에스트로겐 수용체의 조직특이성 결손이 있는 암컷마우스의 성장과 사춘기 발달
The Growth and Pubertal Development in Female Mice with Tissue-specific Knock out of Estrogen Receptor
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The roles of estrogen and its receptors are important for control of puberty, pubertal growth spurt, epiphyseal fusion of long bone, and accretion of bone mineral content in adolescent. But, the mechanism of functions of them is not fully understood. The female mice with tissue-specific knock out (KO) of estrogen receptor (ER) were generated to determine the roles of them in the growth and reproductive axis. The serum levels of growth hormone (GH) were decreased but the body lengths were not in somatotrope-specific ERα KO mice compared with wild ones. The onset of puberty was delayed in gonadotropin releasing hormone (GnRH) neuron -specific ERα KO mice. The reproductive axis was disturbed in gonadotrope-specific ERα KO mice. Additional studies are required to evaluate the various roles of estrogen and its receptors in growth and pubertal development. Future works will focus on the phenomes of tissue-specific KO of ERβ or aromatase in mice, other animal models, and in vitro or vivo studies of ER agonists or antagonists. (J Korean Soc Pediatr Endocrinol 2011;16:67-72)
Abstract
The roles of estrogen and its receptors are important for control of puberty, pubertal growth spurt, epiphyseal fusion of long bone, and accretion of bone mineral content in adolescent. But, the mechanism of functions of them is not fully understood. The female mice with tissue-specific knock out (KO) of estrogen receptor (ER) were generated to determine the roles of them in the growth and reproductive axis. The serum levels of growth hormone (GH) were decreased but the body lengths were not in somatotrope-specific ERα KO mice compared with wild ones. The onset of puberty was delayed in gonadotropin releasing hormone (GnRH) neuron -specific ERα KO mice. The reproductive axis was disturbed in gonadotrope-specific ERα KO mice. Additional studies are required to evaluate the various roles of estrogen and its receptors in growth and pubertal development. Future works will focus on the phenomes of tissue-specific KO of ERβ or aromatase in mice, other animal models, and in vitro or vivo studies of ER agonists or antagonists. (J Korean Soc Pediatr Endocrinol 2011;16:67-72)
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