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상악동염 병소 부위에서 세균의 분리 동정 및 항생제 감수성에 대한 연구

Antibiotic susceptibility of bacteria isolated from maxillary sinusitis lesion

김민정|김영종|김수관|김학균|국중기|최동국|김미광|최영옥|박순낭
대한구강악안면외과학회 (Korean Association Of Oral And Maxillofacial Surgeons)|2006.10|대한구강악안면외과학회지 (Journal of the Korean Association of Oral and Maxillofacial Surgeons)|제32권 제5호|pp. 436-

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참고문헌

주제분류치의학

초록

Abstract

The purpose of this study was to isolate and identify the bacteria in chronic maxillary sinusitis (CMS) lesions from 3 patients and to determine the antimicrobial susceptibility of them against 10 antibiotics. One of them was odontogenic origin and the others were non-odontogenic origin. Pus samples were collected by needle aspiration from the lesions and examined by culture method. Bacterial culture was performed in three culture systems (anaerobic, CO2, and aerobic incubator). Identification of the bacteria was performed by 16S rRNA gene (16S rDNA) nucleotide sequencing method. To test the sensitivity of the bacteria isolated from the maxillary sinusitis lesions against seven antibiotics, penicillin G, amoxicillin, tetracycline, ciprofloxacin, cefuroxime, erythromycin, clindamycin, and vancomycin, minimum inhibitory concentration (MIC) was performed using broth dilution assay. Our data showed that enterobacteria such as Enterobacter aerogenes (30%), Klebsiella pneumoniae (25%), and Serratia marcescens (15%) were predominately isolated from the lesion of non-odontogenic CMS of senile patient (70 year old). Streptococcus spp. (40.3%), Actinomyces spp. (27.4%), P. nigrescens, M. micros, and P. anaerobius strains were isolated in the lesion of odontogenic CMS. In the lesion of non-odontogenic CMS, Streptococcus spp. (68.4%), Rothia spp. (13.2%), and Actinomyces sp. (10.5%) were isolated. The susceptibility pattern of 10 antibiotics was determined according to the host of the bacteria strains ratter than the kinds of bacterial species. Even though the number of CMS was limited as three, these results indicate that antibiotic susceptibility test must be accompanied with treatment of CMS. The combined treatment of two or more antibiotics is better than single antibiotic treatment in the presence of multidrug-resistant bacteria in the CMS lesions.

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상악동 술후점액낭종의 미생물 동정이봉재, 이시형, 임현우, 장용주, 정유삼, 한광우대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2004 · 제47권 제11호구강악안면 감염 질환에서 배양된 세균의 양상과 항생제 감수성국민석, 김선국, 유선열, 한창훈대한구강악안면외과학회 · 대한구강악안면외과학회지2005 · 제31권 제4호악골골수염에서 분리된 연쇄상구균의 수종 항생제에 대한 감수성 조사국중기, 김미광, 김수관, 임석균대한구강악안면외과학회 · 대한구강악안면외과학회지2004 · 제30권 제3호상악동에서 발생한 방선균증 1예윤기중, 이재훈, 전경호대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2007 · 제50권 제1호구강악안면 감염 환자에서 흡인법을 이용하여 조사한 세균감염 양상김일규, 박승훈, 박종원, 백민규, 장금수, 조정현, 조현영대한구강악안면외과학회 · 대한구강악안면외과학회지2008 · 제34권 제5호급성 비부비동염이 유발된 생쥐에서 항균제의 국소투여 효과남영진, 류남희, 박순형, 송인혁, 안병훈, 여창기, 조유미대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2006 · 제49권 제11호

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