성장호르몬 치료 환아에서 발생한 대퇴골두골단분리증 2례
Two Cases of Slipped Capital Femoral Epiphysis in Children Receiving Growth Hormone Therapy
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
대퇴골두골단분리증은 주로 청소년기에 발병하는 드문 질환으로 비만, 외상, 성발육 지연, 골성숙 지연, 내분비 질환, 만성 신부전, 유전자 질환, 성장호르몬 치료 그리고 GnRH agonist치료 등과 관련이 있는 것으로 알려져 있다. 이에 저자들은 성장호르몬 치료를 받은 환아 중 2례의 대퇴골두골단분리증을 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
Abstract
Slipped capital femoral epiphysis is a rare hip disorder that mainly occurs in pubertal children. Although the exact cause of this disorder is unknown, it is known to be associated with obesity, trauma, delayed sexual development, delayed bone maturation, chronic renal failure, genetic diseases, endocrine disorders (growth hormone deficiency, hypothyroidism, hypogonadism), growth hormone therapy, and gonadotropin releasing hormone agonist (GnRH agonist) therapy. We report 2 cases of slipped capital femoral epiphysis in adolescent females who were receiving growth hormone therapy. The first case is of a 16 year-old-girl with chronic renal failure and renal osteodystrophy. The second case is of an 11 year-old-girl with idiopathic precocious puberty who had received GnRH agonist and growth hormone therapy. Unilateral or bilateral slipped capital femoral epiphysis developed at 1 year 3 months after treatment in both the cases. The chief complaints were pain in the hip joint and lower extremities. Growth hormone and/or GnRH agonist therapy was stopped, and in situ screw fixations of the involved hip epiphyses were performed.
참고문헌 (20)
- Tachdjian MO, "Slipped capital femoral epiphysis. In: Pediatric Orthopedics 2nd ed", pp.1016~1081 (1990), WB Saunders Co
- Kim JE, "A case of slipped capital epiphysis developed during growth hormone treatment", Korean J Med, 60, pp.589~592 (2001)
- Kempers MJ, "Can GnRH- agonist treatment cause slipped capital femoral epiphysis?", J Pediatr Endocrinol Metab, 14, pp.729~734 (2001)
- Fine RN, "Growth hormone treatment of children with chronic renal insufficiency, end-stage renal disease and following renal transplantation-update 1997", J Pediatr Endocrinol Metab, 10, pp.361~370 (1997)
- Wells D, "Review of slipped capital femoral epiphysis associated with endocrine disease", J Pediatr Orthop, 13, pp.610~614 (1993)
- Nabhan ZM, "Monozygotic twins with Turner syndrome develop slipped capital femoral epiphysis on growth hormone therapy", Pediatrics, 118, pp.e1900~e1903 (2006)
- Blethen SL, "Slipped capital femoral epiphysis in children treated with growth hormone. A summary of the National Cooperative Growth Study experience", Horm Res, 46, pp.113~116 (1996)
- Howorth B, "Slipping of the capital femoral epiphysis. Etiology", Clin Orthop Relat Res, 48, pp.49~52 (1966)
- Harris WR, "The endocrine basis for slipping of the upper femoral epiphysis: an experimental study", J Bone Joint Surg, 32B, pp.5~11 (1950)
- Semple JC, "Epiphyseal maturation and slipping femoral epiphysis in a hypopituitary dwarf", Orthopaedics, 2, pp.31~42 (1969)
- Kelsey JL, "The incidence and distribution of slipped capital femoral epiphysis in Connecticut and Southwestern United States", J Bone Joint Surg, 52, pp.1203~1216 (1970)
- Lewinson D, "Effect of thyroid hormone and growth hormone on recovery from hypothyroidism of epiphyseal growth plate cartilage and its adjacent bone", Endocrinology, 124, pp.937~945 (1989)
- Puri R, "Slipped upper femoral epiphysis and primary juvenile hypothyroidism", J Bone Joint Surg Br, 67, pp.14~20 (1985)
- Brenkel IJ, "Thyroid hormone levels in patients with slipped capital femoral epiphysis", J Pediatr Orthop, 8, pp.22~25 (1988)
- Wilcox PG, "Maturation factors in slipped capital femoral epiphysis", J Pediatr Orthop, 8, pp.196~200 (1988)
- Papavasiliou KA, "Potential influence of hormones in the development of slipped capital femoral epiphysis: a preliminary study", J Pediatr Orthop B, 16, pp.1~5 (2007)
- Rappaport EB, "Effects of exogenous growth hormone on growth plate cartilage in rats", Am J Dis Child, 141, pp.497~501 (1987)
- Loder RT, "Slipped capital femoral epiphysis associated with endocrine disorders", J Pediatr Orthop, 15, pp.349~356 (1995)
- Rappaport EB, "Slipped capital femoral epiphysis in growth hormone-deficient patients", Am J Dis Child, 139, pp.396~399 (1985)
- Loder RT, "capital femoral epiphysis associated with renal failure osteodystrophy", J Pediatr Orthop, 17, pp.205~211 (1997)