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전신성 홍반성 루푸스 환자에서 발생한Varicella-zoster Virus (VZV) 폐렴 2예

VZV Pneumonia in Patients with Systemic Lupus Erythematosus

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참고문헌

주제분류내과학

초록

Varicella 폐렴은 VZV 감염의 가장 흔하고 심각한 합병증 중 하나로, 어른에게 흔하며 SLE 등 류마티스성 질환, 면역저하 환자들에게서 호발한다. 최근 항바이러스제제의 사용으로 사망률이 많이 감소하였지만 아직도 높은 이환율과 사망률을 보이고 있다. 따라서 앞으로도 지속적인 관심이 필요하고, 특히 정확한 선별검사법이나 효과적인 치료계획에 대한 연구, 호발조건이나 위험인자들의 발견, 그에 따른 고위험군에 대한 관리가 필요하다.

Abstract

Varicella-zoster virus (VZV) is a member of the herpesviridae, which shares the characteristics of latent infection and reactivation. VZV causes two distinct clinical entities; varicella (chickenpox) and herpes zoster (shingles). Varicella pneumonia is the most common complication of adult varicella, especially in patients who are immunocompromised. We present two cases of VZV pneumonia occuring in patients with systemic lupus erythematosus (SLE) who were being treated with cytotoxic drugs and steroid. Both patients were treated with acyclovir and responses were good.

참고문헌 (19)

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  15. "Varicella pneumonia in adults", 21, pp.886~91 (2003)
  16. "Varicella-Zoster virus detection by polymerase chain reaction using bronchoalveolar lavage specimens", 162, pp.753~4 (2000)
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  18. "Mechanisms of action and clinical considerations", pp.304~15 (1976)
  19. "Herpes zoster infections in systemic lupus erythematosus", pp.84~6 (1994)

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