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Glycated albumin may have a complementary role to glycated hemoglobin in glucose monitoring in childhood acute leukemia

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주제분류소아과학

초록

Purpose: Glycated hemoglobin (HbA1c) as a glycemic index may have limited value in pediatric patients with acute leukemia as they often present with anemia and/or pancytopenia. To address this issue, we evaluated the usefulness of glycated albumin (GA) as a glycemic monitoring index in pediatric patients with acute leukemia.Methods: Medical records of 25 patients with type 2 diabetes mellitus (T2DM), 63 patients with acute leukemia, and 115 healthy children from Seoul St. Mary's Hospital, The Catholic University of Korea, were retrospectively investigated for serum GA, HbA1c, and fasting blood glucose (FBG) levels, along with demographic data.Results: GA, HbA1c, and FBG levels did not differ between the control and acute leukemia groups. In the T2DM group, positive correlations were observed among GA, HbA1c, and FBG (P<0.01). Although GA level was not associated with the HbA1c level in the control group, GA and HbA1c levels showed a positive correlation in the acute leukemia group (P=0.045). Regression analysis revealed GA and HbA1c levels to be positively correlated in the acute leukemia and T2DM groups even after adjusting for age, sex, and body mass index z-score (P=0.007, P<0.01).Conclusion: GA may be a useful complementary parameter to HbA1c for glycemic monitoring in pediatric patients with acute leukemia, similar to its use in patients with T2DM.

Abstract

Purpose: Glycated hemoglobin (HbA1c) as a glycemic index may have limited value in pediatric patients with acute leukemia as they often present with anemia and/or pancytopenia. To address this issue, we evaluated the usefulness of glycated albumin (GA) as a glycemic monitoring index in pediatric patients with acute leukemia.Methods: Medical records of 25 patients with type 2 diabetes mellitus (T2DM), 63 patients with acute leukemia, and 115 healthy children from Seoul St. Mary's Hospital, The Catholic University of Korea, were retrospectively investigated for serum GA, HbA1c, and fasting blood glucose (FBG) levels, along with demographic data.Results: GA, HbA1c, and FBG levels did not differ between the control and acute leukemia groups. In the T2DM group, positive correlations were observed among GA, HbA1c, and FBG (P<0.01). Although GA level was not associated with the HbA1c level in the control group, GA and HbA1c levels showed a positive correlation in the acute leukemia group (P=0.045). Regression analysis revealed GA and HbA1c levels to be positively correlated in the acute leukemia and T2DM groups even after adjusting for age, sex, and body mass index z-score (P=0.007, P<0.01).Conclusion: GA may be a useful complementary parameter to HbA1c for glycemic monitoring in pediatric patients with acute leukemia, similar to its use in patients with T2DM.

참고문헌 (40)

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관련 논문AI추천

Usefulness of glycated albumin level as a glycemic index complementing glycosylated hemoglobin in diabetic children and adolescentsAhn Moon Bae, Choi Young Ju, Cho Kyoung Soon, Cho Won Kyoung, Jung Min Ho, Kim Shin Hee, Lee Na Yeong, Suh Byung-Kyu대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2023 · 제28권 제4호Serum glycated albumin as a new glycemic marker in pediatric diabetes권영세, 김순기, 김형진, 이지우, 이지은, 전용훈, 최종원대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2013 · 제18권 제4호Clinical usefulness of the measurement of serum fructosamine in childhood diabetes mellitus강동수, 김재경, 박지연, 유지숙대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2015 · 제20권 제1호Association between hemoglobin glycation index and cardiometabolic risk factors in Korean pediatric nondiabetic population김재현, 신충호, 양세원, 이보라, 이승용, 이영아, 이지은, 허유정대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2018 · 제23권 제4호Value of serum 1,5-anhydroglucitol measurements in childhood obesity in the continuum of diabetes김교순, 손재성, 정소정, Byung Ok Kwak, Ha Yeong Yoo대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2015 · 제20권 제4호Update on the current modalities used to screen high risk youth for prediabetes and/or type 2 diabetes mellitusPreneet Cheema Brar대한소아내분비학회 · Annals of Pediatric Endocrinology & Metabolism2019 · 제24권 제2호

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