심장 수술 후 발생한 혈전증을 동반한 헤파린 기인성 혈소판 감소증의 치료-증례 보고-
The Management of Heparin-induced Thrombocytopenia with Thrombosis after Open Heart Surgery-A Case Report -
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Heparin-induced thrombocytopenia (HIT) is a prothrombotic, immune-mediated adverse reaction to heparin therapy. It is caused by antibodies binding to a complex of heparin and platelet factor 4, and this leads to platelet activation,excessive thrombin generation and often thrombosis. HIT with thrombosis (HITT) can lead to limb amputation,stroke, myocardial infarction and death. We report here on a case of a HITT patient who was successfully managed with argatroban therapy. Further knowledge is need about the ideal medical management for HITT.
Abstract
Heparin-induced thrombocytopenia (HIT) is a prothrombotic, immune-mediated adverse reaction to heparin therapy. It is caused by antibodies binding to a complex of heparin and platelet factor 4, and this leads to platelet activation,excessive thrombin generation and often thrombosis. HIT with thrombosis (HITT) can lead to limb amputation,stroke, myocardial infarction and death. We report here on a case of a HITT patient who was successfully managed with argatroban therapy. Further knowledge is need about the ideal medical management for HITT.
참고문헌 (7)
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