본문 바로가기
KERD
논문KCI 등재

The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류치의학

초록

Objectives: Melatonin induces human stem cells, converts pre-osteoblasts to mature osteoblasts, and reduces the duration of this transition. However, melatonin itself prevents activation of osteoclasts. Here, we evaluate the role of melatonin in prevention of bisphosphonate-related osteonecrosis of the jaw.Materials and Methods: In this experimental-interventional study, 30 rats were evaluated in 3 groups. The first and second groups received saline and zoledronic acid, respectively, for 4 weeks and the third group received 4 weeks of zoledronic acid and 3 weeks of melatonin simultaneously. First-right-maxillary-molar extraction was performed for all animals, which were sacrificed after 4 weeks of recovery. The extraction sockets were examined histologically for the presence of osteonecrosis, number of osteoclasts and fibroblasts, severity of inflammation, and vascularization. Data were ana-lyzed by chi-square, one-way ANOVA, Tukey, Kruskal–Wallis and Fisher’s exact statistical tests (α=0.05). Results: Osteonecrosis was observed in 20%, 90%, and 70% of the first, second and third groups, respectively (P=0.008). The lowest number of os-teoclasts and fibroblasts was seen in the third group.Conclusion: Melatonin may effectively prevent some undesirable side effects of bisphosphonates. However, further studies are required to confirm the results of this study.

Abstract

Objectives: Melatonin induces human stem cells, converts pre-osteoblasts to mature osteoblasts, and reduces the duration of this transition. However, melatonin itself prevents activation of osteoclasts. Here, we evaluate the role of melatonin in prevention of bisphosphonate-related osteonecrosis of the jaw.Materials and Methods: In this experimental-interventional study, 30 rats were evaluated in 3 groups. The first and second groups received saline and zoledronic acid, respectively, for 4 weeks and the third group received 4 weeks of zoledronic acid and 3 weeks of melatonin simultaneously. First-right-maxillary-molar extraction was performed for all animals, which were sacrificed after 4 weeks of recovery. The extraction sockets were examined histologically for the presence of osteonecrosis, number of osteoclasts and fibroblasts, severity of inflammation, and vascularization. Data were ana-lyzed by chi-square, one-way ANOVA, Tukey, Kruskal–Wallis and Fisher’s exact statistical tests (α=0.05). Results: Osteonecrosis was observed in 20%, 90%, and 70% of the first, second and third groups, respectively (P=0.008). The lowest number of os-teoclasts and fibroblasts was seen in the third group.Conclusion: Melatonin may effectively prevent some undesirable side effects of bisphosphonates. However, further studies are required to confirm the results of this study.

참고문헌 (35)

  1. Ruggiero SL, "American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update", J Oral Maxillofac Surg, 72, pp.1938~1956 (2014)[DOI]
  2. Ikebe T, "Pathophysiology of BRONJ : drug-related osteoclastic disease of the jaw", Oral Sci Int, 10, pp.1~8 (2013)[DOI]
  3. Kaibuchi N, "Multipotent mesenchymal stromal cell sheet therapy for bisphosphonaterelated osteonecrosis of the jaw in a rat model", Acta Biomater, 42, pp.400~410 (2016)[DOI]
  4. Colella G, "American Association of Oral and Maxillofacial Surgeons position paper: bisphosphonate-related osteonecrosis of the jaws-2009 update: the need to refine the BRONJ definition", J Oral Maxillofac Surg, 67, pp.2698~2699 (2009)[DOI]
  5. Kos M, "Bisphosphonaterelated osteonecrosis of the jaws: a review of 34 cases and evaluation of risk", J Craniomaxillofac Surg, 38, pp.255~259 (2010)[DOI]
  6. Otto S, "Bisphosphonate-related osteonecrosis of the jaws-characteristics, risk factors, clinical features, localization and impact on oncological treatment", J Craniomaxillofac Surg, 40, pp.303~309 (2012)[DOI]
  7. Pichardo SE, "Bisphosphonate related osteonecrosis of the jaws: spontaneous or dental origin?", Oral Surg Oral Med Oral Pathol Oral Radiol, 116, pp.287~292 (2013)[DOI]
  8. Vaszilko M, "Potential significance of antiestrogen therapy in the development of bisphosphonate related osteonecrosis of the jaw", J Craniomaxillofac Surg, 42, pp.1932~1936 (2014)[DOI]
  9. Voss PJ, "Surgical treatment of bisphosphonate-associated osteonecrosis of the jaw: technical report and follow up of 21 patients", J Craniomaxillofac Surg, 40, pp.719~725 (2012)[DOI]
  10. "Osteonecrosis"[URL]
  11. "Osteonecrosis of the jaw"[URL]
  12. Keskinruzgar A, "Histopathological effects of teriparatide in medication-related osteonecrosis of the jaw : an animal study", J Oral Maxillofac Surg, 74, pp.68~78 (2016)[DOI]
  13. Dayisoylu EH, "The effects of adjunctive parathyroid hormone injection on bisphosphonate-related osteonecrosis of the jaws: an animal study", Int J Oral Maxillofac Surg, 42, pp.1475~1480 (2013)[DOI]
  14. Zandi M, "Short-term perioperative teriparatide therapy for the prevention of medication-related osteonecrosis of the jaw : a randomized, controlled preclinical study in rats", J Craniomaxillofac Surg, 45, pp.275~280 (2017)[DOI]
  15. Del Fabbro M, "Autologous platelet concentrates for bisphosphonate-related osteonecrosis of the jaw treatment and prevention. A systematic review of the literature", Eur J Cancer, 51, pp.62~74 (2015)[DOI]
  16. Ogata K, "Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model", Bone, 74, pp.95~105 (2015)[DOI]
  17. López-Jornet P, "Perioperative antibiotic regimen in rats treated with pamidronate plus dexamethasone and subjected to dental extraction: a study of the changes in the jaws", J Oral Maxillofac Surg, 69, pp.2488~2493 (2011)[DOI]
  18. Yanık S, "Histopathological features of bisphosphonates related osteonecrosis of the jaw in rats with and without vitamin d supplementation", Arch Oral Biol, 65, pp.59~65 (2016)[DOI]
  19. Koneski F, "In vivo effects of geranylgeraniol on the development of bisphosphonate-related osteonecrosis of the jaws", J Craniomaxillofac Surg, 46, pp.230~236 (2018)[DOI]
  20. Najeeb S, "Therapeutic potential of melatonin in oral medicine and periodontology", Kaohsiung J Med Sci, 32, pp.391~396 (2016)[DOI]
  21. Carpentieri AR, "Melatonin and periodontal tissues : molecular and clinical perspectives", Pharmacol Res, 125(Pt B), pp.224~231 (2017)[DOI]
  22. Gómez-Florit M, "Anti-fibrotic and antiinflammatory properties of melatonin on human gingival fibroblasts in vitro", Biochem Pharmacol, 86, pp.1784~1790 (2013)[DOI]
  23. Ramírez-Fernández MP, "Melatonin promotes angiogenesis during repair of bone defects : a radiological and histomorphometric study in rabbit tibiae", Clin Oral Investig, 17, pp.147~158 (2013)[DOI]
  24. Soybir G, "The effects of melatonin on angiogenesis and wound healing", Surg Today, 33, pp.896~901 (2003)[DOI]
  25. Nakamura E, "Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A(MTNR1A)in oral squamous-cell carcinoma", Cancer Sci, 99, pp.1390~1400 (2008)[DOI]
  26. Cutando A, "Local application of melatonin into alveolar sockets of beagle dogs reduces tooth removal-induced oxidative stress", J Periodontol, 78, pp.576~583 (2007)[DOI]
  27. Barba-Recreo P, "Zoledronic acid - related osteonecrosis of the jaws. Experimental model with dental extractions in rats", J Craniomaxillofac Surg, 42, pp.744~750 (2014)[DOI]
  28. Zandi M, "Introducing a protocol to create bisphosphonate-related osteonecrosis of the jaw in rat animal model", J Craniomaxillofac Surg, 44, pp.271~278 (2016)[DOI]
  29. Wayama MT, "Diminished progression of periapical lesions with zoledronic acid in ovariectomized rats", J Endod, 41, pp.2002~2007 (2015)[DOI]
  30. Jabbour Z, "Bacterial profile and bone healing in rats receiving cancer therapeutic doses of bisphosphonates and corticosteroids : a pilot study", Int J Oral Maxillofac Surg, 45, pp.1162~1169 (2016)[DOI]
  31. Cutando A, "A new perspective in oral health : potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR", ROR in the oral cavity, 2011, pp.56, 944~950
  32. Kara A, "Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats", Free Radic Biol Med, 55, pp.21~26 (2013)[DOI]
  33. Reiter RJ, "Melatonin in the oral cavity : physiological and pathological implications", J Periodontal Res, 50, pp.9~17 (2015)[DOI]
  34. Arabacı T, "Therapeutic effects of melatonin on alveolar bone resorption after experimental periodontitis in rats: a biochemical and immunohistochemical study", J Periodontol, 86, pp.874~881 (2015)[DOI]
  35. Ruggierro SL, "Oral and maxillofacial surgery", pp.507~522 (2018), Elsevier

관련 논문AI추천

Enhancement of peri-implant bone formation via parathyroid hormone administration in a rat model at risk for medication-related osteonecrosis of the jaw박수현, 박지영, 표성운, 허현아대한치주과학회 · Journal of Periodontal & Implant Science2020 · 제50권 제2호The effects of zoledronic acid on the progression of experimental periodontitis in rats: histological and microtomographic analysesDanyel Elias da Cruz Perez, Diego Moura Soares, Flávia Maria de Moraes Ramos-Perez, Liriane Baratella Evêncio, Maria Luiza dos Anjos Pontual, Priscylla Gonçalves Correia Leite de Marcelos, Samuel Silva de Araújo대한치주과학회 · Journal of Periodontal & Implant Science2021 · 제51권 제4호Altered VEGF Regulation in Ovariectomized Rat Alveolar Bone Sockets by BisphosphonateDong-Wook Yang, Geum-Dong Han, Sun-Hun Kim대한구강해부학회 · 대한구강해부학회지2018 · 제39권 제1호The effect of bisphosphonate discontinuation on the incidence of postoperative medication-related osteonecrosis of the jaw after tooth extraction강상훈, 김문기, 박세진대한구강악안면외과학회 · 대한구강악안면외과학회지2020 · 제46권 제1호Mesenchymal stem cells in the treatment of osteonecrosis of the jawAntonio Fabrizio Nifosì, Gianfilippo Nifosì, Lorenzo Nifosì대한구강악안면외과학회 · 대한구강악안면외과학회지2021 · 제47권 제2호Effect of alendronate on bone remodeling around implant in the rat박란, 김지환, 문홍석, 박영범, 정한성, 최현민대한치과보철학회 · The Journal of Advanced of Prosthodontics2013 · 제5권 제4호

이 간행물의 다른 논문 (11건)