Relationship between serum insulin-like growth factor-1, IGF binding protein-3 levels and body height before and after gonadotropin-releasing hormone agonist therapy
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: The gonadotropin-releasing hormone agonist (GnRHa) is widely used to treat patients with precocious puberty. However, its effect on growth is often difficult to predict because of the diverse nature of its causes and presentation. This study aims to show the impact of GnRHa treatment on insulin-like growth factor-1 (IGF-I) and IGF binding protein-3 (IGFBP-3) secretion, growth, and on other parameters that may help estimate the height velocity. Methods: Data from 60 girls (mean age, 8.8±0.7 years) treated with GnRHa were analyzed. Their height, bone age (BA), serum IGF-I, and IGFBP-3 concentrations were measured at the start and after a year of GnRHa treatment. To eliminate the confounding effect of chronological age (CA), the standard deviation scores (SDSs) of their height, IGF-I, and IGFBP-3 concentrations according to their CA at the start and after a year of GnRHa treatment were calculated. We looked for possible correlations between these variables and compared the subgroups based on their height velocities and midparental heights. Results: During their one-year GnRHa therapy, height SDS for CA significantly decreased to 0.81±0.83 (P<0.001), but height SDS for BA increased to –0.28±0.68 (P<0.001). There was no significant change in serum IGF-I SDS, IGFBP-3 SDS, and IGF-I/IGFBP-3 ratio. The advanced BA was the factor most strongly correlated to the height velocity (R=0.265, P=0.041). Conclusion: These findings suggest that GnRHa treatment may affect the height velocity due to mechanisms other than suppression of the IGF-I and IGFBP-3 secretory axis.
Abstract
Purpose: The gonadotropin-releasing hormone agonist (GnRHa) is widely used to treat patients with precocious puberty. However, its effect on growth is often difficult to predict because of the diverse nature of its causes and presentation. This study aims to show the impact of GnRHa treatment on insulin-like growth factor-1 (IGF-I) and IGF binding protein-3 (IGFBP-3) secretion, growth, and on other parameters that may help estimate the height velocity. Methods: Data from 60 girls (mean age, 8.8±0.7 years) treated with GnRHa were analyzed. Their height, bone age (BA), serum IGF-I, and IGFBP-3 concentrations were measured at the start and after a year of GnRHa treatment. To eliminate the confounding effect of chronological age (CA), the standard deviation scores (SDSs) of their height, IGF-I, and IGFBP-3 concentrations according to their CA at the start and after a year of GnRHa treatment were calculated. We looked for possible correlations between these variables and compared the subgroups based on their height velocities and midparental heights. Results: During their one-year GnRHa therapy, height SDS for CA significantly decreased to 0.81±0.83 (P<0.001), but height SDS for BA increased to –0.28±0.68 (P<0.001). There was no significant change in serum IGF-I SDS, IGFBP-3 SDS, and IGF-I/IGFBP-3 ratio. The advanced BA was the factor most strongly correlated to the height velocity (R=0.265, P=0.041). Conclusion: These findings suggest that GnRHa treatment may affect the height velocity due to mechanisms other than suppression of the IGF-I and IGFBP-3 secretory axis.
참고문헌 (31)
- Grumba ch MM, "Williams textbook of endocrinology", pp.1509~625 (1998), Saunders
- Chalumeau M, "Central precocious puberty in girls: an evidence-based diagnosis tree to predict central nervous system abnormalities", Pediatrics, 109, pp.61~67 (2002)
- Mogensen SS, "Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty", J Clin Endocrinol Metab, 96, pp.1393~1401 (2011)
- 김한결, "Gonadotropin-releasing Hormone Stimulation Test for Precocious Puberty", Annals of Laboratory Medicine, 31(4), pp.244~249 (2011), 대한진단검사의학회
- Weise M, "Effects of estrogen on growth plate senescence and epiphyseal fusion", Proc Natl Acad Sci USA, 98, pp.6871~6876 (2001)
- Byers S, "Quantitative histomorphometric analysis of the human growth plate from birth to adolescence", Bone, 27, pp.495~501 (2000)
- Carel JC, "Precocious puberty and statural growth", Hum Reprod Update, 10, pp.135~147 (2004)
- Crowley WF Jr, "Therapeutic use of pituitary desensitization with a long-acting lhrh agonist: a potential new treatment for idiopathic precocious puberty", J Clin Endocrinol Metab, 52, pp.370~372 (1981)
- Attie KM, "The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency:evidence for a direct role of sex steroids", J Clin Endocrinol Metab, 71, pp.975~983 (1990)
- Cara JF, "Growth hormone deficiency impedes the rise in plasma insulin-like growth factor I levels associated with precocious puberty", J Pediatr, 115, pp.64~68 (1989)
- Partsch CJ, "Management and outcome of central precocious puberty", Clin Endocrinol, 56, pp.129~148 (2002)
- Adan L, "Factors predicting adult height in girls with idiopathic central precocious puberty: implications for treatment", Clin Endocrinol, 56, pp.297~302 (2002)
- Paul D, "Long-term effect of gonadotropin-releasing hormone agonist therapy on final and near-final height in 26 children with true precocious puberty treated at a median age of less than 5years", J Clin Endocrinol Metab, 80, pp.546~551 (1995)
- Allali S, "Predicting the adult height of girls with central precocious puberty", Med Sci Monit, 17, pp.PH41~PH48 (2011)
- Kauli R, "Final height of girls with central precocious puberty, untreated versus treated with cyproterone acetate or GnRH analogue. A comparative study with re-evaluation of predictions by the Bayley-Pinneau method", Horm Res, 47, pp.54~61 (1997)
- Oerter KE, "Adult height in precocious puberty after longterm treatment with deslorelin", J Clin Endocrinol Metab, 73, pp.1235~1240 (1991)
- Greulich WW, "Radiographic atlas of skeletal development of hand wrist" (1971), Stanford University Press
- Cole TJ, "The LMS method for constructing normalized growth standards", Eur J Clin Nutr, 44, pp.45~60 (1990)
- 2007 Korean children and adolescents growth standard (commentary for the development of 2007 growth chart), "Korea Centers for Disease Control and Prevention", Korea Centers for Disease Control and Prevention, ~ (2007)
- Hyun SE, "Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3in Korean children and adolescents", Clin Biochem, 45, pp.16~21 (2012)
- Harris DA, "Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist", J Clin Endocrinol Metab, 61, pp.152~159 (1985)
- DiMartino-Nardi J, "The effect of long-acting analog of luteinizing hormone-releasing hormone on growth hormone secretory dynamics in children with precocious puberty", J Clin Endocrinol Metab, 73, pp.902~906 (1991)
- 이경희, "성선자극호르몬방출호르몬 유도체 치료를 받는 진성성조숙증 여아의 1년간 IGF-1, IGFBP-3 혈중농도의 변화", Annals of Pediatirc Endocrinology & Metabolism, 16(1), pp.20~23 (2011), 대한소아내분비학회
- Kanety H, "Insulinlike growth factor-I and IGF binding protein-3 remain high after GnRH analogue therapy in girls with central precocious puberty", Clin Endocrinol, 45, pp.7~12 (1996)
- Sklar CA, "Suppression of the pituitary-gonadal axis in children with central precocious puberty: effects on growth, growth hormone, insulin-like growth factor-I, and prolactin secretion", J Clin Endocrinol Metab, 73, pp.734~738 (1991)
- Belgorosky A, "Serum IGF-I during treatment of three different types of abnormal puberty, possible role of IGF-I in pubertal maturation", Proceedings of the 76th Annual Meeting of the Endocrine Society (1994), The Endocrine Society
- Weise M, "Determinants of growth during gonadotropin-releasing hormone analog therapy for precocious puberty", J Clin Endocrinol Metab, 89, pp.103~107 (2004)
- 이승재, "Effects of Gonadotropin-Releasing Hormone Agonist Therapy on Body Mass Index and Height in Girls with Central Precocious Puberty", 전남의대학술지, 48(1), pp.27~31 (2012), 의과학연구소
- Bouvattier C, "Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized longterm pilot study", J Clin Endocrinol Metab, 84, pp.3575~3578 (1999)
- Cassio A, "Randomised trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7.5-8.5 years", Arch Dis Child, 81, pp.329~332 (1999)
- Badaru A, "Sequential comparisons of onemonth and three-month depot leuprolide regimens in central precocious puberty", J Clin Endocrinol Metab, 91, pp.1826~1867 (2006)
