Epithelial-mesenchymal transition in osteogenic sarcoma of the neck following oral squamous cell carcinoma
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Postirradiation extraosseous osteogenic sarcomas are uncommon in the head and neck, despite the extensive use of high-dose radiation. It has been described as de novo radiation-induced neoplasm. We present a 73-year-old male who had been treated by radiotherapy for gingival cancer 7 years earlier and later developed extraosseous osteogenic sarcomas (EOSs) of the neck. Microscopically, the neck mass was composed with mesenchymal malignant cells with cartilaginous and osteogenic differentiation. Immunohistochemical stain demonstrated strong positivity of tumor cells for Snail,the one of major epithelial-mesenchymal transition (EMT) inducer. The E-cadherin expression was scarce, showing inverse relationship to Snail expression. Compared with previous squamous cell carcinoma (SCC) of the gingiva, the present EOS sample revealed the remained epithelial cells on cytokeratin immunohistochemistry, suggesting the tumor arise from the cells of epithelial origin. We have also reviewed the previous 6 cases of head and neck EOSs carefully. The clinicopathologic features of the unusual lesion suggest that it is an incomplete EMT of precedent epithelial malignancy rather than de novo pathology.
Abstract
Postirradiation extraosseous osteogenic sarcomas are uncommon in the head and neck, despite the extensive use of high-dose radiation. It has been described as de novo radiation-induced neoplasm. We present a 73-year-old male who had been treated by radiotherapy for gingival cancer 7 years earlier and later developed extraosseous osteogenic sarcomas (EOSs) of the neck. Microscopically, the neck mass was composed with mesenchymal malignant cells with cartilaginous and osteogenic differentiation. Immunohistochemical stain demonstrated strong positivity of tumor cells for Snail,the one of major epithelial-mesenchymal transition (EMT) inducer. The E-cadherin expression was scarce, showing inverse relationship to Snail expression. Compared with previous squamous cell carcinoma (SCC) of the gingiva, the present EOS sample revealed the remained epithelial cells on cytokeratin immunohistochemistry, suggesting the tumor arise from the cells of epithelial origin. We have also reviewed the previous 6 cases of head and neck EOSs carefully. The clinicopathologic features of the unusual lesion suggest that it is an incomplete EMT of precedent epithelial malignancy rather than de novo pathology.
참고문헌 (25)
- Lin SY, "Extraosseous osteogenic sarcoma", J Chin Med Assoc, 68, pp.542~545 (2005)
- Rao U, "Extraosseous osteogenic sarcoma: clinicopathological study of eight cases and review of literature", Cancer, 41, pp.1488~1496 (1978)
- Sordillo PP, "Extraosseous osteogenic sarcoma. A review of 48 patients", Cancer, 51, pp.727~734 (1983)
- Manning JT, "Extraosseous osteogenic sarcoma of the parotid gland", J Laryngol Otol, 100, pp.239~242 (1986)
- Das Gupta TK, "Extraosseous osteogenic sarcoma", Ann Surg, 168, pp.1011~1022 (1968)
- Jussawalla DJ, "Primary osteogenic sarcoma arising in extra-skeletal soft tissues of the neck", Br J Surg, 51, pp.504~505 (1964)
- Parsons WH, "Extraskeletal osteogenic sarcoma : report of a case of osteogenic sarcoma of the lip", Ann Surg, 119, pp.595~601 (1944)
- Shanoff LB, "Myositis ossificans: evolution to osteogenic sarcoma. Report of a histologically verified case", Am J Surg, 113, pp.537~541 (1967)
- Yook JI, "Wnt-dependent regulation of the E-cadherin repressor snail", J Biol Chem, 280, pp.11740~11748 (2005)
- Yook JI, "A Wnt- Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells", Nat Cell Biol, 8, pp.1398~1406 (2006)
- Allan CJ, "Osteogenic sarcoma of the somatic soft tissues. Clinicopathologic study of 26 cases and review of literature", Cancer, 27, pp.1121~1133 (1971)
- Kauffman SL, "Extraskeletal osteogenic sarcomas and chondrosarcomas in children", Cancer, 16, pp.432~439 (1963)
- Wurlitzer F, "Extraosseous osteogenic sarcoma", Arch Surg, 105, pp.691~695 (1972)
- Kalra S, "Radiation-induced sarcomas of bone: factors that affect outcome", J Bone Joint Surg Br, 89, pp.808~813 (2007)
- Tan A, "Post-radiation sarcoma of the neck treated with re-irradiation followed by wide excision", World J Surg Oncol, 4, pp.69~ (2006)
- Oda H, "Dynamic behavior of the cadherin- based cell-cell adhesion system during Drosophila gastrulation", Dev Biol, 203, pp.435~450 (1998)
- Peinado H, "Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?", Nat Rev Cancer, 7, pp.415~428 (2007)
- Thiery JP, "Epithelial-mesenchymal transitions in tumour progression", Nat Rev Cancer, 2, pp.442~454 (2002)
- Becker KF, "Analysis of the E-cadherin repressor Snail in primary human cancers", Cells Tissues Organs, 185, pp.204~212 (2007)
- Francｌ′C, "Expression of Snail protein in tumor-stroma interface", Oncogene, 25, pp.5134~5144 (2006)
- Fine G, "Osteogenic sarcoma of the extraskeletal soft tissues", Cancer, 9, pp.1027~1043 (1956)
- Brabletz T, "Invasion and metastasis in colorectal cancer: epithelial- mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin", Cells Tissues Organs, 179, pp.56~65 (2005)
- Jeschke U, "Expression of E-cadherin in human ductal breast cancer carcinoma in situ, invasive carcinomas, their lymph node metastases, their distant metastases, carcinomas with recurrence and in recurrence", Anticancer Res, 27, pp.1969~1974 (2007)
- Liu J, "N. Re-expression of the cadherin-catenin complex in lymph nodes with metastasis in advanced gastric cancer: the relationship with patient survival", J Exp Clin Cancer Res, 21, pp.65~71 (2002)
- Park D, "Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gammacatenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis", APMIS, 115, pp.52~65 (2007)