새로운 항진균제의 국내 사용 및 전망
Current Usage and Prospect of New Antifungal agents in Korea
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초록
The incidence of invasive fungal infections has been increased worldwide along with the increasing population at high risk for fungal infection. However, no data is available for the current status of usage of antifungal agents in Korea. We described the usage of antifungal agents including second-generation triazole and echinocandins that have been recently introduced. Data from Health Insurance Review and Assessment Service were analyzed. Estimated total DDDs (daily defined doses)/1,000 patient-day of parenteral antifungal agents were 187.6 in 2008 and 143.2 in 2007 and annual rates of increase was 20% to 30% since 2004. Indeed, increased percentage of newer agents were observed. Changes of the treatment guidelines and the regulations for insurance coverage are considered to influence the trend of antifungal usage.
Abstract
The incidence of invasive fungal infections has been increased worldwide along with the increasing population at high risk for fungal infection. However, no data is available for the current status of usage of antifungal agents in Korea. We described the usage of antifungal agents including second-generation triazole and echinocandins that have been recently introduced. Data from Health Insurance Review and Assessment Service were analyzed. Estimated total DDDs (daily defined doses)/1,000 patient-day of parenteral antifungal agents were 187.6 in 2008 and 143.2 in 2007 and annual rates of increase was 20% to 30% since 2004. Indeed, increased percentage of newer agents were observed. Changes of the treatment guidelines and the regulations for insurance coverage are considered to influence the trend of antifungal usage.
참고문헌 (20)
- Kang MW, "Triazole antifungal drugs", Korean J Infect Dis, 22, pp.1~4 (1990)
- Woo JH, "Systemic antifungal agents", Korean J Med Mycol, 2, pp.110~122 (1997)
- Herbrecht R, "Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis", N Engl J Med, 347, pp.408~415 (2002)
- Walsh TJ, "Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia", N Engl J Med, 351, pp.1391~1402 (2004)
- van Burik JA, "Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation", Clin Infect Dis, 39, pp.1407~1416 (2004)
- Merlo J, "Comparison of dose standard units for drug utilisation studies", Eur J Clin Pharmacol, 50, pp.27~30 (1996)
- Cosentino M, "An approach for the estimation of drug prescribing using the defined daily dose methodology and drug dispensation data. Theoretical considerations and practical applications", Eur J Clin Pharmacol, 56, pp.513~517 (2000)
- Walsh TJ, "Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia", N Engl J Med, 340, pp.764~771 (1999)
- Fischer T, "Liposomal amphotericin B for fever and neutropenia", N Engl J Med, 341, pp.1152~ (1999)
- Prentice HG, "Liposomal amphotericin B for fever and neutropenia", N Engl J Med, 341, pp.1152~1153 (1999)
- Rakita R, "Liposomal amphotericin B for fever and neutropenia", N Engl J Med, 341, pp.1153~1154 (1999)
- Kontoyiannis DP, "Caspofungin versus liposomal amphotericin B for empirical therapy", N Engl J Med, 352, pp.410~414 (2005)
- Kim EC, "In vitro activity of antifungal agents against clinical isolates of yeasts", J Korean Soc Chemother, 16, pp.215~220 (1998)
- Lee MK, "Susceptibility and trailing growth of Candida albicans to fluconazole: results of a Korean multicentre study", Mycoses, 50, pp.148~149 (2007)
- 이진솔, "Species Distribution and Susceptibility to Azole Antifungals of Candida Bloodstream Isolates from Eight University Hospitals in Korea", Yonsei Medical Journal, 48(5), pp.779~786 (2007), 연세대학교의과대학
- Kim SH, "The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida: a multicenter Korean study", Med Mycol, 47, pp.296~304 (2009)
- Blot S, "Effect of fluconazole consumption on long-term trends in candidal ecology", J Antimicrob Chemother, 58, pp.474~477 (2006)
- 박지영, "CLSI 액체배지 미량희석법, Etest 및 Minimum Fungicidal Concentration 검사에 의한 국내 혈액에서 분리된 효모균의 시험관 내 Amphotericin B 내성 성적", The Korean Journal of Laboratory Medicine, 28(5), pp.346~352 (2008), 대한진단검의학회
- Forrest GN, "Increasing incidence of Candida parapsilosis candidemia with caspofungin usage", J Infect, 56, pp.126~129 (2008)
- Moeremans K, "Economic evaluation of intravenous itraconazole for presumed systemic fungal infections in neutropenic patients in Korea", International Journal of Hematology, 82, pp.251~258 (2005)