Insulin resistance and bone age advancement in girls with central precocious puberty
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Purpose: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study was to determine whether insulin resistance is associated with bone age (BA) advancement in girls with CPP. Methods: We retrospectively analyzed the records of 804 girls referred for puberty evaluation. Anthropometric measurements, BA, sex hormone, sex hormone binding globulin (SHBG), and insulin levels, lipid profiles, and gonadotropin releasing hormone stimulation tests were assessed. Insulin resistance parameters were calculated using the homeostasis model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) models. Results: BA, BA advancement, free estradiol index, insulin, and HOMA-IR increased significantly in girls with high body mass index (BMI) compared with that of girls with low BMI in cases of CPP. HOMA-IR was positively correlated with BA advancement and BMI but negatively correlated with SHBG. QUICKI was negatively correlated with BA advancement and BMI and positively correlated with SHBG. When HOMA-IR increased by 1, the odds for BA advancement increased 120% after adjusting for age and BMI (P=0.033). Conclusion: Insulin resistance could be associated with BA advancement in girls with CPP.
Abstract
Purpose: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study was to determine whether insulin resistance is associated with bone age (BA) advancement in girls with CPP. Methods: We retrospectively analyzed the records of 804 girls referred for puberty evaluation. Anthropometric measurements, BA, sex hormone, sex hormone binding globulin (SHBG), and insulin levels, lipid profiles, and gonadotropin releasing hormone stimulation tests were assessed. Insulin resistance parameters were calculated using the homeostasis model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) models. Results: BA, BA advancement, free estradiol index, insulin, and HOMA-IR increased significantly in girls with high body mass index (BMI) compared with that of girls with low BMI in cases of CPP. HOMA-IR was positively correlated with BA advancement and BMI but negatively correlated with SHBG. QUICKI was negatively correlated with BA advancement and BMI and positively correlated with SHBG. When HOMA-IR increased by 1, the odds for BA advancement increased 120% after adjusting for age and BMI (P=0.033). Conclusion: Insulin resistance could be associated with BA advancement in girls with CPP.
참고문헌 (30)
- Sørensen K, "Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty", Horm Res Paediatr, 77, pp.137~145 (2012)
- Parent AS, "The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration", Endocr Rev, 24, pp.668~693 (2003)
- 박미정, "한국 청소년의 성성숙 시기 및 장기간의 초경연령 추세분석", Korean Journal of Pediatrics, 49(6), pp.610~616 (2006), 대한소아과학회
- Kim SH, "A significant increase in the incidence of central precocious puberty among Korean girls from 2004 to 2010", PLoS One, 10, pp.e0141844~ (2010)
- Dunger DB, "Effects of obesity on growth and puberty", Best Pract Res Clin Endocrinol Metab, 19, pp.375~390 (2005)
- Byun SH, "The fasting serum glucose, insulin and C-peptide levels in children with obesity", J Korean Soc Pediatr Endocrinol, 8, pp.73~80 (2003)
- DeFronzo RA, "Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease", Diabetes Care, 14, pp.173~194 (1991)
- Lakshman R, "Early age at menarche associated with cardiovascular disease and mortality", J Clin Endocrinol Metab, 94, pp.4953~4960 (2009)
- Bordini B, "Blunted sleeprelated luteinizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index", J Clin Endocrinol Metab, 94, pp.1168~1175 (2009)
- Jasik CB, "Adolescent obesity and puberty: the "perfect storm"", Ann N Y Acad Sci, 1135, pp.265~279 (2008)
- Sørensen K, "Insulin sensitivity and lipid profiles in girls with central precocious puberty before and during gonadal suppression", J Clin Endocrinol Metab, 95, pp.3736~3744 (2010)
- Hillman JB, "Early pubertal development and insulin sensitivity among school-aged girls: mediation via adiposity", J Pediatr Adolesc Gynecol, 26, pp.47~50 (2013)
- Marshall WA, "Variations in pattern of pubertal changes in girls", Arch Dis Child, 44, pp.291~303 (1969)
- Korea Centers for Disease Control and Prevention, "2005 Korean children and adolescents growth standard: commentary for the development of 2005 growth chart" (2005), Korea Centers for Disease Control and Prevention
- Matthews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
- Katz A, "Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans", J Clin Endocrinol Metab, 85, pp.2402~2410 (2000)
- Biro FM, "Influence of obesity on timing of puberty", Int J Androl, 29, pp.272~277 (2006)
- Zimmerman PA, "Hormone-containing cosmetics may cause signs of early sexual development", Mil Med, 160, pp.628~630 (1995)
- Gladen BC, "Pubertal growth and development and prenatal and lactational exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene", J Pediatr, 136, pp.490~496 (2000)
- He Q, "BMI in childhood and its association with height gain, timing of puberty, and final height", Pediatr Res, 49, pp.244~251 (2001)
- Kliegman RM, "Nelson textbook of pediatrics" (2011), Elsevier Saunders
- Møller N, "Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects", Endocr Rev, 30, pp.152~177 (2009)
- Sørensen K, "Serum IGF1 and insulin levels in girls with normal and precocious puberty", Eur J Endocrinol, 166, pp.903~910 (2012)
- Friedrich N, "The association between IGF-I and insulin resistance: a general population study in Danish adults", Diabetes Care, 35, pp.768~773 (2012)
- Södergård R, "Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature", J Steroid Biochem, 16, pp.801~810 (1982)
- 채현욱, "Sex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty", Annals of Pediatirc Endocrinology & Metabolism, 18(2), pp.81~84 (2013), 대한소아내분비학회
- Ahmed ML, "Childhood obesity and the timing of puberty", Trends Endocrinol Metab, 20, pp.237~242 (2009)
- Kaplowitz PB, "Link between body fat and the timing of puberty", Pediatrics, 121(Suppl 3), pp.S208~S217 (2008)
- Kolaczynski JW, "Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro", Diabetes, 45, pp.699~701 (1996)
- Flor-Cisneros A, "Bone age and onset of puberty in normal boys", Mol Cell Endocrinol, 254-255, pp.202~206 (2006)