본문 바로가기
KERD
논문KCI 등재

The current state of dyslipidemia in Korean children and adolescents and its management in clinical practice

1

조회

0

다운로드

5

인용

0

참고문헌

키워드

주제분류소아과학

초록

Cardiovascular disease (CVD) is a leading cause of death worldwide including Korea. The risk factors of CVD are known as positive family history of early CVD, obesity, hypertension,diabetes, and dyslipidemia. Among those, dyslipidemia is one of modifiable risk factors. Dyslipidemia starts in childhood and progress to adulthood. Furthermore, dyslipidemia cause atherosclerosis and is closely related to other CVD risks. On the rationale that early identification and control of pediatric dyslipidemia will reduce the risk and severity of CVD in adulthood, the National Heart, Lung, and Blood Institute guidelines expanded to universal screening for lipid levels. However, there was no guideline for lipid screening and management in Korean children and adolescents yet. This review deals with the rationale of early identification and control of pediatric dyslipidemia along with the current Korean status of pediatric dyslipidemia. This review also deals with how to screen, diagnosis, and treatment of pediatric dyslipidemia.

Abstract

Cardiovascular disease (CVD) is a leading cause of death worldwide including Korea. The risk factors of CVD are known as positive family history of early CVD, obesity, hypertension,diabetes, and dyslipidemia. Among those, dyslipidemia is one of modifiable risk factors. Dyslipidemia starts in childhood and progress to adulthood. Furthermore, dyslipidemia cause atherosclerosis and is closely related to other CVD risks. On the rationale that early identification and control of pediatric dyslipidemia will reduce the risk and severity of CVD in adulthood, the National Heart, Lung, and Blood Institute guidelines expanded to universal screening for lipid levels. However, there was no guideline for lipid screening and management in Korean children and adolescents yet. This review deals with the rationale of early identification and control of pediatric dyslipidemia along with the current Korean status of pediatric dyslipidemia. This review also deals with how to screen, diagnosis, and treatment of pediatric dyslipidemia.

참고문헌 (47)

  1. "The global burden of disease" (2004)[URL]
  2. "Annual report on the cause of death statistics" (2010)[URL]
  3. 이명하, "Prevalence of Dyslipidemia among Korean Adults: Korea National Health and Nutrition Survey 1998-2005", Diabetes and Metabolism Journal, 36(1), pp.43~55 (2012), 대한당뇨병학회
  4. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute, "Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report", Pediatrics, 128(5), pp.S213~S256 (2011)
  5. Daniels SR, "Committee on Nutrition. Lipid screening and cardiovascular health in childhood", Pediatrics, 122, pp.198~208 (2008)
  6. Kwiterovich PO Jr, "Recognition and management of dyslipidemia in children and adolescents", J Clin Endocrinol Metab, 93, pp.4200~4209 (2008)
  7. "National Cholesterol Education Program (NCEP): highlights of the report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents", Pediatrics, 89, pp.495~501 (1992)
  8. Kavey RE, "American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood", Circulation, 107, pp.1562~1566 (2003)
  9. McGill HC Jr, "Effects of nonlipid risk factors on atherosclerosis in youth with a favorable lipoprotein profile", Circulation, 103, pp.1546~1550 (2001)
  10. McGill HC Jr, "Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group", Arterioscler Thromb Vasc Biol, 20, pp.1998~2004 (2000)
  11. Berenson GS, "Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study", N Engl J Med, 338, pp.1650~1656 (1998)
  12. Li S, "Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study", JAMA, 290, pp.2271~2276 (2003)
  13. Juonala M, "Associations of dyslipidemias from childhood to adulthood with carotid intima-media thickness, elasticity, and brachial flow-mediated dilatation in adulthood: the Cardiovascular Risk in Young Finns Study", Arterioscler Thromb Vasc Biol, 28, pp.1012~1017 (2008)
  14. Bao W, "Usefulness of childhood low-density lipoprotein cholesterol level in predicting adult dyslipidemia and other cardiovascular risks. The Bogalusa Heart Study", Arch Intern Med, 156, pp.1315~1320 (1996)
  15. Christensen B, "Plasma cholesterol and triglyceride distributions in 13,665 children and adolescents: the Prevalence Study of the Lipid Research Clinics Program", Pediatr Res, 14, pp.194~202 (1980)
  16. Hickman TB, "Distributions and trends of serum lipid levels among United States children and adolescents ages 4-19 years: data from the Third National Health and Nutrition Examination Survey", Prev Med, 27, pp.879~890 (1998)
  17. Yang S, "Serum lipid concentrations, prevalence of dyslipidemia, and percentage eligible for pharmacological treatment of Korean children and adolescents; data from the Korea National Health and Nutrition Examination Survey IV (2007-2009)", PLoS One, 7, pp.e49253~ (2012)
  18. Ford ES, "Concentrations of lowdensity lipoprotein cholesterol and total cholesterol among children and adolescents in the United States", Circulation, 119, pp.1108~1115 (2009)
  19. 김신혜, "한국 청소년의 지질 농도와 이상지질혈증의 유병률", Endocrinology and Metabolism, 27(3), pp.208~216 (2012), 대한내분비학회
  20. Centers for Disease Control and Prevention, "Prevalence of abnormal lipid levels among youths: United States, 1999-2006", MMWR Morb Mortal Wkly Rep, 59, pp.29~33 (2010)
  21. Lim S, "Changes in metabolic syndrome in American and Korean youth, 1997-2008", Pediatrics, 131, pp.e214~e222 (2013)
  22. Kit BK, "Trends in serum lipids among US youths aged 6 to 19 years, 1988-2010", JAMA, 308, pp.591~600 (2012)
  23. Zimmet P, "The metabolic syndrome in children and adolescents: an IDF consensus report", Pediatr Diabetes, 8, pp.299~306 (2007)
  24. McBride PE., "Triglycerides and risk for coronary heart disease", JAMA, 298, pp.336~338 (2007)
  25. Patel A, "Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region", Circulation, 110, pp.2678~2686 (2004)
  26. Ritchie SK, "Universal versus targeted blood cholesterol screening among youth: The CARDIAC project", Pediatrics, 126, pp.260~265 (2010)
  27. "Screening for lipid disorders in children and adolescents" (2007)[URL]
  28. US Preventive Services Task Force, "Screening for lipid disorders in children: US Preventive Services Task Force recommendation statement", Pediatrics, 120, pp.e215~e219 (2007)
  29. Yu HH, "Direct measurement of LDL-C in children: performance of two surfactant-based methods in a general pediatric population", Clin Biochem, 33, pp.89~95 (2000)
  30. Srinivasan SR, "Utility of childhood non-high-density lipoprotein cholesterol levels in predicting adult dyslipidemia and other cardiovascular risks: the Bogalusa Heart Study", Pediatrics, 118, pp.201~206 (2006)
  31. Lee KH, "Serum lipids in children and adolescents with family history of coronary artery diseases", J Korean Pediatr Soc, 38, pp.482~492 (1995)
  32. Kavey RE, "Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research", J Cardiovasc Nurs, 22, pp.218~253 (2007)
  33. "School health medical examination guideline" (2008)[URL]
  34. Rainwater DL, "Lipid and apolipoprotein predictors of atherosclerosis in youth: apolipoprotein concentrations do not materially improve prediction of arterial lesions in PDAY subjects. The PDAY Research Group", Arterioscler Thromb Vasc Biol, 19, pp.753~761 (1999), The PDAY Research Group
  35. Manlhiot C, "Spectrum and management of hypertriglyceridemia among children in clinical practice", Pediatrics, 123, pp.458~465 (2009)
  36. Gidding SS, "Dietary recommendations for children and adolescents: a guide for practitioners: consensus statement from the American Heart Association", Circulation, 112, pp.2061~2075 (2005)
  37. Tammi A, "Effects of gender, apolipoprotein E phenotype and cholesterol-lowering by plant stanol esters in children: the STRIP study. Special Turku Coronary Risk Factor Intervention Project", Acta Paediatr, 91, pp.1155~1162 (2002)
  38. Laurin D, "Effects of a soy-protein beverage on plasma lipoproteins in children with familial hypercholesterolemia", Am J Clin Nutr, 54, pp.98~103 (1991)
  39. Engler MM, "Effect of docosahexaenoic acid on lipoprotein subclasses in hyperlipidemic children (the EARLY study)", Am J Cardiol, 95, pp.869~871 (2005)
  40. Hong HR, "Physical activity and metabolic syndrome in Korean children", Int J Sports Med, 30, pp.677~683 (2009)
  41. Shin KO, "Empirically derived major dietary patterns and their associations with overweight in Korean preschool children", Br J Nutr, 98, pp.416~421 (2007)
  42. McCrindle BW, "Summary of the American Heart Association's scientific statement on drug therapy of high-risk lipid abnormalities in children and adolescents", Arterioscler Thromb Vasc Biol, 27, pp.982~985 (2007)
  43. Wiegman A, "Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial", JAMA, 292, pp.331~337 (2004)
  44. McCrindle BW, "Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial", J Pediatr, 143, pp.74~80 (2003)
  45. de Jongh S, "Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized, doubleblind, placebo-controlled trial with simvastatin", Circulation, 106, pp.2231~2237 (2002)
  46. Tonstad S, "Efficacy and safety of cholestyramine therapy in peripubertal and prepubertal children with familial hypercholesterolemia", J Pediatr, 129, pp.42~49 (1996)
  47. Blagden MD, "Efficacy and safety of ezetimibe co-administered with atorvastatin in untreated patients with primary hypercholesterolaemia and coronary heart disease", Curr Med Res Opin, 23, pp.767~775 (2007)

관련 논문AI추천

Dyslipidemia in Children and Adolescents: When and How to Diagnose and Treat?윤정민대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2014 · 제17권 제2호Dyslipidemia in Children and Adolescents: Current Insights and Updated Treatment ApproachesSung Eun Kim대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2025 · 제28권 제3호2017 Clinical practice guidelines for dyslipidemia of Korean children and adolescentsChae Hyun Wook, Choi Jin-Ho, Hwang Il Tae, Kim Eun Young, Kim Jae Hyun, Kim Ji Young, Lim Jung Sub, Yi Kyung Hee, Yoo Jae-Ho대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2020 · 제25권 제4호Limitations of current screening methods for lipid disorders in Korean adolescents and a proposal for an effective detection method: a nationwide, cross-sectional studyCheong Ji In, Cheuh Hee Won, Shin Jung Hyun, Yoo Jae-Ho대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2020 · 제25권 제4호우리나라 소아청소년의 공복 혈중 지질 농도의 분포 및 참고범위의 타당성 검증권세영, 나영악대한임상검사과학회 · 대한임상검사과학회지2018 · 제50권 제3호The triglyceride-to-high density lipoprotein cholesterol ratio in overweight Korean children and adolescents강유선, 권은별, 유동윤, 유은경대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2017 · 제22권 제3호

이 간행물의 다른 논문 (7건)