Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study, administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, P = 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible.
Abstract
There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study, administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, P = 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible.
참고문헌 (11)
- Zhou F, "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China : a retrospective cohort study", Lancet, 395, pp.1054~1062 (2020)
- Xu K, "Factors associated with prolonged viral RNA shedding in patients with COVID-19", Clin Infect Dis (2020)
- Zhou B, "The duration of viral shedding of discharged patients with severe COVID-19", Clin Infect Dis (2020)
- Ki Ho Hong, "Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea", Annals of Laboratory Medicine, 40(5), pp.351~360 (2020), 대한진단검사의학회[DOI]
- Smith GB, "The ability of the National Early Warning Score(NEWS)to discriminate patients at risk of early cardiac arrest, unanticipated intensive care unit admission, and death", Resuscitation, 84, pp.465~470 (2013)
- ARDS Definition Task Force, "Acute respiratory distress syndrome : the Berlin Definition", JAMA, 307, pp.2526~2533 (2012)
- Singer M, "The third international consensus definitions for sepsis and septic shock(Sepsis-3)", JAMA, 315, pp.801~810 (2016)
- Mehta P, "COVID-19: consider cytokine storm syndromes and immunosuppression", Lancet, 395, pp.1033~1034 (2020)
- Boulware DR, "A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19", N Engl J Med (2020)
- Du X, "Duration for carrying SARS-CoV-2 in COVID-19 patients", J Infect, 81, pp.e78~e79 (2020)
- Liu Y, "Viral dynamics in mild and severe cases of COVID-19", Lancet Infect Dis, 20, pp.656~657 (2020)