Long-term mortality of adult patients with carbon monoxide poisoning presenting to the emergency department in Korea: a population-based cohort study
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Carbon monoxide (CO) poisoning can lead to significant morbidity and mortality. However, relatively few studies have investigated its long-term mortality impact. This nationwide population-based cohort study examined the association between CO poisoning and long-term mortality.Methods: This retrospective study utilized data from the National Health Insurance Service database in South Korea. We compared the patients with CO poisoning to those without CO poisoning. Inverse probability treatment weights were applied to both groups to control for potential confounding factors. Subsequently, mortality was assessed using the incidence rate and Cox proportional hazard ratios.Results: This study included 23,387 patients with CO poisoning and 359,851 without it. Over a median follow-up period of 7.6 years after CO poisoning diagnosis, the mortality risk was 2.6 times higher in patients with CO poisoning compared to that in the control group. In a long-term follow-up of patients surviving beyond 30 days, mortality remained 2.18 times higher. Additionally, a higher mortality risk was observed in the relatively younger age group (18–39 years) and the group with fewer underlying diseases, as indicated by a Charlson Comorbidity Index score of 0.Conclusions: CO poisoning is associated with an elevated long-term mortality rate particularly in a relatively young and healthy population.
Abstract
Background: Carbon monoxide (CO) poisoning can lead to significant morbidity and mortality. However, relatively few studies have investigated its long-term mortality impact. This nationwide population-based cohort study examined the association between CO poisoning and long-term mortality.Methods: This retrospective study utilized data from the National Health Insurance Service database in South Korea. We compared the patients with CO poisoning to those without CO poisoning. Inverse probability treatment weights were applied to both groups to control for potential confounding factors. Subsequently, mortality was assessed using the incidence rate and Cox proportional hazard ratios.Results: This study included 23,387 patients with CO poisoning and 359,851 without it. Over a median follow-up period of 7.6 years after CO poisoning diagnosis, the mortality risk was 2.6 times higher in patients with CO poisoning compared to that in the control group. In a long-term follow-up of patients surviving beyond 30 days, mortality remained 2.18 times higher. Additionally, a higher mortality risk was observed in the relatively younger age group (18–39 years) and the group with fewer underlying diseases, as indicated by a Charlson Comorbidity Index score of 0.Conclusions: CO poisoning is associated with an elevated long-term mortality rate particularly in a relatively young and healthy population.
참고문헌 (27)
- Mattiuzzi C, "Worldwide epidemiology of carbon monoxide poisoning", Hum Exp Toxicol, 39, pp.387~392 (2020)
- Huang CC, "Demographic and clinical characteristics of carbon monoxide poisoning : nationwide data between 1999 and 2012 in Taiwan", Scand J Trauma Resusc Emerg Med, 25, pp.70~ (2017)
- Choi YR, "Suicide from carbon monoxide poisoning in South Korea : 2006-2012", J Affect Disord, 167, pp.322~325 (2014)
- Cui P, "Burden of carbon monoxide poisoning in China, 1990-2019 : a systematic analysis of data from the global burden of disease study 2019", Front Public Health, 10, pp.930784~ (2022)
- Bae S, "Epidemiologic characteristics of carbon monoxide poisoning : emergency department based injury in-depth surveillance of twenty hospitals", J Korean Soc Clin Toxicol, 14, pp.122~128 (2016)
- Kim YJ, "Carbon monoxide poisoning during camping in Korea", Inhal Toxicol, 28, pp.719~723 (2016)
- Rose JJ, "Carbon monoxide poisoning : pathogenesis, management, and future directions of therapy", Am J Respir Crit Care Med, 195, pp.596~606 (2017)
- Meng YH, "Effect of carbon monoxide poisoning on epilepsy development : a nationwide population-based cohort study", Ann Emerg Med, 82, pp.14551~ (2023)
- Cho Y, "Risk of venous thromboembolism after carbon monoxide poisoning : a nationwide population-based study", Ann Emerg Med, 75, pp.587~596 (2020)
- Ostrowski RP, "Risk factors for short-term mortality from carbon monoxide poisoning treated with hyperbaric oxygen", Crit Care Med, 36, pp.2684~2685 (2008)
- Rhee B, "Incidence patterns of nervous system diseases after carbon monoxide poisoning : a retrospective longitudinal study in South Korea from 2012 to 2018", Clin Exp Emerg Med, 8, pp.111~119 (2021)
- Lee Y, "Serum phosphate is not an early predictor of neurocognitive outcomes in acute carbon monoxide poisoning patients", Clin Exp Emerg Med, 10, pp.74~83 (2023)
- Moon JS, "Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning", Clin Exp Emerg Med, 9, pp.230~237 (2022)
- Weaver LK, "Clinical practice. Carbon monoxide poisoning", N Engl J Med, 360, pp.1217~1225 (2009)
- Huang CC, "Long-term prognosis of patients with carbon monoxide poisoning : a nationwide cohort study", PLoS One, 9, pp.e105503~ (2014)
- Huang CC, "Risk of myocardial infarction after carbon monoxide poisoning : a nationwide population-based cohort study", Cardiovasc Toxicol, 19, pp.147~155 (2019)
- Cho DH, "Myocardial injury and fibrosis from acute carbon monoxide poisoning : a prospective observational study", JACC Cardiovasc Imaging, 14, pp.1758~1770 (2021)
- Kwak K, "Association between carbon monoxide intoxication and incidence of ischemic stroke : a retrospective nested case-control study in South Korea", J Stroke Cerebrovasc Dis, 30, pp.105496~ (2021)
- Huang CC, "Association between carbon monoxide poisoning and adrenal insufficiency : a nationwide cohort study", Sci Rep, 12, pp.16219~ (2022)
- Lee S, "Trends of carbon monoxide poisoning patients in emergency department : NEDIS(National Emergency Department Information System)", J Korean Soc Emerg Med, 32, pp.27~35 (2021)
- Carter GL, "Can the Edinburgh risk of repetition scale predict repetition of deliberate self-poisoning in an Australian clinical setting?", Suicide Life Threat Behav, 32, pp.230~239 (2002)
- Kim H, "Early psychiatric referral after attempted suicide helps prevent suicide reattempts : a longitudinal national cohort study in South Korea", Front Psychiatry, 13, pp.607892~ (2022)
- 2021 White paper on suicide prevention, "Ministry of Health and Welfare", Korea Foundation for Suicide Prevention, ~ (2021)
- "Cause of death statistics" (2023)[URL]
- Jung HW, "How public and private health insurance coverage mitigates catastrophic health expenditures in Republic of Korea", BMC Health Serv Res, 22, pp.1042~ (2022)
- Kwon KN, "Effects of private health insurance on medical expenditure and health service utilization in South Korea : a quantile regression analysis", BMC Health Serv Res, 23, pp.1219~ (2023)
- Baek EM, "The effect of additional private health insurance on mortality in the context of universal public health insurance", Int J Environ Res Public Health, 18, pp.8363~ (2021)