적절한 항생제 사용의 의미와 영향
The Meaning and Impact of Appropriate Use of Antibiotics
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Antibiotics, one of the most successful drugs in medicine, dramatically altered the prognoses of patients with bacterial infections. With faith in that power, antibiotics have been used thoughtlessly as therapy or prophylaxis for several decades. Improper or inadequate use of these miracle drugs accelerated the appearance of resistance and aided spread of bad bugs. Resistance is a global problem; therefore,appropriate use of antibiotics is now a global concern. Decreasing unnecessary use of antibiotics in primary care clinics and amending inadequate use in teaching hospitals are essential in the fight against resistance. Many approaches to this fight,including a nationwide campaign, governmental policies, guidelines for antibiotic use, and antibiotic restriction systems have already been settled in many countries,including Korea. Although resistance is a critical problem now and will be even more of a problem in the future, antibiotics are not drugs we can throw away. The only way to overcome this threat is wise use of antibiotics.
Abstract
Antibiotics, one of the most successful drugs in medicine, dramatically altered the prognoses of patients with bacterial infections. With faith in that power, antibiotics have been used thoughtlessly as therapy or prophylaxis for several decades. Improper or inadequate use of these miracle drugs accelerated the appearance of resistance and aided spread of bad bugs. Resistance is a global problem; therefore,appropriate use of antibiotics is now a global concern. Decreasing unnecessary use of antibiotics in primary care clinics and amending inadequate use in teaching hospitals are essential in the fight against resistance. Many approaches to this fight,including a nationwide campaign, governmental policies, guidelines for antibiotic use, and antibiotic restriction systems have already been settled in many countries,including Korea. Although resistance is a critical problem now and will be even more of a problem in the future, antibiotics are not drugs we can throw away. The only way to overcome this threat is wise use of antibiotics.
참고문헌 (26)
- Ulldemolins M., "Appropriateness in critical", Crit Care Clin, 27, pp.35~51 (2011)
- Fishman N., "Antimicrobial stewardship", Am J Med, 119(6 Suppl 1), pp.S53~S61 (2006)
- Kollef MH., "Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patients", Clin Infect Dis, 31(Suppl 4), pp.S131~S138 (2000)
- Vogelaers D., "ANTHICUS Study Investigators. Patterns of antimicrobial therapy in severenosocomial infections : empiric choices, proportion of appropriate therapy, and adaptation rates-a multicentre, observational survey in critically ill patients", Int J Antimicrob Agents, 35, pp.375~381 (2010)
- Schwaber MJ., "The effect of antimicrobial resistance on patient outcomes : importance of proper evaluation of appropriate therapy", Crit Care, 13, pp.106~ (2009)
- Rello J., "Optimal therapy for methicillin-resistant Staphylococcus aureus pneumonia : what is the best dosing regimen?", Chest, 130, pp.938~940 (2006)
- Gonzales R., "Excessive antibiotic use for acute respiratory infections in the United States", Clin Infect Dis, 33, pp.757~762 (2001)
- Steinman MA., "Changing use of antibiotics in community-based outpatient practice 1991-1999", Ann Intern Med, 138, pp.525~533 (2003)
- Kuyvenhoven MM., "Outpatient antibiotic prescriptions from 1992 to 2001 in The Netherlands", J Antimicrob Chemother, 52, pp.675~678 (2003)
- Hulscher ME., "Antibiotic use : how to improve it?", Int J Med Microbiol, 300, pp.351~356 (2010)
- 김백남, "우리나라 항생제 사용 실태", Infection and Chemotherapy, 44(4), pp.250~262 (2012), 대한감염학회
- Hulscher ME., "Antibiotic prescribing in hospital : a social and behavioral scientific approach", Lancet Infect Dis, 10, pp.167~175 (2010)
- Ibrahim EH., "The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcome in the ICU setting", Chest, 118, pp.146~155 (2000)
- Vallés J., "Community-acquired bloodstream infection in critically ill adult patients : impact of shock and inappropriate antibiotic therapy on survival", Chest, 123, pp.1615~1624 (2003)
- Kumar A., "Cooperative Antimicrobial Therapy of Septic Shock Database Research Group. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock", Chest, 136, pp.1237~1248 (2009)
- Dellinger RP., "International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine. Surviving Sepsis Campaign : international guidelines for management of severe sepsis and septic shock : 2008", Crit Care Med, 36, pp.296~327 (2008)
- Houck PM., "Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia", Arch Intern Med, 164, pp.637~644 (2004)
- Kumar A., "Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock", Crit Care Med, 34, pp.1589~96 (2006)
- Deresinski S., "Principles of antibiotic therapy in severe infection: optimizing the therapeutic approach by use of laboratory and clinical data", Clin Infect Dis, 45(Suppl 3), pp.S177~S183 (2007)
- Ramphal R., "Importance of adequate initial antimicrobial therapy", Chemotherapy, 51, pp.171~176 (2005)
- Goossens H., "ESAC Project Group. Outpatient antibiotic use in Europe and association with resistance : a cross-national database study", Lancet, 365, pp.579~587 (2005)
- Chen DK., "Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Canadian Bacterial Surveillance Network", N Engl J Med, 341, pp.233~239 (1999)
- Costelloe C., "Effect of antibiotic prescribing in primary care on antimicrobial resis tance in individual patients: systematic review and metaanalysis", BMJ, 340, pp.c2096~ (2010)
- Oppong R., "Resource use and costs of treating acute cough", lower respiratory tract infection in 13 European countries : results and challenges, 2011, pp.12, 319~329
- Huttner B., "CHAMP consortium. Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in outpatients in high-income countries", Lancet Infect Dis, 10, pp.17~31 (2010)
- Byl B., "Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia", Clin Infect Dis, 29, pp.60~66 (1999)