Evaluation of the predisposing factors and involved outcome of surgical treatment in bisphosphonate-related osteonecrosis of the jaw cases including bone biopsies
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Objectives: This study examined the statistical relevance of whether the systemic predisposing factors affect the prognosis of surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ). All cases had undergone bone biopsies to determine the characteristics of the mechanisms of BRONJ by optical microscopy.Materials and Methods: The data included 54 BRONJ cases who underwent surgery and in whom bone biopsies were performed. The results of surgery were evaluated and the results were classified into 3 categories: normal recovery, delayed recovery, and recurrence after surgery. The medical history, such as diabetes mellitus, medication of steroids, malignancies on other sites was investigated for an evaluation of the systemic predispos-ing factors in relation to the prognosis. The three factors involved with the medication of bisphosphonate (BP) were the medication route, medication period, and drug holiday of BP before surgery. The serum C-terminal cross-linking telopeptide (CTX) value and presence of microorganism colony in bone biopsy specimens were also checked. Statistical analysis was then carried out to determine the relationship between these factors and the results of surgery.Results: The group of patients suffering from diabetes and on steroids tended to show poorer results after surgery. Parenteral medication of BP made the patients have a poorer prognosis after surgery than oral medication. In contrast, the medication period and drug holiday of BP before surgery did not have significance with the results of surgery nor did the serum CTX value and presence of microorganism colony. Necrotic bone specimens in this study typically showed disappearing new bone formation around the osteocytic lacunae and destroyed Howship’s lacunae.Conclusion: Although many variables exist, this study could in part, predict the prognosis of surgical treatment of BRONJ by taking the patient’s medical history.
Abstract
Objectives: This study examined the statistical relevance of whether the systemic predisposing factors affect the prognosis of surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ). All cases had undergone bone biopsies to determine the characteristics of the mechanisms of BRONJ by optical microscopy.Materials and Methods: The data included 54 BRONJ cases who underwent surgery and in whom bone biopsies were performed. The results of surgery were evaluated and the results were classified into 3 categories: normal recovery, delayed recovery, and recurrence after surgery. The medical history, such as diabetes mellitus, medication of steroids, malignancies on other sites was investigated for an evaluation of the systemic predispos-ing factors in relation to the prognosis. The three factors involved with the medication of bisphosphonate (BP) were the medication route, medication period, and drug holiday of BP before surgery. The serum C-terminal cross-linking telopeptide (CTX) value and presence of microorganism colony in bone biopsy specimens were also checked. Statistical analysis was then carried out to determine the relationship between these factors and the results of surgery.Results: The group of patients suffering from diabetes and on steroids tended to show poorer results after surgery. Parenteral medication of BP made the patients have a poorer prognosis after surgery than oral medication. In contrast, the medication period and drug holiday of BP before surgery did not have significance with the results of surgery nor did the serum CTX value and presence of microorganism colony. Necrotic bone specimens in this study typically showed disappearing new bone formation around the osteocytic lacunae and destroyed Howship’s lacunae.Conclusion: Although many variables exist, this study could in part, predict the prognosis of surgical treatment of BRONJ by taking the patient’s medical history.
참고문헌 (45)
- McClung MR, "Bisphosphonates", Endocrinol Metab Clin North Am, 32, pp.253~271 (2003)
- Stanton DC, "Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases", J Oral Maxillofac Surg, 67, pp.943~950 (2009)
- Marx RE, "Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic", J Oral Maxillofac Surg, 61, pp.1115~1117 (2003)
- Ruggiero SL, "Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases", J Oral Maxillofac Surg, 62, pp.527~534 (2004)
- Hinson AM, "Is bisphosphonate-related osteonecrosis of the jaw an infection? A histological and microbiological ten-year summary", Int J Dent (2014)[DOI]
- Ohe JY, "Bisphosphonates modulate the expression of OPG and M-CSF in hMSC-derived osteoblasts", Clin Oral Investig, 16, pp.1153~1159 (2012)
- Kim RH, "Bisphosphonates induce senescence in normal human oral keratinocytes", J Dent Res, 90, pp.810~816 (2011)
- Kos M, "Clinical comparison of patients with osteonecrosis of the jaws, with and without a history of bisphosphonates administration", Int J Oral Maxillofac Surg, 39, pp.1097~1102 (2010)
- Lee SH, "Risk of osteonecrosis in patients taking bisphosphonates for prevention of osteoalsoa systematic review and meta-analysis", Osteoporos Int, 25, pp.1131~1139 (2014)
- Khamaisi M, "Possible association between diabetes and bisphosphonaterelated jaw osteonecrosis", J Clin Endocrinol Metab, 92, pp.1172~1175 (2007)
- Sung EC, "Osteonecrosis of the maxilla as a complication to chemotherapy: a case report", Spec Care Dentist, 22, pp.142~146 (2002)
- Tarassoff P, "Avascular necrosis of the jaws: risk factors in metastatic cancer patients", J Oral Maxillofac Surg, 61, pp.1238~1239 (2003)
- Migliorati CA, "Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy", Cancer, 104, pp.83~93 (2005)
- Hewitt C, "Bisphosphonate-related osteonecrosis of the jaws: a comprehensive review", J Oral Pathol Med, 36, pp.319~328 (2007)
- Leite AF, "Bisphosphonate-associated osteonecrosis of the jaws. Report of a case and literature review", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 102, pp.14~21 (2006)
- Marx RE, "Oral bisphosphonate-induced osteonecrosis:risk factors, prediction of risk using serum CTX testing, prevention, and treatment", J Oral Maxillofac Surg, 65, pp.2397~2410 (2007)
- Freiberger JJ, "Hyperbaric oxygen treatment and bisphosphonateinduced osteonecrosis of the jaw: a case series", J Oral Maxillofac Surg, 65, pp.1321~1327 (2007)
- Vescovi P, "Bisphosphonateassociated osteonecrosis (BON) of the jaws: a possible treatment?", J Oral Maxillofac Surg, 64, pp.1460~1462 (2006)
- Lopes RN, "Surgical therapy for bisphosphonate-related osteonecrosis of the jaw:six-year experience of a single institution", J Oral Maxillofac Surg, 73, pp.1288~1295 (2015)
- Stockmann P, "The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months", Clin Oral Investig, 18, pp.1299~1304 (2014)
- Carlson ER, "The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws", J Oral Maxillofac Surg, 67(5 Suppl), pp.85~95 (2009)
- Reich W, "Surgical treatment of bisphosphonate-associated osteonecrosis:Prognostic score and long-term results", J Craniomaxillofac Surg, 43, pp.1809~1822 (2015)
- 김경욱, "비스포스포네이트 관련 악골괴사의 진단 및 치료에 대한 임상적 연구", 대한구강악안면외과학회지, 37(1), pp.54~61 (2011), 대한구강악안면외과학회
- Lehenkari PP, "Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP", ATP translocase by a nonhydrolyzable, adenine-containing metabolite, 2002, pp.61, 1255~1262
- Molcho S, "Diabetes microvascular disease and the risk for bisphosphonate-related osteonecrosis of the jaw: a single center study", J Clin Endocrinol Metab, 98, pp.E1807~1812 (2013)
- Watters AL, "Intravenous bisphosphonate-related osteonecrosis of the jaw: long-term follow-up of 109 patients", Oral Surg Oral Med Oral Pathol Oral Radiol, 115, pp.192~200 (2013)
- Favus MJ, "Diabetes and the risk of osteonecrosis of the jaw", J Clin Endocrinol Metab, 92, pp.817~818 (2007)
- Ichiseki T, "Oxidative stress by glutathione depletion induces osteonecrosis in rats", Rheumatology (Oxford), 45, pp.287~290 (2006)
- Ortega C, "Osteonecrosis of the jaw in prostate cancer patients with bone metastases treated with zoledronate: a retrospective analysis", Acta Oncol, 46, pp.664~668 (2007)
- Vieillard MH, "Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy", Joint Bone Spine, 75, pp.34~40 (2008)
- Kos M, "Bisphosphonate-related osteonecrosis of the jaws: a review of 34 cases and evaluation of risk", J Craniomaxillofac Surg, 38, pp.255~259 (2010)
- Brown JE, "Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors", J Natl Cancer Inst, 97, pp.59~69 (2005)
- Garnero P, "Noninvasive techniques for assessing skeletal changes in inflammatory arthritis: bone biomarkers", Curr Opin Rheumatol, 16, pp.428~434 (2004)
- Fleisher KE, "Predicting risk for bisphosphonate-related osteonecrosis of the jaws: CTX versus radiographic markers", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 110, pp.509~516 (2010)
- Kunchur R, "Clinical investigation of C-terminal cross-linking telopeptide test in prevention and management of bisphosphonate-associated osteonecrosis of the jaws", J Oral Maxillofac Surg, 67, pp.1167~1173 (2009)
- American Society for Bone and Mineral Research Task Force on Osteonecrosis of the Jaw, "Oral bisphosphonate-induced osteonecrosis:risk factors, prediction of risk using serum CTX testing, prevention, and treatment", J Oral Maxillofac Surg, 66, pp.1320~1321 (2008)
- Berger CE, "Spontaneous osteonecrosis of the knee: biochemical markers of bone turnover and pathohistology", Osteoarthritis Cartilage, 13, pp.716~721 (2005)
- Ganguli A, "Bacterial adhesion to bisphosphonate coated hydroxyapatite", J Mater Sci Mater Med, 16, pp.283~287 (2005)
- Kos M, "Pamidronate enhances bacterial adhesion to bone hydroxyapatite. Another puzzle in the pathology of bisphosphonaterelated osteonecrosis of the jaw?", J Oral Maxillofac Surg, 71, pp.1010~1016 (2013)
- Anavi-Lev K, "Bisphosphonate related osteonecrosis of the jaws: clinico-pathological investigation and histomorphometric analysis", Oral Surg Oral Med Oral Pathol Oral Radiol, 115, pp.660~666 (2013)
- Hansen T, "Actinomycosis of the jaws--histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis", Virchows Arch, 451, pp.1009~1017 (2007)
- Naik NH, "Bisphosphonate-related osteonecrosis of the jaw: the role of actinomyces", Clin Infect Dis, 49, pp.1729~1732 (2009)
- Kumar SK, "The role of microbial biofilms in osteonecrosis of the jaw associated with bisphosphonate therapy", Curr Osteoporos Rep, 8, pp.40~48 (2010)
- Sedghizadeh PP, "Metagenomic investigation of microbes and viruses in patients with jaw osteonecrosis associated with bisphosphonate therapy", Oral Surg Oral Med Oral Pathol Oral Raporosisdiol, 114, pp.764~770 (2012)
- Marx RE, "Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease", Int J Oral Maxillofac Surg, 41, pp.283~289 (2012)
