A successful treatment of hypercalcemia with zoledronic acid in a 15-year-old boy with acute lymphoblastic leukemia
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Severe hypercalcemia in children is a rare medical emergency. We present a case of a 15-year-old boy with hypercalcemia (total calcium level, 14.2 mg/dL) with a normal complete blood count, no circulating blasts in the peripheral blood film, and no other signs of acute lymphoblastic leukemia (ALL), including no signs of lymphadenopathy or hepatosplenomegaly. The hypercalcemia was successfully treated with zoledronic acid. As hypercalcemia can be the only presenting symptom of ALL in children, the diagnosis is often delayed. In children presenting with hypercalcemia, malignancies must be considered in the differential diagnosis.
Abstract
Severe hypercalcemia in children is a rare medical emergency. We present a case of a 15-year-old boy with hypercalcemia (total calcium level, 14.2 mg/dL) with a normal complete blood count, no circulating blasts in the peripheral blood film, and no other signs of acute lymphoblastic leukemia (ALL), including no signs of lymphadenopathy or hepatosplenomegaly. The hypercalcemia was successfully treated with zoledronic acid. As hypercalcemia can be the only presenting symptom of ALL in children, the diagnosis is often delayed. In children presenting with hypercalcemia, malignancies must be considered in the differential diagnosis.
참고문헌 (19)
- Davies JH, "Investigation and management of hypercalcaemia in children", Arch Dis Child, 97, pp.533~538 (2012)
- Lietman SA, "Hypercalcemia in children and adolescents", Curr Opin Pediatr, 22, pp.508~515 (2010)
- McKay C, "Hypercalcemia complicating childhood malignancies", Cancer, 72, pp.256~260 (1993)
- Kerdudo C, "Hypercalcemia and childhood cancer: a 7-year experience", J Pediatr Hematol Oncol, 27, pp.23~27 (2005)
- Trehan A, "Hypercalcemia in acute lymphoblastic leukemia: an overview", J Pediatr Hematol Oncol, 31, pp.424~427 (2009)
- Hibi S, "Hypercalcemia in children presenting with acute lymphoblastic leukemia", Int J Hematol, 66, pp.353~357 (1997)
- Inukai T, "Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormonerelated peptide and E2A-HLF from translocation 17;19", Leukemia, 21, pp.288~ (2007)
- Eastell R, "Diagnosis of asymptomatic primary hyperparathyroidism:proceedings of the Fourth International Workshop", J Clin Endocrinol Metab, 99, pp.3570~3579 (2014)
- Mirrakhimov AE, "Hypercalcemia of malignancy: an update on pathogenesis and management", N Am J Med Sci, 7, pp.483~493 (2015)
- Wysolmerski JJ, "Parathyroid hormone-related protein: an update", J Clin Endocrinol Metab, 97, pp.2947~2956 (2012)
- Sternlicht H, "Hypercalcemia of malignancy and new treatment options", Ther Clin Risk Manag, 11, pp.1779~1788 (2015)
- Niizuma H, "PTHrP-independent hypercalcemia with increased proinflammatory cytokines and bone resorption in two children with CD19-negative precursor B acute lymphoblastic leukemia", Pediatr Blood Cancer, 49, pp.990~993 (2007)
- 이영호, "혈장프로스타글란딘 E2 농도의 증가와 함께 고칼슘혈증과 심한 골용해성 병변을 동반한 소아급성림프모구백혈병 1예", Blood Research, 42(4), pp.20~20 (2007), 대한혈액학회
- Sargent JT, "Haematological emergencies managing hypercalcaemia in adults and children with haematological disorders", Br J Haematol, 149, pp.465~477 (2010)
- Baroncelli GI, "The use of bisphosphonates in pediatrics", Horm Res Paediatr, 82, pp.290~302 (2014)
- George S, "Short-term safety of zoledronic acid in young patients with bone disorders: an extensive institutional experience", J Clin Endocrinol Metab, 100, pp.4163~4171 (2015)
- Kolyva S, "Hypercalcemia and osteolytic lesions as presenting symptoms of acute lymphoblastic leukemia in childhood. The use of zoledronic acid and review of the literature", J Pediatr Endocrinol Metab, 27, pp.349~354 (2014)
- Lokadasan R, "Hypercalcaemia with disseminated osteolytic lesions: a rare presentation of childhood acute lymphoblastic leukaemia", Ecancermedicalscience, 9, pp.542~ (2015)
- Martins AL, "Severe hypercalcemia as a form of acute lymphoblastic leukemia presentation in children", Rev Bras Ter Intensiva, 27, pp.402~405 (2015)