A Case of Immune Reconstitution Inflammatory Syndrome in AIDS-related Progressive Multifocal Leukoencephalopathy after Antiretroviral Therapy
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system due to JC virus. In acquired immunodeficiency syndrome (AIDS) patients, JC virus infects myelin-producing oligodendrocytes causing a noninflammatory lytic reaction leading to demyelination and brain death. We herein report a case of a 56-years-old AIDS man who developed immune reconstitution inflammatory syndrome and died while undergoing highly active antiretroviral therapy. In this patient, the PML involved the brainstem, causing mental confusion followed by recurrent aspiration, adult respiratory distress syndrome, and eventually to early death.
Abstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system due to JC virus. In acquired immunodeficiency syndrome (AIDS) patients, JC virus infects myelin-producing oligodendrocytes causing a noninflammatory lytic reaction leading to demyelination and brain death. We herein report a case of a 56-years-old AIDS man who developed immune reconstitution inflammatory syndrome and died while undergoing highly active antiretroviral therapy. In this patient, the PML involved the brainstem, causing mental confusion followed by recurrent aspiration, adult respiratory distress syndrome, and eventually to early death.
참고문헌 (19)
- D'Amico R, "Immune reconstitution after potent antiretroviral therapy in AIDS patients with progressive multifocal leukoencephalopathy", Scand J Infect Dis, 39, pp.347~350 (2006)
- Martinez JV, "Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder", Neurology, 67, pp.1692~1694 (2006)
- Kraemer C, "Cidofovir in combination with HAART and survival in AIDS-associated progressive multifocal leukoencephalopathy", J Neurol, 255, pp.526~531 (2008)
- Gray F, "The changing pattern of HIV neuropathology in the HAART era", J Neuropathol Exp Neurol, 62, pp.429~440 (2003)
- Fedele CG, "Multiplex polymerase chain reaction for the simultaneous detection and typing of polyomavirus JC, BK and SV40 DNA in clinical samples", J Virol Methods, 82, pp.137~144 (1999)
- Berger JR, "Progressive multifocal leukoencephalopathy", Curr Neurol Neurosci Rep, 7, pp.461~469 (2007)
- Chukwudelunzu FE, "Progressive multifocal leukoencephalopathy as an initial manifestation of AIDS", Hosp Physician, 5, pp.65~70 (2001)
- Lee MH, "Progressive multifocal leukoencephalopathy in an AIDS patient", J Formos Med Assoc, 106(Suppl 3), pp.S24~S28 (2007)
- Aksamit AJ, "Progressive multifocal leukoencephalopathy", Curr Treat Options Neurol, 10, pp.178~185 (2008)
- Major EO, "Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain", Clin Microbiol Rev, 5, pp.49~73 (1992)
- Koralnik IJ, "New insights into progressive multifocal leukoencephalopathy", Curr Opin Neurol, 17, pp.365~370 (2004)
- Raina S, "Progressive multifocal leukoencephalopathy--as a presenting manifestation of AIDS", J Assoc Physicians India, 55, pp.797~801 (2007)
- Berger JR, "Progressive multifocal leukoencephalopathy: lessons from AIDS and natalizumab", Neurol Res, 28, pp.299~305 (2006)
- Berger JR, "Predictive factors for prolonged survival in acquired immunodeficiency syndrome-associated progressive multifocal leukoencephalopathy", Ann Neurol, 44, pp.341~349 (1998)
- Koralnik IJ, "JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy", J Virol, 75, pp.3483~3487 (2001)
- Agostini HT, "Genotype profile of human polyomavirus JC excreted in urine of immunocompetent individuals", J Clin Microbiol, 34, pp.159~164 (1996)
- De Luca A, "Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive multifocal leukoencephalopathy: a multicohort analysis", AIDS, 22, pp.1759~1767 (2008)
- Tan K, "PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids", Neurology, 72, pp.1458~1464 (2009)
- Berger JR, "Steroids for PML-IRIS: a double-edged sword?", Neurology, 72, pp.1454~1455 (2009)