Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanoticbenign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. Materials and Methods: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology,treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method. Results: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment waspossible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survivalrate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%. Conclusion: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosisand adequate surgery may result in improved overall survival.
Abstract
Objectives: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanoticbenign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. Materials and Methods: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology,treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method. Results: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment waspossible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survivalrate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%. Conclusion: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosisand adequate surgery may result in improved overall survival.
참고문헌 (26)
- Conley J, "Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma)", Cancer, 28, pp.914~936 (1971)[DOI]
- Magro CM, "Unusual variants of malignant melanoma", Mod Pathol, 19(Suppl 2), pp.S41~S70 (2006)[DOI]
- Feng Z, "Incidence and survival of desmoplastic melanoma in the United States, 1992-2007", J Cutan Pathol, 38, pp.616~624 (2011)[DOI]
- Edge S, "AJCC cancer staging manual" (2010), Springer
- 김욱규, "구강내 악성흑색종에 대한 임상연구", 대한구강악안면외과학회지, 34(6), pp.611~615 (2008), 대한구강악안면외과학회
- Batsakis JG, "Desmoplastic melanoma of the maxillary alveolus", J Oral Surg, 37, pp.107~109 (1979)
- Chen JH, "Desmoplastic amelanotic melanoma of palate: a case report with immunohistochemistry and electron microscopic studies", Zhonghua Ya Yi Xue Hui Za Zhi, 8, pp.80~89 (1989)
- Jain S, "Desmoplastic malignant melanoma and its variants. A study of 45 cases", Am J Surg Pathol, 13, pp.358~373 (1989)[DOI]
- Kurihara K, "Desmoplastic malignant melanoma of the gingiva", Oral Surg Oral Med Oral Pathol, 74, pp.201~205 (1992)[DOI]
- Devaraj VS, "Desmoplastic melanoma: a clinico-pathological review", Br J Plast Surg, 45, pp.595~598 (1992)[DOI]
- Manganaro AM, "Oral melanoma: case reports and review of the literature", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 80, pp.670~676 (1995)[DOI]
- Ueta E, "Desmoplastic malignant melanoma of the gingiva: case report and review of the literature", Eur J Cancer B Oral Oncol, 32B, pp.423~427 (1996)
- Kilpatrick SE, "Desmoplastic malignant melanoma of the oral mucosa. An underrecognized diagnostic pitfall", Cancer, 78, pp.383~389 (1996)[DOI]
- Kavanagh BD, "Desmoplastic malignant melanoma of the palatal alveolar mucosa: sustained disease-free survival after surgery and postoperative radiotherapy", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89, pp.465~470 (2000)[DOI]
- Prasad ML, "Primary mucosal desmoplastic melanoma of the head and neck", Head Neck, 26, pp.373~377 (2004)[DOI]
- 최가원, "잇몸에 발생한 원발성 점막의 결합조직형성흑색종- 1예 보고 -", Journal of Pathology and Translational Medicine, 40(6), pp.456~460 (2006), 대한병리학회
- Ramani P, "Desmoplastic malignant melanoma of alveolus: a rare entity", Oral Oncol Extra, 42, pp.291~294 (2006)[DOI]
- Koseoglu RD, "Primary mucosal desmoplastic melanoma of the gingiva", Turk J Med Sci, 39, pp.483~490 (2009)
- Jou A, "Oral desmoplastic melanoma mimicking inflammatory hyperplasia", Gerodontology, 29, pp.e1163~e1167 (2012)[DOI]
- Smyth EC, "Treatment of locally recurrent mucosal melanoma with topical imiquimod", J Clin Oncol, 29, pp.e809~e811 (2011)[DOI]
- Belgaumi UI, "Oral malignant melanoma: a case report of an unusual clinical and histologic presentation", Dent Res J (Isfahan), 10, pp.404~407 (2013)
- [URL]
- Sortino-Rachou AM, "Primary oral melanoma: population-based incidence", Oral Oncol, 45, pp.254~258 (2009)[DOI]
- Chang AE, "The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society", Cancer, 83, pp.1664~1678 (1998)[DOI]
- Hicks MJ, "Oral mucosal melanoma: epidemiology and pathobiology", Oral Oncol, 36, pp.152~169 (2000)[DOI]
- Paulo LF, "Primary amelanotic mucosal melanoma of the oronasal region: report of two new cases and literature review", Oral Maxillofac Surg, 19, pp.333~339 (2015)[DOI]