pp.317~326 (2006), 대한구강악안면외과학회
  11. Block MS, "Bifocal distraction osteogenesis for mandibular defect healing: Case report", J Oral Maxillofac Surg, 54, pp.1365~1370 (1996)
  12. 백성문, "반안면 왜소증 환자에서의 골신장술 : 증례보고", 대한구강악안면외과학회지, 33(5), pp.559~566 (2007), 대한구강악안면외과학회
  13. Polley JW, "Monobloc craniomaxillofacial distraction osteogenesis in a newborn with severe craniofacial synostosis: a preliminary report", J Craniofac Surg, 6, pp.421~423 (1995)
  14. Murray JE, "Analysis and treatment of hemifacial microsomia", Plast Reconstr Surg, 74, pp.186~199 (1984)
  15. Karp NS, "Bone lengthening in the craniofacial skeleton", Ann Plastic Surg, 24, pp.231~237 (1990)
  16. Paley D, "Problems, obstacles, and complications of limb lengthening by the Ilizarov technique", Clin Orthop, 250, pp.81~87 (1990)
  17. Karaharju-Suvanto T, "Distraction osteogenesis of the mandible: An experimental study on sheep", J Oral Maxillofac Surg, 21, pp.118~124 (1992)
  18. Karp NS, "Membranous bone lengthening: A serial histologic study", An Plast Surg, 29, pp.2~9 (1992)
  19. Block MS, "Changes in the inferior alveolar nerve following mandibular lengthening in the dog using distraction osteogenesis", J Oral Maxillofac Surg, 51, pp.652~659 (1993)
  20. Aronson J, "Mechanical forces as predictors of healing during tibial lengthening by distraction osteogenesis", Clin Orthop, 301, pp.73~81 (1994)
  21. Troulis MJ, "Endoscopic mandibular osteotomy, and placement and activation of a semiburied distractor", J Oral Maxillofac Surg, 57, pp.1110~1119 (1999)
  22. Troulis MJ, "Effects of latency and rate on bone formation in a porcine mandibular distraction model", J Oral Maxillofac Surg, 58, pp.507~512 (2000)
  23. Castaňo FJ, "Proliferation of masseter myocytes after distraction osteogenesis of the porcine mandible", J Oral Maxillofac Surg, 59, pp.302~310 (2001)
  24. Costantino PD, "Segmental mandibular regeneration by distraction osteogenesis", Arch Otolaryngol Head Neck Surg, 116, pp.535~541 (1990)
  25. Aronson J, "Experimental healing of distraction osteogenesis comparing metaphyseal with diaphyseal sites", Clin Orthop Rel Res, 301, pp.25~29 (1994)
  26. Ten Cate AR, "The temporomandibular joint" (1985), St louis, Mosby
  27. Copray J, "Effects of compressive forces on proliferation and matrix synthesis in mandibular condylar cartilage of the rat in vitro", Archs Oral Biol, 30, pp.299~304 (1985)
  28. Copray J, "An in-vitro system for studying the effect of variable compressive forces on the mandibular condylar cartilage of the rat", Archs Oral Biol, 30, pp.305~311 (1985)
  29. Stewart KJ, "Mandibular distraction osteo genesis: A comparison of distraction rates in the rabbit model", J Craniomaxillofac Surg, 26, pp.43~51 (1998)
  30. Greg F, "Long-Term Effect of Mandibular Midline Distraction Osteogenesis on the Status of the Temporomandibular Joint, Teeth, Periodontal Structures and Neurosensory Function", Oral Maxiiiofac Surg, 57, pp.1419~1425 (1999)
  31. Mankin HJ, "Current concepts review The response of articular cartilage to mechanical injury", J Bone and Joint Surg, 64, pp.460~466 (1982)
  32. McNamara Jr JA, "Histologic analysis of temporomandibular joint adaptation to protrusive function in young adult rhesus monkeys(macaca mulatta)", Am J Orthod, 82, pp.288~298 (1986)
  33. Petra T, "Changes in the Condyle and Disc in Response to Distraction Osteogenesis of the Minipig Mandible", J Oral Maxillofac Surg, 60, pp.1327~1333 (2002)
  34. Samcbukov ML, "Biomechanical considerations of mandibular lengthening and widening by gradual distraction using a computer model", J Oral Maxillofac Surg, 56, pp.51~59 (1998)
  35. Nakamura E, "Knee articular cartilage injury in leg lengthening ; histologic studies in rabbits", Acta Orthop Scand, 64, pp.437~440 (1993)
  36. Nakai H, "The influence of compressive loading on growth of cartilage of the mandibular condyle in vitro", Archs Oral Biol, 43, pp.505~515 (1998)
  37. Gloria A, "Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human", Type I Collagen J. Biol. Chem, 277, pp.4223~4231 (2002)
  38. Karsenty G, "Regulation of type I collagen genes expression", Int Rev Immunol, 12, pp.177~185 (1995)
  39. Karl H, "Matrix Remodeling Expression in Anulus Cells Subjected to Increased Compressive Load", 30, pp.1122~1126 (2005)
  40. Gross J, "Collagenolytic activity in amphibian tissues: a tissue culture assay", Proc Natl Acad Sci U S A, 48, pp.1014~1022 (1962)
  41. Eisen A, "Human skin collagenase. Isolation and mechanism of attack on the collagen molecule", Biochim Biophys Acta, 151, pp.637~645 (1968)
  42. Remacle AG, "Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP", Oncogene, 25, pp.5648~5655 (2006)

관련 논문AI추천

가토의 하악골에서 골신장기 동안 반복 골신장술이 골형성에 미치는 효과권준경, 박홍주, 유선열대한구강악안면외과학회 · 대한구강악안면외과학회지2006 · 제32권 제3호가토 하악골에서 신연 골형성술시 Osteonectin의 발현김동준, 송현철, 지유진대한구강악안면외과학회 · 대한구강악안면외과학회지2004 · 제30권 제5호백서 하악골에서 신연골형성술시 신장력과 수축력 복합적용후의 조직반응김욱규, 박봉수, 신상훈, 이광호, 정인교대한구강악안면외과학회 · 대한구강악안면외과학회지2002 · 제28권 제2호백서 하악골에서 신연골형성술시 압축력의 효능에 관한 실험적 연구강항립, 김욱규, 김철훈, 신상훈, 정인교대한구강악안면외과학회 · 대한구강악안면외과학회지2004 · 제30권 제5호집토끼 하악골에서 신연 골형성술시 BMP-2,-4의 발현김상우, 송현철, 지유진대한구강악안면외과학회 · 대한구강악안면외과학회지2004 · 제30권 제3호가토 하악골에서 신연 골형성술시 제 I형 및 II형 교원질의 발현강대실, 송현철, 지유진대한구강악안면외과학회 · 대한구강악안면외과학회지2004 · 제30권 제4호

이 간행물의 다른 논문 (10건)

DNA 염기손상 치유유전자의 변이와 두경부암 발생 위험성최병준, 윤병욱, 오정환pp. 509-517구강편평상피암종에서 DCC 유전자의 역할김경욱, 한세진, 고성규pp. 518-524구강 편평상피암종에서 CDH-13 유전자의 promoter methylation에 대한 연구이문주, 김경욱, 한세진pp. 525-531고농도 포도당 환경에서 EMD(Enamel Matrix Derivatives)가 인간 치주인대 세포와 뼈모세포양 세포(MC3T3-E1)에 미치는 영향이백수, 김선욱, 권용대, 주성숙pp. 532-536양측성 하악지 시상분할술을 이용한 악교정 수술시술 후 교합력과 근전도 변화최용관, 김경욱, 황대용, 이성규pp. 537-542
원문 보기