Clinical features and outcomes of critically ill patients with Elizabethkingia meningoseptica: an emerging pathogen
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Elizabethkingia meningoseptica, formerly known as Chryseobacterium meningosepticum, is a non-motile, non-fastidious, catalase and oxidase-positive, aerobic, glucosenon-fermentative, Gram-negative bacillus that was first defined by Elizabeth O. King in 1959. It has emerged as an opportunistic pathogen that has infected patients in extreme age groups and immunocompromised individuals, especially in intensive care settings. There has been an increased interest in this pathogen due to its increasing occurrence around the world, ubiquitous nature, and inherent capacity for antimicrobial resistance. Methods: We describe an observational study at a tertiary care center in Karachi, Pakistan, based on patients admitted between January 2013 and December 2018, with E. meningoseptica infections. All patients were confirmed to have a positive clinical culture specimen for E. meningoseptica along with symptoms and signs consistent with infection. Data were collected on a structured proforma from the Hospital Information Management Systems. Results: Sixteen patients with E. meningoseptica that met the criteria for infection were identified, 13 of whom required admission. Eight patients had bacteremia in addition to confirmed E. meningoseptica infection. Two of the isolates were multi-drug resistant and only sensitive to minocycline. Nine out of 13 patients that were admitted required intubation and mechanical ventilation. The median length of hospital stay was 13 days, and five out of the 13 patients died during the hospital stay. Conclusions: This is the largest case series to date reporting E. meningoseptica infections and highlights the importance of this organism as an emerging nosocomial pathogen.
Abstract
Background: Elizabethkingia meningoseptica, formerly known as Chryseobacterium meningosepticum, is a non-motile, non-fastidious, catalase and oxidase-positive, aerobic, glucosenon-fermentative, Gram-negative bacillus that was first defined by Elizabeth O. King in 1959. It has emerged as an opportunistic pathogen that has infected patients in extreme age groups and immunocompromised individuals, especially in intensive care settings. There has been an increased interest in this pathogen due to its increasing occurrence around the world, ubiquitous nature, and inherent capacity for antimicrobial resistance. Methods: We describe an observational study at a tertiary care center in Karachi, Pakistan, based on patients admitted between January 2013 and December 2018, with E. meningoseptica infections. All patients were confirmed to have a positive clinical culture specimen for E. meningoseptica along with symptoms and signs consistent with infection. Data were collected on a structured proforma from the Hospital Information Management Systems. Results: Sixteen patients with E. meningoseptica that met the criteria for infection were identified, 13 of whom required admission. Eight patients had bacteremia in addition to confirmed E. meningoseptica infection. Two of the isolates were multi-drug resistant and only sensitive to minocycline. Nine out of 13 patients that were admitted required intubation and mechanical ventilation. The median length of hospital stay was 13 days, and five out of the 13 patients died during the hospital stay. Conclusions: This is the largest case series to date reporting E. meningoseptica infections and highlights the importance of this organism as an emerging nosocomial pathogen.
참고문헌 (17)
- Kim KK, "Transfer of Chryseobacterium meningosepticum and Chryseobacterium miricola to Elizabethkingia gen. nov. as Elizabethkingia meningoseptica comb. nov. and Elizabethkingia miricola comb. nov", Int J Syst Evol Microbiol, 55(Pt 3), pp.1287~1293 (2005)
- Teo J, "Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis", Genome Biol Evol, 6, pp.1158~1165 (2014)
- Jean SS, "Elizabethkingia meningoseptica : an important emerging pathogen causing healthcare-associated infections", J Hosp Infect, 86, pp.244~249 (2014)
- Mukerji R, "Chryseobacterium indologenes: an emerging infection in the USA", BMJ Case Rep, 2016 (2016)
- Tuon FF, "Chryseobacterium meningosepticum as a cause of cellulitis and sepsis in an immunocompetent patient", J Med Microbiol, 56(Pt 8), pp.1116~1117 (2007)
- (2016)[URL]
- Hsu MS, "Clinical features, antimicrobial susceptibilities, and outcomes of Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)bacteremia at a medical center in Taiwan, 1999-2006", Eur J Clin Microbiol Infect Dis, 30, pp.1271~1278 (2011)
- Loch TP, "Emerging flavobacterial infections in fish : a review", J Adv Res, 6, pp.283~300 (2015)
- (2021)[URL]
- Magiorakos AP, "Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance", Clin Microbiol Infect, 18, pp.268~281 (2012)
- Khan ID, "Multiresistant Elizabethkingia meningoseptica infections in tertiary care", Med J Armed Forces India, 71, pp.282~286 (2015)
- Arbune M, "Emerging infection with Elizabethkingia meningoseptica in neonate : a case report", J Crit Care Med(Targu Mures), 4, pp.96~100 (2018)
- Celik K, "Colonization and infection with a rare microorganism in a neonatal intensive care unit: three preterm infants with Elizabethkingia meningoseptica", Arch Argent Pediatr, 117, pp.e631~e634 (2019)
- Hamza WS, "Epidemiological analysis of Elizabethkingia meningoseptica infection cluster among mechanically ventilated pediatric intensive care patients", Int J Community Med Public Health, 5, pp.3212~3219 (2018)
- Sahu MK, "Elizabethkingia meningoseptica : an emerging nosocomial pathogen causing septicemia in critically ill patients", Indian J Crit Care Med, 23, pp.104~105 (2019)
- Raghavan S, "Elizabethkingia meningoseptica:Emerging multidrug resistance in a nosocomial pathogen", BMJ Case Rep, 2017 (2017)
- Dziuban EJ, "Elizabethkingia in children : a comprehensive review of symptomatic cases reported from 1944 to 2017", Clin Infect Dis, 67, pp.144~149 (2018)