골육종 환자에서 발생한 Clostridium sordellii 균혈증 1예
A Case of Clostridium sordellii Bacteremia in a Patient with Osteosarcoma
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초록
Clostridium sordellii는 다른 Clostridium 종에 비하여 인체 감염을 유발하는 경우가 드문데, 균혈증은 세계적으로 몇 개의 증례만이 보고되었으며 국내에선 아직 보고된 바 없다. 악성종양이나 면역 저하 환자에서 주로 발생하는 C. sordellii 균혈증은 특히 심부 감염에 동반된 경우 사망률이 높다. 저자 등은 골육종 환부의 연조직 감염과 관련된 C. sordellii 균혈증 1예를 경험하여 보고하는 바이다.
Abstract
Clostridium sordellii is a gram-positive spore forming anaerobic bacillus, rarely encountered in human infection. It produces several exotoxins which contribute to myonecrosis, pulmonary infection, obstetric infection and bacteremia. C. sordellii bacteremia is very rare and has been reported in few patients with malignancy or immunosuppression. To date, there has been no report in Korea. Mortality is high when deep site infection exists regardless of underlying pathology and immune status. In contrast, superficial skin and subcutaneous tissue infection has a favorable prognosis. We present a case of C. sordellii bacteremia in a patient with osteosarcoma. The patient was admitted for the treatment of the infection at the ulcerative osteosarcoma lesions of the leg, and C. sordellii bacteremia was demonstrated. He was successfully treated with intravenous ampicillin/sulbactam for two weeks.
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