대유행 인플루엔자(H1N1 2009) 치료에서 Oseltamivir내성을 보인 1예
A Case of Oseltamivir-resistant Pandemic Influenza (H1N1 2009)
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In April 2009, the first swine origin pandemic influenza (H1N1 2009) infection was reported in Mexico and United states and has since spread rapidly worldwide. Finally on June 11, 2009, WHO officially declared the first pandemic of the 21st century. Until March 2010, more than 213 countries reported laboratory confirmed cases of pandemic influenza H1N1 2009,including at least 16,931 deaths. The drug of choice for treatment and prophylaxis of pandemic (H1N1) 2009 influenza are the neuraminidase inhibitor (oseltamivir and Zanamivir). However, increased use of these drugs lead to the emergence of oseltamivir-resistant strains. We report a case of oseltamivirresistant pandemic influenza (H1N1 2009) virus infection in a patient who were initially started with oseltamivir for laboratory-confirmed influenza. Patient's symptoms worsened despite the use of high-dose oral oseltamivir, and antiviral susceptibility test showed oseltamivir resistance (H275Y mutation). The patient resolved after treatment with zanamivir.
Abstract
In April 2009, the first swine origin pandemic influenza (H1N1 2009) infection was reported in Mexico and United states and has since spread rapidly worldwide. Finally on June 11, 2009, WHO officially declared the first pandemic of the 21st century. Until March 2010, more than 213 countries reported laboratory confirmed cases of pandemic influenza H1N1 2009,including at least 16,931 deaths. The drug of choice for treatment and prophylaxis of pandemic (H1N1) 2009 influenza are the neuraminidase inhibitor (oseltamivir and Zanamivir). However, increased use of these drugs lead to the emergence of oseltamivir-resistant strains. We report a case of oseltamivirresistant pandemic influenza (H1N1 2009) virus infection in a patient who were initially started with oseltamivir for laboratory-confirmed influenza. Patient's symptoms worsened despite the use of high-dose oral oseltamivir, and antiviral susceptibility test showed oseltamivir resistance (H275Y mutation). The patient resolved after treatment with zanamivir.
참고문헌 (10)
- "World now at the start of 2009 influenza pandemic"[URL]
- "Pandemic(H1N1) 2009. Disease outbreak news - situation update 93"[URL]
- WHO, "Pandemic (H1N1) 2009 briefing note 1: Viruses resistant to oseltamivir (Tamif lu) identified", Wkly Epidemiol Rec, 84, pp.299~399 (2009)
- "Pandemic(H1N1) 2009. antiviral drug resistance"[URL]
- "Epidemiological study of five patients with oseltamivirresistant Influenza A(H1N1) in Korea. Public health weekly report"[URL]
- Centers for Disease Control and Prevention (CDC), "Update: drug susceptibility of swine-origin influenza A (H1N1) viruses, April 2009", MMWR Morb Mortal Wkly, 58, pp.433~435 (2009)
- "A weekly influenza surveillance report: 2009-2010 influenza season week 14 ending April 10, 2010"[URL]
- Moscona A, "Global transmission of oseltamivir-resistant influenza", N Engl J Med, 360, pp.953~956 (2009)
- Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, "Emergence of a novel swine-origin influenza A (H1N1) virus in humans", N Engl J Med, 360, pp.2605~2615 (2009)
- Choi WY, "Amantadine-resistant influenza A viruses isolated in South Korea from 2003 to 2009", Antiviral Research, 84, pp.199~202 (2009)