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Relationship between serum insulin-like growth factor-1, IGF binding protein-3 levels and body height before and after gonadotropin-releasing hormone agonist therapy

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주제분류소아과학

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Purpose: The gonadotropin-releasing hormone agonist (GnRHa) is widely used to treat patients with precocious puberty. However, its effect on growth is often difficult to predict because of the diverse nature of its causes and presentation. This study aims to show the impact of GnRHa treatment on insulin-like growth factor-1 (IGF-I) and IGF binding protein-3 (IGFBP-3) secretion, growth, and on other parameters that may help estimate the height velocity. Methods: Data from 60 girls (mean age, 8.8±0.7 years) treated with GnRHa were analyzed. Their height, bone age (BA), serum IGF-I, and IGFBP-3 concentrations were measured at the start and after a year of GnRHa treatment. To eliminate the confounding effect of chronological age (CA), the standard deviation scores (SDSs) of their height, IGF-I, and IGFBP-3 concentrations according to their CA at the start and after a year of GnRHa treatment were calculated. We looked for possible correlations between these variables and compared the subgroups based on their height velocities and midparental heights. Results: During their one-year GnRHa therapy, height SDS for CA significantly decreased to 0.81±0.83 (P<0.001), but height SDS for BA increased to –0.28±0.68 (P<0.001). There was no significant change in serum IGF-I SDS, IGFBP-3 SDS, and IGF-I/IGFBP-3 ratio. The advanced BA was the factor most strongly correlated to the height velocity (R=0.265, P=0.041). Conclusion: These findings suggest that GnRHa treatment may affect the height velocity due to mechanisms other than suppression of the IGF-I and IGFBP-3 secretory axis.

Abstract

Purpose: The gonadotropin-releasing hormone agonist (GnRHa) is widely used to treat patients with precocious puberty. However, its effect on growth is often difficult to predict because of the diverse nature of its causes and presentation. This study aims to show the impact of GnRHa treatment on insulin-like growth factor-1 (IGF-I) and IGF binding protein-3 (IGFBP-3) secretion, growth, and on other parameters that may help estimate the height velocity. Methods: Data from 60 girls (mean age, 8.8±0.7 years) treated with GnRHa were analyzed. Their height, bone age (BA), serum IGF-I, and IGFBP-3 concentrations were measured at the start and after a year of GnRHa treatment. To eliminate the confounding effect of chronological age (CA), the standard deviation scores (SDSs) of their height, IGF-I, and IGFBP-3 concentrations according to their CA at the start and after a year of GnRHa treatment were calculated. We looked for possible correlations between these variables and compared the subgroups based on their height velocities and midparental heights. Results: During their one-year GnRHa therapy, height SDS for CA significantly decreased to 0.81±0.83 (P<0.001), but height SDS for BA increased to –0.28±0.68 (P<0.001). There was no significant change in serum IGF-I SDS, IGFBP-3 SDS, and IGF-I/IGFBP-3 ratio. The advanced BA was the factor most strongly correlated to the height velocity (R=0.265, P=0.041). Conclusion: These findings suggest that GnRHa treatment may affect the height velocity due to mechanisms other than suppression of the IGF-I and IGFBP-3 secretory axis.

참고문헌 (31)

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관련 논문AI추천

Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatmentHwang Il-Tae, Park Jun-Hong, Yang Seung대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2020 · 제25권 제4호Adult height in girls with central precocious puberty treated with gonadotropin-releasing hormone agonist with or without growth hormone권아름, 김덕희, 김호성, 송경철, 정모경, 채현욱대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2014 · 제19권 제4호Effect of gonadotropin-releasing hormone agonist treatment on near final height in girls with central precocious puberty and early pubertyChoi Soo-Han, Jo Ha Young, Kim Hye-Young, Kim Young Mi, Kwak Min Jung, Park Kyung Hee, Park Su Jeong, Yang Eun Hye, Yoo Hye Won대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2023 · 제28권 제1호Comparing adult height gain and menarcheal age between girls with central precocious puberty treated with gonadotropin-releasing hormone agonist alone and those treated with combined growth hormone therapyDong Hee Kang, Gwang Yeon Lee, Hyo Jung Koh, Min Sub Kim, Se Young Kim대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2019 · 제24권 제2호Effects of gonadotropin-releasing hormone agonist treatment on final adult height in boys with idiopathic central precocious pubertyCho Ah Young, Kim Eun Young, Ko Su Yeong, Lee Jae Hee대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2021 · 제26권 제4호성선자극호르몬방출호르몬 유도체 치료를 받는 진성성조숙증 여아의 1년간 IGF-1, IGFBP-3 혈중농도의 변화이경희대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2011 · 제16권 제1호

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