미숙아와 아픈 신생아에서 발생하는 내분비 질환
Endocrine Disorders in the Sick and Preterm Newborn
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Endocrine disorders develop commonly in preterm neonates and critically ill neonates. Preterm newborns have immature endocrine system as well as immature organs. Their adaptation to extrauterine life might be more challenging and more unfavorable. The most common endocrine disorders in the sick and preterm newborn are thyroid disorders, hypocalcemia, adrenal insufficiency and disorders of glucose metabolism. To detect the endocrine problems appropriately and to find best approaches to them, pediatric neonatologists and endocrinologists should be well aware of the epidemiology, pathophysiology, clinical characteristics and effective management of common endocrine disorders in the sick and preterm newborns. (J Korean Soc Pediatr Endocrinol 2011;16:73-79)
Abstract
Endocrine disorders develop commonly in preterm neonates and critically ill neonates. Preterm newborns have immature endocrine system as well as immature organs. Their adaptation to extrauterine life might be more challenging and more unfavorable. The most common endocrine disorders in the sick and preterm newborn are thyroid disorders, hypocalcemia, adrenal insufficiency and disorders of glucose metabolism. To detect the endocrine problems appropriately and to find best approaches to them, pediatric neonatologists and endocrinologists should be well aware of the epidemiology, pathophysiology, clinical characteristics and effective management of common endocrine disorders in the sick and preterm newborns. (J Korean Soc Pediatr Endocrinol 2011;16:73-79)
참고문헌 (55)
- Hyman SJ, "Perinatal endocrinology: Common endocrine disorders in the sick and premature newborn", Endocr Metab Clin N Am, 38, pp.509~524 (2009)
- van Iijn DA, "Neonatal detection of congenital hypothyroidism of central origin", J Clin Endocrinol Metab, 90, pp.3350~3359 (2005)
- Ogilvy-Stuart AL, "Neonatal thyroid disorders", Arch Dis Child Fetal Neonatal Ed, 87, pp.F165~F171 (2002)
- Kratzsch J, "Thyroid gland development and defects", Best Pract Clin Endocrinol Metab, 22, pp.57~75 (2008)
- Rapaport R, "Hypothyroxinemia in the preterm infans: the benefits and risks of thyrxine treatment", J Pediatr, 139, pp.182~188 (2001)
- Cuestas RA, "Thyroid function in healthy premature infants", J Pediatr, 92, pp.963~967 (1978)
- van Wassenaer AG, "Hypothryxinaemia and thyroid fuction after preterm birth", Semin Neonatol, 9, pp.3~11 (2004)
- Mercado M, "Thyroid function in very preterm infants", Early Hum Dev, 16, pp.131~141 (1988)
- Williams FLR, "Transient hypothyroxinaemia in preterm infants", Early Hum Dev, 82, pp.797~802 (2006)
- Uhrmann S, "Frequency of transient hypothyroxinaemia in low birthweight infants. Potential pitfall for neonatal screening programmes", Arch Dis Child, 56, pp.214~217 (1981)
- Osborn DA, "Thyroid hormone for preventing of neurodevelopmental impairment in preterm infants", Cochrane Database Syst Rev, (2), pp.CD001070~ (2000)
- Vanhole C, "L-thyroxine treatment of preterm newborns: clinical and endocrine effects", Pediatr Res, 42, pp.87~92 (1997)
- Smerdely P, "Topical iodine-containing antiseptics and neonatal hypothyroidism in very low birth weight infants", Lancet, 2, pp.661~664 (1989)
- Hyman SJ, "Late rise of thyroid stimulating hormone in ill newborns", J Pediatr Endocrinol Metab, 20, pp.501~510 (2007)
- Larson C, "Risk factors associated with delayed thyrotropin elevations in congenital hypothyroidism", J Pediatr, 143, pp.587~591 (2003)
- Hsu SC, "Perinatal calcium metabolism: physiology and pathophysiology", Semin Neonatol, 9, pp.23~36 (2004)
- Tsang RC, "Neonatal hypocalcemia in low birth weight infants", Pediatrics, 45, pp.773~781 (1970)
- Roberton NR, "Early neonatal hypocalcemia", Arch Dis Child, 50, pp.604~609 (1975)
- Root AW, "Disorders of mineral homeostasis in the neonate and infant, In Pediatric endocrinology. 3rd edition", pp.691~706 (2008), Saunders Elsevier
- Driscoll DA, "A genetic etiology for DiGeorge syndrome: consistent deletion and microdeletion of 22q11", Am J Hum Genet, 50, pp.924~933 (1992)
- Greig F, "Transient congenital hypoparathyrodism: resolution and recurrence in chromosome 22q11 deletion", J Pediatr, 128, pp.563~567 (1996)
- Watterberg KL, "Adrenocortical function and dysfunction in the fetus and neonate", Semin Neonatol, 9, pp.13~21 (2004)
- Pepe GJ, "Actions of placental and fetal adrenal steroid hormones in primate pregnancy", Endocr Rev, 16, pp.608~648 (1995)
- Mediano S, "Developmental and functional biology of the primate fetal adrenal cortex", Endocr Rev, 18, pp.378~403 (1997)
- Parker CR Jr, "Immunohistochemical evaluation of the cellular localization and ontogeny of 3 beta-hydroxystreoid dehydrogenase-delta 5-4 isomerase in the human fetal adrenal gland", Endocr Res, 21, pp.69~80 (1995)
- Ng PC, "Reference ranges and factors affecting the human corticotropin-releasing hormone test in preterm, very low birth weight infants", J Clin Endocrinol Metab, 87, pp.4621~4628 (2002)
- Al Saedi S, "Reference ranges for serum cortisol and 17-OH-progesterone levels in preterm infants", J Pediatr, 126, pp.985~987 (1995)
- Heckann M, "Reference range for serum cortisol in well preterm infants", Arch Dis Child Fetal Neonatal Ed, 71, pp.F171~F174 (1999)
- Ng PC, "Is there a normal range of serum cortisol concentration for preterm infants", Pediatrics, 122, pp.873~875 (2008)
- Arnold J, "Longitudinal study of plasma cortisol and 17-hydroxyprogesterone in very low birth weight infants during the first 16 weeks of life", Biol Neonate, 72, pp.148~155 (1997)
- Ng PC, "Transient adrenocortical insufficiency of prematurity and systemic hypotension in very low birth weight infants", Arch Dis Child Fetal Neonatal Ed, 89, pp.F119~F126 (2004)
- Karlsson R, "Timing of peak serum cortisol values in preterm infants in low-dose and the standard ACTH tests", Pediatr Res, 45, pp.367~369 (1999)
- Bolt RJ, "Fetal growth and the function of the adrenal cortex in preterm infants", J Clin Endocrinol Metab, 87, pp.1194~1199 (2002)
- Ng PC, "A double-blind, randomized, controlled study of a stress dose hydrocortisone for rescue treatment of refractory hypotension in infants", Pediatrics, 117, pp.367~375 (2006)
- Aucott SW, "PROPHET Study Group. Do cortisol concentrations predict short- term outcomes in extremely low birth weight infants", Pediatrics, 122, pp.775~781 (2008)
- Watterberg KL, "Evidence of early adrenal insufficiency in babies who develop bronchopulmonary dysplasia", Pediatrics, 85, pp.120~125 (1995)
- Watterberg KL, "Chorioamnionitis and early lung inflammation in babies who develop bronchopulmonary dysplasia", Pediatrics, 97, pp.210~215 (1996)
- Watterberg KL, "Prophylaxis against early adrenal insufficiency to prevent chronic lung disease in premature infants", Pediatrics, 104, pp.1258~1263 (1999)
- Watterberg KL, "Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial", Pediatrics, 114, pp.1649~1657 (2004)
- Langdon DR, "Hypoglycemia in the infant and child, In Pediatric endocrinology. 3rd edition", pp.422~423 (2008), Saunders Elsevier
- Sunehag AL, "Glucose extremes in newborn infants", Clin Perinataol, 29, pp.245~260 (2002)
- Mitanchez D, "Glucose regulation in preterm newborn infants", Horm Res, 68, pp.265~271 (2007)
- Hume R, "Glucose homeostasis in the newborn", Early Hum Dev, 81, pp.95~101 (2005)
- Hawdon JM, "Hypoglycemia and the neonatal brain", Eur J Pediatr, 158(1), pp.S9~S12 (1999)
- Stanley CA, "Hyperinsulinism in infants and children", Pediatr Clin North Am, 44, pp.363~374 (1997)
- Hays SP, "Hyperglycemia is a risk factor for early death and morbidity in extremely low birth- weight infants", Pediatrics, 118, pp.1811~1818 (2006)
- Beardsall K, "A randomized controlled trial of early insulin therapy in very low birth weight infants, "NIRTURE" (neonatal insulin replacement therapy in Europe)", BMC Pediatr, 7, pp.29~39 (2007)
- Kairamknonda VR, "Controversies in the management of hyperglycemia in the ELBW infant", Indian Pediatr, 45, pp.29~38 (2008)
- Garg R, "Hyperglycemia and retinopathy of prematurity in very low birth weight infants", J Perinatol, 23, pp.186~194 (2003)
- van Kempen AAMW, "Stimulation of gluconeogenesis by intravenous lipids in preterm infants: response depends on fatty acid profile", Am J Physiol Endocrinol Metab, 290, pp.e723~e730 (2006)
- Berseth CL, "Effect of early feeding on maturation of the preterm infant's small intestine", J Pediatr, 120, pp.947~953 (1992)
- Mena P, "Insulin homeostasis in the extremely low birth weight infant", Semin Perinatol, 25, pp.436~446 (2001)
- Shield JP, "Aetiopathology and genetic basis of neonatal diabetes", Arch Dis Fetal Neonatal Ed, 76, pp.F39~F42 (1997)
- Shield JP, "Is transient neonatal diabetes a risk factor for diabetes later in life", Lancet, 341, pp.693~ (1993)
- Shield JP, "Neonatal diabetes: new insight into etiology and implications", Horm Res, 53(1), pp.7~11 (2000)
