뇌병변 장애인의 심폐체력과 염증반응 지표 및 뇌졸중 위험요인의 관련성
The Association between Cardiorespiratory Fitness, Inflammation Marker and Stroke Risk Factor in Chronic Stroke Patients
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참고문헌
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초록
본 연구의 목적은 뇌병변 장애인 중 뇌졸중 환자들을 대상으로 심폐체력과 염증반응 지표 및 뇌졸중 위험요인과의 관련성을 분석하는데 있다. 본 연구는 80명의 뇌졸중 환자를 대상으로 실시하였다. 여성 뇌졸중 환자는 남성보다 체지방량(p<.001), 총콜레스테롤(p<.05), 고밀도지단백질 콜레스테롤(p<.05)이 높은 것으로 나타났으며, 남성 뇌졸중 환자는 호모시스테인 농도(p<.001)과 hsCRP 수준(p<.05)이 여성보다 높은 것으로 나타났다. 전체적으로 백혈구 수는 체질량지수(p<.05) 및 공복 시 혈당(p<.01)과 유의한 양의 상관관계를 나타내었으며, 고밀도지단백질 콜레스테롤(p<.01)과 유의한 음의 상관관계를 나타내었다. Fibrinogen은 체지방률(p<.01)과 유의한 양의 상관관계를 나타내었다. oxLDL은 총콜레스테롤(p<.01) 및 호모시스테인(p<.05)과 유의한 양의 관련성을 나타내었다. 심폐체력은 체질량지수(p<.05), 체지방량(p=.01)과 음의 관련성을 나타내었다. 이상의 결과를 종합해보면 본 연구의 뇌졸중 환자들은 염증반응 지표 중 백혈구 수와 혈중 oxLDL 수준이 증가되어 있으며, 이러한 염증지표가 뇌졸중 위험과 관련이 높은 것으로 나타나 염증반응 개선을 통한 뇌졸중 위험요인의 관리가 필요한 것으로 고려된다.
Abstract
The purpose of this study was to investigate the association between cardiorespiratory fitness, inflammation marker and stroke risk factors. The subjects who participated in this study were 80 stroke patients. There was showed that body percent fat(p<.001), total cholesterol(p<.05), and high lipoprotein cholesterol(p<.05) in women were higher than men. On the other hand, homocystein(p<.001) and hsCRP(p<.05) in men were higher than women. White blood cell(WBC) was positively correlated with body mass index(BMI)(p<.05) and fasting blood glucose(FBG) level(p<.01) and negatively correlated with high lipoprotein cholesterol(HDL-C)(p<.01). Fibrinogen was positively correlated with percent body fat(p<.01). OxLDL(oxidative low-density lipoprotein) was positively correlated with total cholesterol(TC)(p<.01) and homocystein(p<.05). Moreover, the cariorespratory fitness was negatively correlated with BMI(p<.05) and body percent fat(p<.01) and positively correlated with HDL-C(p<.05). Consequently, the results of this study demonstrated that the inflammation indices, especially WBC and plasma oxLDL, were up-regulated in stroke patients and these factors have significant relationship with the recurrent stroke events. Therefore, stroke patients in this study were need to manage and treat for the prevention of recurrent stroke events.
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