여성에서 체지방분포와 대사위험요인과의 관련성
Association between body fat distribution and metabolic risk factors in women
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연구배경 대사증후군이란 고중성지방혈증, HDL콜레스테롤저하, 고혈압, 당대사이상 및 복부비만과 같은 관상동맥 위험인자가 함께 나타나는 증후군으로 많은 연구에서 체지방분포 특히 복부 내장지방이 주요한 역할을 하는 것으로 보고하였다. 본 연구에서는 여성에서 CT를 이용하여 측정한 체지방분포와 대사위험요인과의 관련성을 조사하였다. 방 법 2001년 4월부터 2005년 12월까지 단국대병원 비만클리닉을 내원하여 복부 컴퓨터촬영과 체성분분석, 혈액검사 및 신체계측을 시행한 19세 이상의 여성 57명을 대상으로 분석을 시행하였다. 결 과 내장지방면적이 높은 군은 낮은 군에 비해 복부비만, 혈압상승, HDL콜레스테롤 저하 및 중성지방상승의 대사위험요인 빈도가 유의하게 증가하였다. 연령과 체질량지수를 보정한 후에도 내장지방면적이 낮은 군에 비해 높은 군에서 대사위험요인의 교차비가 증가되어 있었고, 중성지방상승에 대한 교차비는 7.3(95% 신뢰구간:1.2-45.3, P=0.033)으로 통계적으로도 유의하였다. 연령과 체질량지수를 보정한 상태에서 대사위험요인의 수가 증가할수록 내장지방면적의 평균값은 증가하였으며, 이는 통계적으로도 유의하였다(Ptrend=0.000). 연령과 체질량지수를 보정한 상태에서 총복부지방면적, 피하지방면적, 내장지방면적, 체지방률을 변수로 시행한 다단계다중회귀분석에서 대사위험요인의 수를 예측할 수 있는 독립변수는 내장지방면적이었다(β=0.013, P=0.000). 결 론 여성에서 복부내장지방은 대사위험요인과 관계가 있었으며, 복부내장지방은 대사위험요인의 군집을 예측할 수 있는 독립적인 요인이었다.
Abstract
Background Metabolic syndrome is clusterings of coronary risk factors. Many studies indicate that body fat distribution especially visceral adipose tissue has an important role in development of metabolic syndrome. This study investigated association of metabolic risk factors and body fat distribution measured by CT in women. Methods From April 2001 to December 2005 we analyzed data of 57 women aged more than 19 years old who visited the obesity clinic of Dankook University Hospital and underwent abdominal fat CT, blood test, bioimpedence analysis and anthropometric measurement. Results Compared to the low visceral fat group, frequencies of metabolic risk factors except for high fasting glucose were increased in high visceral fat group. After adjusted for age and BMI, odds ratios for metabolic risk factors were increased more in high visceral fat group than in low visceral fat group, and odds ratio for high triglyceride(odds ratio=7.3 95% CI: 1.2-45.3, P=0.033) had a statistical significance. Means of visceral fat area were significantly increased as the number of metabolic risk factors increased.(Ptrend=0.000) Stepwise multiple regression analysis showed that visceral fat was an independent variable predicting clusterings of metabolic risk factors.(β=0.013, P=0.000) Conclusions Visceral adipose tissue was associated with metabolic risk factors, and visceral adipose tissue was an independent predictor of clusterings of metabolic risk factors.
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