Human Papillomavirus에 감염된에이즈 환자에게 발생한 항문암 2예
Two Cases of Anal Cancer in Patient with Acquired Immunodeficiency SyndromeInfected by Human Papillomavirus
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항문암은 HIV 감염자에게 발생하는 빈도가 비감염자에 비해 더 높다. HIV 감염자에게 항문암의 발생 빈도가 더 높은 까닭은 항문 성교와 이로 인해서 발생하는 human papillomavirus (HPV) 감염이 이들 환자에게 더 흔하기 때문이라고 생각한다. 항문의 농양, 첨규 콘딜로마로 내원한 HIV 감염자에게서 항문암을 진단하였으며, 이 환자로부터 2년 전에 수술로 떼어낸 첨규 콘딜로마 조직에서 HPV 유전형 69를 발견하였다. 또한, 항문 출혈로 병원을 방문한 HIV 감염자에게서 항문암을 진단하였으며, 조직 생검으로 얻은 종양 조직에서 HPV 유전형 16를 발견하였다. HIV 감염자에게 항문의 농양, 첨규 콘딜로마, 항문 출혈 등의 임상 증상이 발생하면 HPV와 관련된 항문암을 감별해야 하겠다.
Abstract
We report two cases of anal cancer in patient with acquired immunodeficiency syndrome infected by human papillomavirus (HPV). One patient presented with huge anal abscess of long duration which developed after incomplete resection of anal warts 2 years ago and the other patient presented with anal bleeding. They were diagnosed as having anal squamous cell carcinoma. Highly oncogenic HPV 69 and 16 were detected by HPV-DNA chip on the previous specimen of warts and anal cancer tissue, respectively. The possibility of anal cancer should be considered in patients infected with human immunodeficiency virus who present anal problems such as anal abscess, anal bleeding, or condyloma accuminatum in anus.
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