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Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis

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초록

Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These aresignificant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated withdysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cellsis increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations ofimmune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

Abstract

Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These aresignificant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated withdysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cellsis increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations ofimmune cells due to sepsis, as well as indicates plausible therapeutic opportunities.

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