소아기에 발병한 성장호르몬결핍증 환자의 성인기에서의 재평가 및 성장호르몬 치료: 청소년기에서 성인기로의 이행기의 관리
Reassessment of GH Status and GH Therapy in Adults with Childhood-onset GHD: Transitional Care from Adolescence to Adulthood
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Adult growth hormone deficiency (GHD) is associated with increased morbidity and mortality and reduced quality of life. GH status should be reevaluated in the transitional age for continued treatment to complete somatic development. All children diagnosed with GHD should be retested by insulin provocative tests upon completion of skeletal growth. A low insulin-like growth factor (IGF)-I is a reliable diagnostic indicator of GHD in the presence of hypopituitarism, however, a normal IGF-I does not rule out GHD. When the diagnosis of adult GHD is established, continuation of GH therapy is strongly recommended. Continued GH treatment from adolescence into early adulthood may contribute to the attainment of a normal bone and muscle mass and contribute to a decrease of the cardiovascular risk of GHD adults. There is ongoing debate about nearly every aspect of GH therapy. (J Korean Soc Pediatr Endocrinol 2011;16:1-6)
Abstract
Adult growth hormone deficiency (GHD) is associated with increased morbidity and mortality and reduced quality of life. GH status should be reevaluated in the transitional age for continued treatment to complete somatic development. All children diagnosed with GHD should be retested by insulin provocative tests upon completion of skeletal growth. A low insulin-like growth factor (IGF)-I is a reliable diagnostic indicator of GHD in the presence of hypopituitarism, however, a normal IGF-I does not rule out GHD. When the diagnosis of adult GHD is established, continuation of GH therapy is strongly recommended. Continued GH treatment from adolescence into early adulthood may contribute to the attainment of a normal bone and muscle mass and contribute to a decrease of the cardiovascular risk of GHD adults. There is ongoing debate about nearly every aspect of GH therapy. (J Korean Soc Pediatr Endocrinol 2011;16:1-6)
참고문헌 (22)
- Leong GM, "Growth hormone deficiency: strategies and indications to continue growth hormone therapy in transition from adolescence to adult life", Horm Res, 60(1), pp.78~85 (2003)
- "Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency", J Clin Endocrinol Metab, 83, pp.379~381 (1998)
- Ho KK, "Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia", Eur J Endocrinol, 157, pp.695~700 (2007)
- 김성운, "성인 성장호르몬 결핍증의 진단과 치료:2006 미국 내분비학회 임상 가이드라인을 참조하여", 대한내분비학회지, 21(6), pp.460~475 (2006), 대한내분비학회
- Molitch ME, "Endocrine Society's Clinical Guidelines Subcommittee, Stephens PA. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline", J Clin Endocrinol Metab, 91, pp.1621~1634 (2006)
- Rutherford OM, "in skeletal muscle and body composition after discontinuation of growth hormone treatment in growth hormone deficient young adults", Clin Endocrinol (Oxf), 34, pp.469~475 (1991)
- Kołtowska-Häggström M, "Discontinuation of growth hormone (GH) treatment during the transition phase is an important factor determining the phenotype of young adults with nonidiopathic childhood-onset GH deficiency", J Clin Endocrinol Metab, 95, pp.2646~2654 (2010)
- Clayton PE, "European Society of Paediatric Endocrinology. Consensus statement on the management of the GH-treated adolescent in the transition to adult care", Eur J Endocrinol, 152, pp.165~170 (2005)
- Agha A, "Anterior pituitary dysfunction in survivors of traumatic brain injury", J Clin Endocrinol Metab, 89, pp.4929~4936 (2004)
- Casanueva FF, "New guidelines for the diagnosis of growth hormone deficiency in adults", Horm Res, 71(1), pp.112~115 (2009)
- Radovick S, "Approach to the growth hormone-deficient child during transition to adulthood", J Clin Endocrinol Metab, 92, pp.1195~1200 (2007)
- Hoybye C, "Impact of the primary aetiology upon the clinical outcome of adults with childhood-onset GH deficiency", Eur J Endocrinol, 157, pp.589~596 (2007)
- Sizonenko PC, "Diagnosis and management of growth hormone deficiency in childhood and adolescence. Part 1: diagnosis of growth hormone deficiency", Growth Horm IGF Res, 11, pp.137~165 (2001)
- 김동선, "성인 성장호르몬 결핍증", 대한내과학회지, 75(3), pp.257~261 (2008), 대한내과학회
- Nicolson A, "The prevalence of severe growth hormone deficiency in adults who received growth hormone replacement in childhood", Clin Endocrinol (Oxf), 44, pp.311~316 (1996)
- Attanasio AF, "Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group", J Clin Endocrinol Metab, 82, pp.82~88 (1997)
- Biller BM, "Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency", J Clin Endocrinol Metab, 87, pp.2067~2079 (2002)
- Aimaretti G, "Comparisons among old and new provocative tests of GH secretion in 178 normal adults", Eur J Endocrinol, 142, pp.347~352 (2000)
- Corneli G, "Growth hormone levels in the diagnosis of growth hormone deficiency in adulthood", Pituitary, 10, pp.141~149 (2007)
- Kwan AY, "IGF-I measurements in the diagnosis of adult growth hormone deficiency", Pituitary, 10, pp.151~157 (2007)
- Carroll PV, "Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review", J Clin Endocrinol Metab, 83, pp.382~395 (1998), Growth Hormone Research Society Scientific Committee
- Mauras N, "GH use in the transition of adolescence to adulthood", Endocr Dev, 18, pp.109~125 (2010)