Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosisIntraoral diagnosis
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Individuals with human immunodeficiency virus (HIV) infection present with unique intraoral manifestations of various neoplasms. Intraoral HIV-associated Burkitt’s lymphoma is a rare presentation, especially in patients of Indian origin and may present as an initial sign of HIV. The objective of this paper is to report a rare case of Burkitt’s lymphoma in an HIV-positive Indian patient along with a special emphasis on differential diagnosis. A 30-year-old Indian female presented with a solitary, well-defined, exophytic mass extending anteroposteriorly and buccolingually from the 35th to 38th regions with no evidence of intraosseous extension. An incisional biopsy was performed, and histopathology showed sheets of neoplastic lymphoid cells with numerous tingible body macrophages with clear cytoplasm, presenting a starry sky appearance, suggesting a diagnosis of BL. The tumor cells were positive for CD10, CD20, c-myc, and Epstein–Barr virus, with a nearly 100% Ki-67 proliferative index. The patient tested positive for HIV. This report indicates the importance of immunohistochemical analysis to differentiate Burkitt’s lymphoma from other similar lesions like diffuse large B-cell lymphoma. Thorough knowledge of the clinical presentation, etiopathogenesis, histopathology, and immunoprofile of intraoral HIV-associated Burkitt’s lymphoma is essential among clinicians and pathologists.
Abstract
Individuals with human immunodeficiency virus (HIV) infection present with unique intraoral manifestations of various neoplasms. Intraoral HIV-associated Burkitt’s lymphoma is a rare presentation, especially in patients of Indian origin and may present as an initial sign of HIV. The objective of this paper is to report a rare case of Burkitt’s lymphoma in an HIV-positive Indian patient along with a special emphasis on differential diagnosis. A 30-year-old Indian female presented with a solitary, well-defined, exophytic mass extending anteroposteriorly and buccolingually from the 35th to 38th regions with no evidence of intraosseous extension. An incisional biopsy was performed, and histopathology showed sheets of neoplastic lymphoid cells with numerous tingible body macrophages with clear cytoplasm, presenting a starry sky appearance, suggesting a diagnosis of BL. The tumor cells were positive for CD10, CD20, c-myc, and Epstein–Barr virus, with a nearly 100% Ki-67 proliferative index. The patient tested positive for HIV. This report indicates the importance of immunohistochemical analysis to differentiate Burkitt’s lymphoma from other similar lesions like diffuse large B-cell lymphoma. Thorough knowledge of the clinical presentation, etiopathogenesis, histopathology, and immunoprofile of intraoral HIV-associated Burkitt’s lymphoma is essential among clinicians and pathologists.
참고문헌 (20)
- Cesarman E, "Pathology of lymphoma in HIV", Curr Opin Oncol, 25, pp.487~494 (2013)
- Corti M, "Burkitt’s lymphoma associated with HIV infection", Clin Microbiol, 5, pp.232~ (2016)
- Ajila V, "Intraoral Burkitt’s lymphoma in an HIV positive patient", Indian J Sex Transm Dis AIDS, 33, pp.118~120 (2012)
- Swerdlow SH, "WHO classification of tumours of haematopoietic and lymphoid tissues" (2008), IARC Press
- Goto M, "Human immunodeficiency virus-associated Burkitt’s lymphoma in oral cavity of Japanese patient", J Oral Maxillofac Surg, 70, pp.1885~1890 (2012)
- Mosalleum E, "Oral medicine case book 69 : Burkitt lymphoma of the oral cavity", South Afr Dent J, 70, pp.168~170 (2015)
- Sivolella S, "Sporadic Burkitt lymphoma mimicking osteomyelitis of the mandible revealing clinically unsuspected HIV infection", Anticancer Res, 35, pp.4837~4839 (2015)
- Pinisetti S, "HIV associated intra-oral Burkitt’s lymphoma : a case report", J Clin Diagn Res, 7, pp.3088~3089 (2013)
- Silva TD, "Oral manifestations of lymphoma : a systematic review", Ecancermedicalscience, 10, pp.665~ (2016)
- Chen YK, "Intra-oral HIV-associated Burkitt’s lymphoma with mandible involvement", Oral Oncol Extra, 41, pp.249~252 (2005)
- Karlis V, "Right facial edema associated with localized gingival swelling", J Oral Maxillofac Surg, 56, pp.760~764 (1998)
- Jordan RC, "Oral lymphoma in human immunodeficiency virus infection : a report of six cases and review of the literature", Otolaryngol Head Neck Surg, 119, pp.672~677 (1998)
- Langford A, "Oral manifestations of AIDS-associated non-Hodgkin’s lymphomas", Int J Oral Maxillofac Surg, 20, pp.136~141 (1991)
- Corti M, "Non-Hodgkin lymphomas of the oral cavity in AIDS patients in a reference hospital of infectious diseases in Argentina : report of eleven cases and review of the literature", J Gastrointest Cancer, 42, pp.143~148 (2011)
- Nittayananta W, "Burkitt-like lymphoma presenting as a periodontal disease in AIDS patients : a report of two cases", Oral Dis, 4, pp.281~284 (1998)
- Venkatesh E, "Oral non-Hodgkin’s lymphoma as an initial diagnosis in a HIV positive patient", J Indian Acad Oral Med Radiol, 20, pp.162~165 (2008)
- Komatsu N, "HIV-associated Burkitt lymphoma in a Japanese patient with early submandibular swelling", BMC Res Notes, 6, pp.557~ (2013)
- Butt FM, "Pattern of head and neck malignant neoplasms in HIV-infected patients in Kenya", Int J Oral Maxillofac Surg, 37, pp.907~911 (2008)
- Bellan C, "Burkitt lymphoma versus diffuse large B-cell lymphoma : a practical approach", Hematol Oncol, 28, pp.53~56 (2010)
- Rosenwald A, "Burkitt lymphoma versus diffuse large B-cell lymphoma", Ann Oncol, 19(Suppl 4), pp.iv67~iv69 (2008)