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Moderate to Severe Left Ventricular Ejection Fraction Related to Short-term Mortality of Patients with Post-cardiac Arrest Syndrome after Out-of-Hospital Cardiac Arrest

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Background: The aim of this study was to investigate the relationships between left ventricular ejection fraction (LVEF) and mortality and neurologic outcomes with post-cardiac arrest syndrome (PCAS) after out-of-hospital cardiac arrest (OHCA). Methods: Patients with PCAS after OHCA admitted to the intensive care unit between January 2014 and December 2015 were analyzed retrospectively. Results: A total of 104 patients were enrolled in this study. The mean age was 54.4 ± 15.3 years, and 75 of the patients were male (72.1%). Arrest with a cardiac origin was found in 55 (52.9%). LVEF < 45%, 45-55%, and > 55% was measured in 39 (37.5%), 18 (17.3%), and 47 (45.2%) of patients, respectively. In multivariate analysis, severe LV dysfunction (LVEF < 45%) was significantly related to 7-day mortality (odds ratio 3.02, 95% Confidence Interval 1.01-9.0, p-value 0.047). Conclusions: In this study, moderate to severe LVEF within 48 hours after return of spontaneous circulation was significantly related to 7-day short-term mortality in patients with PCAS after OHCA. Clinicians should actively treat myocardial dysfunction, and further studies are needed.

Abstract

Background: The aim of this study was to investigate the relationships between left ventricular ejection fraction (LVEF) and mortality and neurologic outcomes with post-cardiac arrest syndrome (PCAS) after out-of-hospital cardiac arrest (OHCA). Methods: Patients with PCAS after OHCA admitted to the intensive care unit between January 2014 and December 2015 were analyzed retrospectively. Results: A total of 104 patients were enrolled in this study. The mean age was 54.4 ± 15.3 years, and 75 of the patients were male (72.1%). Arrest with a cardiac origin was found in 55 (52.9%). LVEF < 45%, 45-55%, and > 55% was measured in 39 (37.5%), 18 (17.3%), and 47 (45.2%) of patients, respectively. In multivariate analysis, severe LV dysfunction (LVEF < 45%) was significantly related to 7-day mortality (odds ratio 3.02, 95% Confidence Interval 1.01-9.0, p-value 0.047). Conclusions: In this study, moderate to severe LVEF within 48 hours after return of spontaneous circulation was significantly related to 7-day short-term mortality in patients with PCAS after OHCA. Clinicians should actively treat myocardial dysfunction, and further studies are needed.

참고문헌 (27)

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관련 논문AI추천

Erratum: Moderate to Severe Left Ventricular Ejection Fraction Related to Short-term Mortality of Patients with Post-cardiac Arrest Syndrome after Out-of-Hospital Cardiac Arrest이근, 김진주, 민경진, 양혁준, 우재혁, 임용수, 황인철대한중환자의학회 · Acute and Critical Care2017 · 제32권 제1호병원외 심정지 후 집중치료실에 입원한 환자의 예후: 심장성과 비심장성 심정지 비교강환석, 김준식, 김지혜, 백진휘, 이훈재, 조재화, 한승백대한중환자의학회 · Acute and Critical Care2010 · 제25권 제4호Acute Physiologic and Chronic Health Examination II and Sequential Organ Failure Assessment Scores for Predicting Outcomes of Out-of-Hospital Cardiac Arrest Patients Treated with Therapeutic Hypothermia김성준, 김진주, 박원빈, 양혁준, 임용수, 조진성대한중환자의학회 · Acute and Critical Care2014 · 제29권 제4호APACHE II Score Immediately after Cardiac Arrest as a Predictor of Good Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Receiving Targeted Temperature Management김상일, 김원영, 서동우, 손창환, 이윤선, 이재호, 임경수, Seung Mok Ryoo, You-Jin Lee, Youn-Jung Kim대한중환자의학회 · Acute and Critical Care2018 · 제33권 제2호병원 전 심정지 환자를 대상으로 한 제세동 횟수와 생존율 및 신경학적 예후와의 연관성김우진, 김진주, 양혁준, 장재호, 현성열대한중환자의학회 · Acute and Critical Care2012 · 제27권 제4호Management of post-cardiac arrest syndrome강영준대한중환자의학회 · Acute and Critical Care2019 · 제34권 제3호

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