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Low bone mineral density in children and adolescents with cancer

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주제분류소아과학

초록

Maximizing accumulation of bone mass during childhood and adolescence is essential to attaining optimal peak bone mass. Childhood cancer survivors (CCS) have lower bone mineral density (BMD) than the general population. Chemotherapeutic agents including steroids and radiotherapy can affect BMD. Cancer itself, hormonal insufficiency, a poor nutritional state, and a deficit of physical activities during or after treatment also influence BMD in CCS, resulting in failure to achieve appropriate peak bone mass. Low BMD in childhood and adolescence can lead to osteoporosis in adult life and complications such as bone pain, bone deformity, and fractures. Thus, BMD in CCS should be monitored with appropriate intervention. Adequate intake of calcium and vitamin D and an increase in physical activity are recommended. Timely supplements of hormones are needed in some cases. Some publications have reported that bisphosphonate therapies using pamidronate or alendronate were well tolerated in CCS and helped increase BMD.

Abstract

Maximizing accumulation of bone mass during childhood and adolescence is essential to attaining optimal peak bone mass. Childhood cancer survivors (CCS) have lower bone mineral density (BMD) than the general population. Chemotherapeutic agents including steroids and radiotherapy can affect BMD. Cancer itself, hormonal insufficiency, a poor nutritional state, and a deficit of physical activities during or after treatment also influence BMD in CCS, resulting in failure to achieve appropriate peak bone mass. Low BMD in childhood and adolescence can lead to osteoporosis in adult life and complications such as bone pain, bone deformity, and fractures. Thus, BMD in CCS should be monitored with appropriate intervention. Adequate intake of calcium and vitamin D and an increase in physical activity are recommended. Timely supplements of hormones are needed in some cases. Some publications have reported that bisphosphonate therapies using pamidronate or alendronate were well tolerated in CCS and helped increase BMD.

참고문헌 (61)

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관련 논문AI추천

Bone morbidity in pediatric acute lymphoblastic leukemia안문배, Byung-Kyu Suh대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2020 · 제25권 제1호Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma김동호, Ju-Hee Seo, Ju Hyun Ahn, Jun Ah Lee, Jung Sub Lim, Wan Hyeong Cho대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2015 · 제20권 제3호Efficacy of pamidronate in pediatric osteosarcoma patients with low bone mineral density김동호, Aery Choi, Ju-Hee Seo, Ju Hyun Ahn, Jun Ah Lee, Jung Sub Lim, Se Won Lim, Wan Hyeong Cho대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2016 · 제21권 제1호Bone modeling, remodeling, and skeletal health in children and adolescents: mineral accrual, assessment and treatmentChiara Maggioli, Stefano Stagi대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2017 · 제22권 제1호소아청소년기 항암치료 후 최대 골량 형성 부전으로 저충격 골절을 보인 20대 여성김동호, 김동환, 김승연, 이준아, 이현정, 임중섭, 조중범대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2010 · 제15권 제3호Factors affecting bone mineral density in children and adolescents with secondary osteoporosis이재욱, Ahn Moon Bae, Cho Bin, Chung Nack-Gyun, Jang Min Jeong, Jung Min Ho, Kim Seongkoo, Shin Chungwoo, Suh Byung-Kyu대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2023 · 제28권 제1호

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