Erythromycin 내성 포도알균의 유도형 Macrolide-Lincosamide- Streptogramin B (MLSB) 내성 표현형 빈도
Prevalence of Inducible Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in Erythromycin-Resistant Staphylococci
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Inducible MLSB (macrolide-lincosamide-streptogramin B) resistance in staphylococci is not detected by standard susceptibility test methods. Failure to identify inducible MLSB resistance may lead to clinical failure during clindamycin therapy. We determined the prevalence of inducible MLSB resistance in erythromycin-resistant staphylococcal isolates. Materials and Methods: We evaluated all 2,792 non-duplicate staphylococcal strains: 1,402 Staphylococcus aureus and 1,390 coagulase-negative staphylococci (CoNS) isolated from May 2008-June 2009 at one-unoversity hospital. Testing for inducible MLSB was accomplished by the disk approximation test (D-test) in accordance with the recommendations of the Clinical and Laboratory Standards Institute (CLSI). Results: Of the 2,792 staphylococcal isolates, 892 S. aureus isolates and 740 CoNS isolates were resistant to erythromycin. Among the 892 erythromycin-resistant S. aureus isolates, the overall prevalence of inducible MLSB was 21.3% (16.2% of MRSA and 76.3% of methicillin-susceptible S. aureus). Among the 740 erythromycinresistant CoNS isolates, the overall prevalence of inducible MLSB was 16.5% (16.0%of methicillin-resistant CoNS and 18.7% of methicillin-susceptible CoNS). The D-test was positive in 88.8% of S. aureus and 28.4% of CoNS isolates, which were erythromycin-resistant and clindamycin-susceptible. Conclusions: There are some variations in the prevalence of inducible MLSB resistance in clinical staphylococcal isolates. It is important that clinical laboratories report inducible MLSB resistance for erythromycin-resistant and clindamycinsusceptible staphylococcal isolates.
Abstract
Background: Inducible MLSB (macrolide-lincosamide-streptogramin B) resistance in staphylococci is not detected by standard susceptibility test methods. Failure to identify inducible MLSB resistance may lead to clinical failure during clindamycin therapy. We determined the prevalence of inducible MLSB resistance in erythromycin-resistant staphylococcal isolates. Materials and Methods: We evaluated all 2,792 non-duplicate staphylococcal strains: 1,402 Staphylococcus aureus and 1,390 coagulase-negative staphylococci (CoNS) isolated from May 2008-June 2009 at one-unoversity hospital. Testing for inducible MLSB was accomplished by the disk approximation test (D-test) in accordance with the recommendations of the Clinical and Laboratory Standards Institute (CLSI). Results: Of the 2,792 staphylococcal isolates, 892 S. aureus isolates and 740 CoNS isolates were resistant to erythromycin. Among the 892 erythromycin-resistant S. aureus isolates, the overall prevalence of inducible MLSB was 21.3% (16.2% of MRSA and 76.3% of methicillin-susceptible S. aureus). Among the 740 erythromycinresistant CoNS isolates, the overall prevalence of inducible MLSB was 16.5% (16.0%of methicillin-resistant CoNS and 18.7% of methicillin-susceptible CoNS). The D-test was positive in 88.8% of S. aureus and 28.4% of CoNS isolates, which were erythromycin-resistant and clindamycin-susceptible. Conclusions: There are some variations in the prevalence of inducible MLSB resistance in clinical staphylococcal isolates. It is important that clinical laboratories report inducible MLSB resistance for erythromycin-resistant and clindamycinsusceptible staphylococcal isolates.
참고문헌 (22)
- Fiebelkorn KR, "Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci", J Clin Microbiol, 41, pp.4740~4744 (2003)
- O’Sullivan MV, "Influence of disk separation distance on accuracy of the disk approximation test for detection of inducible clindamycin resistance in Staphylococcus spp", J Clin Microbiol, 44, pp.4072~4076 (2006)
- Steward CD, "Testing for induction of clindamycin resistance in erythromycin-resistant isolates of Staphylococcus aureus", J Clin Microbiol, 43, pp.1716~1721 (2005)
- Patel M, "Prevalence of inducible clindamycin resistance among community - and hospital-associated Staphylococcus aureus isolates", J Clin Microbiol, 44, pp.2481~2484 (2006)
- Cetin ES, "Macrolidelincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates", Int J Antimicrob Agents, 31, pp.364~368 (2008)
- Aktas Z, "Resistance to macrolide, lincosamide and streptogramin antibiotics in staphylococci isolated in Istanbul, Turkey", J Microbiol, 45, pp.286~290 (2007)
- Lewis JS 2nd, "Inducible clindamycin resistance in Staphylococci: should clinicians and microbiologists be concerned?", Clin Infect Dis, 40, pp.280~285 (2005)
- Jorgensen JH, "Detection of inducible clindamycin resistance of staphylococci in conjunction with performance of automated broth susceptibility testing", J Clin Microbiol, 42, pp.1800~1802 (2004)
- Siberry GK, "Failure of clindamycin treatment of methicillin-resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro", Clin Infect Dis, 37, pp.1257~1260 (2003)
- Frank AL, "Clindamycin treatment of methicillin-resistant Staphylococcus aureus infections in children", Pediatr Infect Dis J, 21, pp.530~534 (2002)
- Drinkovic D, "Clindamycin treatment of Staphylococcus aureus expressing inducible clindamycin resistance", J Antimicrob Chemother, 48, pp.315~316 (2001)
- Performance standards for antimicrobial susceptibility testing; nineteenth informational supplement, "Clinical and Laboratory Standards Institute", Clinical and Laboratory Standards Institute, ~, pp.CLSI document M100-S19 (2009)
- Lim JA, "Prevalence of resistance to macrolide, lincosamide and streptogramin antibiotics in Gram-positive cocci isolated in a Korean hospital", J Antimicrob Chemother, 49, pp.489~495 (2002)
- 어영, "Distributions of Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Clinical Isolates of Staphylococi", 대한임상미생물학회지, 11(2), pp.78~83 (2008), 대한임상미생물학회
- Kim HB, "A high frequency of macrolidelincosamide- streptogramin resistance determinants in Staphylococcus aureus isolated in South Korea", Microb Drug Resist, 10, pp.248~254 (2004)
- 김재석, "국내 13개 의료기관에서 수집된 Staphylococcus aureus의 항균제 감수성 양상", The Korean Journal of Laboratory Medicine, 24(4), pp.223~229 (2004), 대한진단검사의학회
- Bemer P, "Correlation of agar dilution and VITEK2 system for detection of resistance to macrolides, lincosamides and pristinamycin among Staphylococcus aureus and Staphylococcus epidermidis: association with genotypes", Clin Microbiol Infect, 11, pp.656~661 (2005)
- Chavez-Bueno S, "Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas", Antimicrob Agents Chemother, 49, pp.2283~2288 (2005)
- Otsuka T, "Macrolide-lincosamide-streptogramin B resistance phenotypes and genotypes among Staphylococcus aureus clinical isolates in Japan", Clin Microbiol Infect, 13, pp.325~327 (2007)
- Daurel C, "Differences in potential for selection of clindamycinresistant mutants between inducible erm (A) and erm (C) Staphylococcus aureus genes", J Clin Microbiol, 46, pp.546~550 (2008)
- Schreckenberger PC, "Incidence of constitutive and inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci in a community and a tertiary care hospital", J Clin Microbiol, 42, pp.2777~2779 (2004)
- Levin TP, "Potential clindamycin resistance in clindamycin-susceptible, erythromycinresistant Staphylococcus aureus: report of a clinical failure", Antimicrob Agents Chemother, 49, pp.1222~1224 (2005)