경동맥 내중막 두께와 혈청 테스토스테론 농도 및 체질량지수와의 관련성
The relationship between the intima-media thickness of the common carotid artery (IMT-CCA), testosterone plasma levels and body mass index (BMI)
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연구배경 본 연구는 혈청 테스토스테론 농도와 경동맥 내중막 두께 증가와의 관련성에 대해 알아보고, 경동맥 내중막 두께에 독립적인 영향을 미치는 변수를 알아보고자 시행되었다. 방 법 일개 대학병원종합검진센터에 내원한 고혈압, 당뇨병, 고지혈증이 없는 성인 남성 64명을 대상으로 신체계측 및 혈청학적 검사를 시행하였으며, B-mode 심초음파를 이용하여 경동맥 내중막 두께를 측정하였다. 결 과 경동맥 내중막 두께와 혈청 총 테스토스테론 및 유리 테스토스테론 간에는 유의한 상관관계가 없었다. 다중회귀 분석에서 경동맥 내중막 두께에 독립적으로 영향을 미치는 변수는 체질량지수였다. 결 론 고혈압, 당뇨병, 고지혈증이 없는 45세 이하의 젊은 한국 성인 남성 64명을 대상으로 시행된 본 연구에서, 체질량지수는 경동맥 내중막 두께와 독립적인 연관성이 있는 유일한 변수였다.
Abstract
Background This study was made to investigate the relationship between testosterone levels and the increased intima-media thickness of the common carotid artery (IMT-CCA). Along with testosterone levels, body mass index (BMI), waist circumference, and other metabolic parameters, were also studied to evaluate whether these subjects have independent effect to the intima-media wall thickness. Methods Total 64 men without hypertension, diabetes mellitus, or hyperlipidemia were enrolled for the study, who were undertaken health screening program in a universial hospital. Anthropometry and blood test were done. The IMT-CCA was estimated by B-mode ultrasound imaging. Results There was no significant correlation between IMT-CCA and serum total or free testosterone levels. In multiple regression analyses, body mass index was the only variable associated with an increased IMT-CCA. Conclusions Body mass index was the only variable associated with IMT-CCA independently in this study group, which were 64 Korean healthy young adult men.
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