The effect of overweight on the luteinizing hormone level after gonadorelin stimulation test in girls with idiopathic central precocious puberty
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: We investigated the effect of overweight on luteinizing hormone (LH) levels after a gonadorelin stimulation test in Korean girls with idiopathic central precocious puberty (CPP). Methods: Medical records of 234 girls diagnosed with idiopathic CPP were reviewed retrospectively. CPP was diagnosed when the peak LH levels after gonadorelin stimulation was >5.0 U/L. The enrolled girls had a peak LH level >5.0 U/L after a gonadorelin stimulation test. Selected girls were classified as normoweight (body mass index [BMI] below the 85th percentile with respect to age) and overweight (BMI greater than the 85th percentile with respect to age). Results: The peak LH (8.95±2.85 U/L vs. 11.97±8.42 U/L, P<0.01) and peak folliclestimulating hormone (9.60±2.91 U/L vs. 11.17±7.77 U/L, P=0.04) after gonadorelin stimulation were lower in overweight girls with idiopathic CPP than in normoweight girls with idiopathic CPP. Being overweight was negatively associated with peak LH levels after gonadorelin stimulation test (odds ratio, 0.89; 95 % confidence interval, 0.81–0.98, P=0.02). Conclusion: In girls with idiopathic CPP, being overweight led to a lower LH peak after gonadorelin stimulation. Further research is needed to better understand the role of overweight on gonadotropin secretion in precocious puberty.
Abstract
Purpose: We investigated the effect of overweight on luteinizing hormone (LH) levels after a gonadorelin stimulation test in Korean girls with idiopathic central precocious puberty (CPP). Methods: Medical records of 234 girls diagnosed with idiopathic CPP were reviewed retrospectively. CPP was diagnosed when the peak LH levels after gonadorelin stimulation was >5.0 U/L. The enrolled girls had a peak LH level >5.0 U/L after a gonadorelin stimulation test. Selected girls were classified as normoweight (body mass index [BMI] below the 85th percentile with respect to age) and overweight (BMI greater than the 85th percentile with respect to age). Results: The peak LH (8.95±2.85 U/L vs. 11.97±8.42 U/L, P<0.01) and peak folliclestimulating hormone (9.60±2.91 U/L vs. 11.17±7.77 U/L, P=0.04) after gonadorelin stimulation were lower in overweight girls with idiopathic CPP than in normoweight girls with idiopathic CPP. Being overweight was negatively associated with peak LH levels after gonadorelin stimulation test (odds ratio, 0.89; 95 % confidence interval, 0.81–0.98, P=0.02). Conclusion: In girls with idiopathic CPP, being overweight led to a lower LH peak after gonadorelin stimulation. Further research is needed to better understand the role of overweight on gonadotropin secretion in precocious puberty.
참고문헌 (20)
- Carel JC, "Clinical practice. Precocious puberty", N Engl J Med, 358, pp.2366~2377 (2008)
- Lee HS, "Luteinizing hormone secretion during gonadotropin-releasing hormone stimulation tests in obese girls with central precocious puberty", J Clin Res Pediatr Endocrinol, 8, pp.392~398 (2016)
- Wang Y, "Worldwide trends in childhood overweight and obesity", Int J Pediatr Obes, 1, pp.11~25 (2006)
- Burt Solorzano CM, "Obesity and the pubertal transition in girls and boys", Reproduction, 140, pp.399~410 (2010)
- Barber TM, "Obesity and polycystic ovary syndrome", Clin Endocrinol (Oxf ), 65, pp.137~145 (2006)
- Poretsky L., "Commentary: Polycystic ovary syndrome--increased or preserved ovarian sensitivity to insulin?", J Clin Endocrinol Metab, 91, pp.2859~2860 (2006)
- 문진수, "2007 한국 소아 청소년 성장도표 : 개발 과정과 전망", Clinical and Experimental Pediatrics, 51(1), pp.1~25 (2008), 대한소아청소년과학회
- Greulich WW, "Radiologic atlas of skeletal development of the hand and wrist" (1959), Standford University
- 서정환, "Factors that predict a positive response on gonadotropin-releasing hormone stimulation test for diagnosing central precocious puberty in girls", Annals of Pediatric Endocrinology & Metabolism, 18(4), pp.202~207 (2013), 대한소아내분비학회
- Pagán YL, "Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome:investigation of hypothalamic and pituitary contributions", J Clin Endocrinol Metab, 91, pp.1309~1316 (2006)
- Roth LW, "Evidence of GnRH antagonist escape in obese women", J Clin Endocrinol Metab, 99, pp.E871~875 (2014)
- Sliwowska JH, "Insulin: its role in the central control of reproduction", Physiol Behav, 133, pp.197~206 (2014)
- Kavanagh K, "Liver fat and SHBG affect insulin resistance in midlife women: the Study of Women's Health Across the Nation (SWAN)", Obesity (Silver Spring), 21, pp.1031~1038 (2013)
- Pinkney J, "Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)", J Clin Endocrinol Metab, 99, pp.3224~3232 (2014)
- Pauli EM, "Diminished paternity and gonadal function with increasing obesity in men", Fertil Steril, 90, pp.346~351 (2008)
- Pilia S, "The effect of puberty on insulin resistance in obese children", J Endocrinol Invest, 32, pp.401~405 (2009)
- Baratta M., "Leptin--from a signal of adiposity to a hormonal mediator in peripheral tissues", Med Sci Monit, 8, pp.RA282~RA292 (2002)
- Friedman JM, "Leptin and the regulation of body weight in mammals", Nature, 395, pp.763~770 (1998)
- Soliman AT, "Leptin in pediatrics: a hormone from adipocyte that wheels several functions in children", Indian J Endocrinol Metab, 16(Suppl 3), pp.S577~S587 (2012)
- Pan H, "Advances in understanding the interrelations between leptin resistance and obesity", Physiol Behav, 130, pp.157~169 (2014)