Incidence trends and associated factors of diabetes mellitus in Korean children and adolescents: a retrospective cohort study in Busan and Gyeongnam
2
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
Purpose: This study investigated the incidence trends and associated factors of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in children and adolescents under 15 years of age in Busan and Gyeongnam, Korea from 2001 to 2010. Methods: Medical records of newly diagnosed diabetes patients (n=328; 160 males, 168 females) were collected in questionnaire form from 5 tertiary and 42 general hospitals in Busan and Gyeongnam. Results: The average crude incidence rate of T1DM and T2DM was 2.01/100,000 (95% confidence interval [CI], 1.76–2.28) and 0.75/100,000 (95% CI, 0.60–0.92), respectively. The incidence rate ratio (IRR) of T1DM was 1.31 (95% CI, 1.01–1.69), and that of T2DM was 1.97 (95% CI, 1.25–3.11) in the latter half-decade (2006 to 2010) compared to the early half-decade (2001 to 2005). There were gradually increasing incidence trends in both T1DM and T2DM over the 10-year period (P for trend: T1DM, 0.0009; T2DM, <0.0001). Age-specific IRR was highest in the 10- to 14-yearold group, regardless of diabetes type. In particular, a rapid increase in incidence of T2DM occurred in the 10- to 14-year-old group. IRR for females was 1.07 (95% CI, 0.83–1.38) for T1DM and 1.56 (95% CI, 1.01–2.41) for T2DM. IRR for Busan (urban) was 1.41 (95% CI, 1.09–1.83) for T1DM and 1.49 (95% CI, 0.96–2.30) for T2DM. Conclusion: T1DM and T2DM incidence both increased over time in youth under age 15 living in Busan and Gyeongnam; in particular, the incidence of T2DM in adolescents increased more rapidly.
Abstract
Purpose: This study investigated the incidence trends and associated factors of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in children and adolescents under 15 years of age in Busan and Gyeongnam, Korea from 2001 to 2010. Methods: Medical records of newly diagnosed diabetes patients (n=328; 160 males, 168 females) were collected in questionnaire form from 5 tertiary and 42 general hospitals in Busan and Gyeongnam. Results: The average crude incidence rate of T1DM and T2DM was 2.01/100,000 (95% confidence interval [CI], 1.76–2.28) and 0.75/100,000 (95% CI, 0.60–0.92), respectively. The incidence rate ratio (IRR) of T1DM was 1.31 (95% CI, 1.01–1.69), and that of T2DM was 1.97 (95% CI, 1.25–3.11) in the latter half-decade (2006 to 2010) compared to the early half-decade (2001 to 2005). There were gradually increasing incidence trends in both T1DM and T2DM over the 10-year period (P for trend: T1DM, 0.0009; T2DM, <0.0001). Age-specific IRR was highest in the 10- to 14-yearold group, regardless of diabetes type. In particular, a rapid increase in incidence of T2DM occurred in the 10- to 14-year-old group. IRR for females was 1.07 (95% CI, 0.83–1.38) for T1DM and 1.56 (95% CI, 1.01–2.41) for T2DM. IRR for Busan (urban) was 1.41 (95% CI, 1.09–1.83) for T1DM and 1.49 (95% CI, 0.96–2.30) for T2DM. Conclusion: T1DM and T2DM incidence both increased over time in youth under age 15 living in Busan and Gyeongnam; in particular, the incidence of T2DM in adolescents increased more rapidly.
참고문헌 (23)
- Korean Society of Pediatric Endocrinology, "Pediatric endocrinology" (2004), Kwang Moon Publishing Co
- Fagot-Campagna A, "Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective", J Pediatr, 136, pp.664~672 (2000)
- SEARCH for Diabetes in Youth Study Group, "The burden of diabetes mellitus among US youth:prevalence estimates from the SEARCH for Diabetes in Youth Study", Pediatrics, 118, pp.1510~1518 (2006)
- DIAMOND Project Group, "Incidence and trends of childhood type 1 diabetes worldwide 1990-1999", Diabet Med, 23, pp.857~866 (2006)
- Writing Group for the SEARCH for Diabetes in Youth Study Group, "Incidence of diabetes in youth in the United States", JAMA, 297, pp.2716~2724 (2007)
- Zhang H, "Increasing incidence of type 1 diabetes in children aged 0-14years in Harbin, China (1990-2000)", Prim Care Diabetes, 2, pp.121~126 (2008)
- Kitagawa T, "Increased incidence of non-insulin dependent diabetes mellitus among Japanese schoolchildren correlates with an increased intake of animal protein and fat", Clin Pediatr (Phila), 37, pp.111~115 (1998)
- Pinhas-Hamiel O, "The global spread of type 2diabetes mellitus in children and adolescents", J Pediatr, 146, pp.693~700 (2005)
- 고승현, "Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus in Korea", Diabetes and Metabolism Journal, 36(1), pp.6~12 (2012), 대한당뇨병학회
- 이병두, "한국인 당뇨병의 역학적 특성", Diabetes and Metabolism Journal, 27(3), pp.173~178 (2003), 대한당뇨병학회
- The Committee for Public Health Statistics, "Incidence of type 1 diabetes mellitus in Korea 1995-2000", Program and abstract, the 51st Annual Fall Meeting of Korean Pediatric Society (2001), The Korean Pediatric Society
- American Diabetes Association, "Diagnosis and classification of diabetes mellitus", Diabetes Care, 33(Suppl 1), pp.S62~S69 (2010)
- "Statistics of residence registration population" (2012)[URL]
- Maahs DM, "Epidemiology of type 1 diabetes", Endocrinol Metab Clin North Am, 39, pp.481~497 (2010)
- Urakami T, "Urine glucose screening program at schools in Japan to detect children with diabetes and its outcomeincidence and clinical characteristics of childhood type 2diabetes in Japan", Pediatr Res, 61, pp.141~145 (2007)
- 박지민, "소아연령에서의 2형 당뇨병의 임상적 고찰", Korean Journal of Pediatrics, 45(5), pp.13~653 (2002), 대한소아과학회
- 윤경아, "소아 청소년기에 발생한 2형 당뇨병의 임상적 경과", Annals of Pediatirc Endocrinology & Metabolism, 14(1), pp.19~24 (2009), 대한소아내분비학회
- Barker DJ, "Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth", Diabetologia, 36, pp.62~67 (1993)
- Mericq V., "Prematurity and insulin sensitivity", Horm Res, 65(Suppl 3), pp.131~136 (2006)
- 홍은희, "2001-2008년 진단된 소아당뇨병의 분포와 특징", Annals of Pediatirc Endocrinology & Metabolism, 14(2), pp.110~115 (2009), 대한소아내분비학회
- Pundziute-Lycka A, "The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998", Diabetologia, 45, pp.783~791 (2002)
- Pinhas-Hamiel O, "Increased incidence of non-insulindependent diabetes mellitus among adolescents", J Pediatr, 128(5 Pt 1), pp.608~615 (1996)
- 이혜영, "Type 2 Diabetes in Urban and Rural Districts in Korea: Factors Associated with Prevalence Difference", Journal of Korean Medical Science, 25(12), pp.1777~1783 (2010), 대한의학회