한국 군인에서 중증 아데노바이러스 폐렴의 임상 양상
A Clinical features of Severe Adenovirus Pneumonia among Members of the Korea Military : A Case Series
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Background: Adenoviral diseases generally present as self-limiting upper respiratory illnesses. However, in some cases, adenovirus can cause fatal outcomes, even in healthy adults. Severe pneumonia caused by adenovirus in young soldiers at basic military training sites have been reported. Materials and Methods: We conducted a retrospective review of the medical records of patients with pneumonia who were hospitalized in the Intensive Care Unit of the Armed Forces Capital Hospital between January 2011 and March 2012. Results: Nine patients with pneumonia who required ventilator treatment were analyzed. Adenovirus was proved to be the causative agent of the illness in six out of nine patients, three of whom died due to severe adenoviral pneumonia or adenovirus-related illness. Among these six patients, three were military trainees. Clinical features were characterized by fever (100%) and cough (100%). Other important findings included thrombocytopenia (83.3%), leukopenia (66.6%), and radiologically lobar consolidation (66.7%). Conclusions: Adenovirus appeared to be the most important pathogen of young Korean soldiers, particularly among military trainees with severe pneumonia requiring mechanical ventilation. Outbreak surveillance for adenovirus associated illness is necessary
Abstract
Background: Adenoviral diseases generally present as self-limiting upper respiratory illnesses. However, in some cases, adenovirus can cause fatal outcomes, even in healthy adults. Severe pneumonia caused by adenovirus in young soldiers at basic military training sites have been reported. Materials and Methods: We conducted a retrospective review of the medical records of patients with pneumonia who were hospitalized in the Intensive Care Unit of the Armed Forces Capital Hospital between January 2011 and March 2012. Results: Nine patients with pneumonia who required ventilator treatment were analyzed. Adenovirus was proved to be the causative agent of the illness in six out of nine patients, three of whom died due to severe adenoviral pneumonia or adenovirus-related illness. Among these six patients, three were military trainees. Clinical features were characterized by fever (100%) and cough (100%). Other important findings included thrombocytopenia (83.3%), leukopenia (66.6%), and radiologically lobar consolidation (66.7%). Conclusions: Adenovirus appeared to be the most important pathogen of young Korean soldiers, particularly among military trainees with severe pneumonia requiring mechanical ventilation. Outbreak surveillance for adenovirus associated illness is necessary
참고문헌 (21)
- Lynch JP 3rd., "Adenovirus", Semin Respir Crit Care Med, 32, pp.494~511 (2011)
- Rhee EG., "Adenoviruses, In Principles and practice of infectious disease. 7th ed", pp.2029~2030 (2009), Churchill Livingstone
- Ison MG., "Adenovirus infections in transplant recipients", Clin Infect Dis, 43, pp.331~339 (2006)
- Kim YJ., "Community respiratory virus infections in immunocompromised patients : hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection", Semin Respir Crit Care Med, 28, pp.222~242 (2007)
- Dudding BA., "Fatal pneumonia associated with adenovirus type 7 in three military trainees", N Engl J Med, 286, pp.1289~1292 (1972)
- Pingleton SK., "Type 3 adenoviral pneumonia occurring in a respiratory intensive care unit", Chest, 73, pp.554~555 (1978)
- Klinger JR., "Multiple cases of life-threatening adenovirus pneumonia in a mental health care center", Am J Respir Crit Care Med, 157, pp.645~649 (1998)
- Hilleman MR., "Epidemiologic investigations with respiratory disease virus RI-67", Am J Public Health Nations Health, 45, pp.203~210 (1955)
- Friedman M., "Studies on acute respiratory illness in naval recruits, with emphasis on the adenoviruses", J Infect Dis, 99, pp.182~187 (1956)
- Jeon K., "High isolation rate of adenovirus serotype 7 from South Korean military recruits with mild acute respiratory disease", Eur J Clin Microbiol Infect Dis, 26, pp.481~483 (2007)
- Brosch L., "Adenovirus serotype 14 pneumonia at a basic military training site in the United States, spring 2007 : a case series", Mil Med, 174, pp.1295~1299 (2009)
- Kolavic-Gray SA., "Large epidemic of adenovirus type 4 infection among military trainees : epidemiological, clinical, and laboratory studies", Clin Infect Dis, 35, pp.808~818 (2002)
- Kim JH., "Viral etiology of communityacquired pneumonia in Korean adults", Korean J Infect Dis, 33, pp.8~14 (2001)
- Kim CK., "A study of adenovirus pneumonia : early summer outbreak in", Korean J Pediatr Infect Dis, 3, pp.145~153 (1996)
- Lee J., "Comprehensive serotyping and epidemiology of human adenovirus isolated from the respiratory tract of Korean children over 17 consecutive years(1991-2007)", J Med Virol, 82, pp.624~631 (2010)
- Hakim FA., "Severe adenovirus pneumonia in immunocompetent adults : a case report and review of the literature", Eur J Clin Microbiol Infect Dis, 27, pp.153~158 (2008)
- Naesens L., "Antiadenovirus activities of several classes of nucleoside and nucleotide analogues", Antimicrob Agents Chemother, 49, pp.1010~1016 (2005)
- Neofytos D., "Treatment of adenovirus disease in stem cell transplant recipients with cidofovir", Biol Blood Marrow Transplant, 13, pp.74~81 (2007)
- Gaydos CA., "Adenovirus vaccines in the U. S. military", Mil Med, 160, pp.300~304 (1995)
- Potter RN., "Adenovirusassociated deaths in US military during postvaccination period, 1999-2010", Emerg Infect Dis, 18, pp.507~509 (2012)
- "Vaccines, blood, and biologics. March 16, 2011 approval letter-adenovirus type 4 and type 7 vaccine, live, oral" (2012)[URL]