Leaky Gut in IBD: Intestinal Barrier–Gut Microbiota Interaction

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참고문헌 (123)

1. Kaplan GG, "Understanding and preventing the global increase of inflammatory bowel disease", Gastroenterology, 152, pp.313~321 (2017)
2. Ananthakrishnan AN, "Epidemiology and risk factors for IBD", Nat. Rev. Gastroenterol. Hepatol, 12, pp.205~217 (2015)
3. Sudabeh Alatab, "The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017", The Lancet Gastroenterology & Hepatology, 5(1), pp.17~30 (2020), Elsevier BV[DOI]
4. Yu LC, "Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers : exploring a common ground hypothesis", J. Biomed. Sci, 25, pp.79~ (2018)
5. Parikh K, "Colonic epithelial cell diversity in health and inflammatory bowel disease", Nature, 567, pp.49~55 (2019)
6. Camilleri M, "Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome.", Am. J. Physiol. Gastrointest. Liver Physiol, 303, pp.775~785 (2012)
7. Vetrano S, "Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation", Proc. Nat. Acad. Sci. USA, 108, pp.19830~19835 (2011)
8. Arumugam M, "Enterotypes of the human gut microbiome", Nature, 473, pp.174~180 (2011)
9. Lynch SV, "The human intestinal microbiome in health and disease", New Eng. J. Med, 375, pp.2369~2379 (2016)
10. Imhann F, "Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease", Gut, 67, pp.108~119 (2018)
11. Kolho KL, "Fecal microbiota in pediatric inflammatory bowel disease and its relation to inflammation", Am. J. Gastroenterol, 110, pp.921~930 (2015)
12. Chen L, "Characteristics of fecal and mucosa-associated microbiota in Chinese patients with inflammatory bowel disease", Medicine, 93, pp.e51~ (2014)
13. Zhou Y, "Increased Enterococcus faecalis infection is associated with clinically active Crohn disease", Medicine, 95, pp.e5019~ (2016)
14. Prosberg M, "The association between the gut microbiota and the inflammatory bowel disease activity : a systematic review and meta-analysis", Scandinavian J. Gastroenterology, 51, pp.1407~1415 (2016)
15. Maukonen J, "Altered fecal microbiota in paediatric inflammatory bowel disease", J. Crohn's Colitis, 9, pp.1088~1095 (2015)
16. Johansson ME, "The gastrointestinal mucus system in health and disease", Nat. Rev. Gastroenterol. Hepatol, 10, pp.352~361 (2013)
17. Johansson ME, "Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis", Gut, 63, pp.281~291 (2014)
18. Swidsinski A, "Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease", J. Clin. Microbiol, 43, pp.3380~3389 (2005)
19. Motta JP, "Iron sequestration in microbiota biofilms as a novel strategy for treating inflammatory bowel disease", Inflamm. Bowel Dis, 24, pp.1493~1502 (2018)
20. Carlsson AH, "Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis", Scand. J. Gastroenterol, 48, pp.1136~1144 (2013)
21. Mohebali N, "Barrier protection and recovery effects of gut commensal bacteria on differentiated intestinal epithelial cells in vitro", Nutrients, 12, pp.2251~ (2020)
22. Laval L, "Lactobacillus rhamnosus CNCM I-3690and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyperpermeability in mice", Gut Microbes, 6, pp.1~9 (2015)
23. Geerlings SY, "Akkermansia muciniphila in the human gastrointestinal tract : When, where, and how?", Microorganisms, 6, pp.75~ (2018)
24. Bian X, "Administration of Akkermansia muciniphila ameliorates dextran sulfate sodium-induced ulcerative colitis in mice", Front. Microbiol, 10, pp.2259~ (2019)
25. Wang L, "A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8(+)T cells in mice", Gut, 69, pp.1988~1997 (2020)
26. Qian K, "A β-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila protects against dextran sulfate sodium-induced colitis in mice by enhancing intestinal barrier and modulating gut microbiota", Food Funct, 13, pp.2216~2227 (2022)
27. Shin J, "Elucidation of Akkermansia muciniphila probiotic traits driven by mucin depletion", Front. Microbiol, 10, pp.1137~ (2019)
28. van der Lugt B, "Akkermansia muciniphila ameliorates the agerelated decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1-", Δ7 mice, 2019, pp.16, 6~
29. Plovier H, "A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice", Nat. Med, 23, pp.107~113 (2017)
30. Panpetch W, "Additional Candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by Lactobacillus rhamnosus L34", Gut Microbes, 11, pp.465~480 (2020)
31. White R, "Randomized, controlled trial evaluating the effect of multistrain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease", Gut Microbes, 8, pp.451~466 (2017)
32. Fan H, "Effects of pentasa-combined probiotics on the microflora structure and prognosis of patients with inflammatory bowel disease", Turk. J. Gastroenterol, 30, pp.680~685 (2019)
33. Yılmaz İ, "Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease : A randomized controlled trial", Turk. J. Gastroenterol, 30, pp.242~253 (2019)
34. Ballini A, "Probiotics efficacy on oxidative stress values in inflammatory bowel disease : A randomized double-blinded placebo-controlled pilot study", Endocr. Metab. Immune Disord. Drug Targets, 19, pp.373~381 (2019)
35. Fan L, "B. adolescentis ameliorates chronic colitis by regulating Treg", Th2 response and gut microbiota remodeling, 2021, pp.3, 1~17
36. Ambort D, "Perspectives on mucus properties and formation--lessons from the biochemical world", Cold Spring Harb. Perspect. Med, 2, pp.014159~ (2012)
37. Bergstrom K, "Core 1-and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice", Mucosal Immunol, 10, pp.91~103 (2017)
38. Kudelka MR, "Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk", Proc. Nat. Acad. Sci. USA, 113, pp.14787~14792 (2016)
39. Moran AP, "Sweet-talk : role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract", Gut, 60, pp.1412~1425 (2011)
40. Larsson JM, "Altered O-glycosylation profile of MUC2mucin occurs in active ulcerative colitis and is associated with increased inflammation", Inflamm. Bowel Dis, 17, pp.2299~2307 (2011)
41. Bergstrom KS, "Mucin-type O-glycans and their roles in intestinal homeostasis", Glycobiology, 23, pp.1026~1037 (2013)
42. Wells JM, "Homeostasis of the gut barrier and potential biomarkers", Am. J. Physiol. Gastrointest. Liver Physiol, 312, pp.171~193 (2017)
43. Quigley EM, "Leaky gut-concept or clinical entity?", Curr. Opin. Gastroenterol, 32, pp.74~79 (2016)
44. Bergström JH, "Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16", Proc. Nat. Acad. Sci. USA, 113, pp.13833~13838 (2016)
45. Desai MS, "A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility", Cell, 167, pp.1339~1353 (2016)[DOI]
46. Okumura R, "Maintenance of intestinal homeostasis by mucosal barriers", Inflamm. Regen, 38, pp.5~ (2018)
47. Liso M, "A Specific mutation in Muc2 determines early dysbiosis in colitis-prone winnie mice", Inflamm. Bowel Dise, 26, pp.546~556 (2020)
48. Dharmani P, "Role of intestinal mucins in innate host defense mechanisms against pathogens", J. Innate Immun, 1, pp.123~135 (2009)
49. Jakobsson HE, "The composition of the gut microbiota shapes the colon mucus barrier", EMBO Rep, 16, pp.164~177 (2015)
50. Johansson ME, "Normalization of host intestinal mucus layers requires long-term microbial colonization", Cell Host Microbe, 18, pp.582~592 (2015)
51. Turpin W, "Increased intestinal permeability is associated with later development of Crohn's disease", Gastroenterology, 159, pp.2092~2100 (2020)[DOI]
52. Cornick S, "Roles and regulation of the mucus barrier in the gut", Tissue Barriers, 3, pp.e982426~ (2015)
53. Heazlewood CK, "Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis", PLoS Med, 5, pp.e54~ (2008)
54. Hasnain SZ, "IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells", Gastroenterology, 144, pp.357~368 (2013)[DOI]
55. Liu H, "Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism", JCI Insight, 4, pp.e131273~ (2019)
56. Ocansey DKW, "Exosome-mediated effects and applications in inflammatory bowel disease", Biol. Rev. Camb. Philos. Soc, 95, pp.1287~1307 (2020)
57. Teng Y, "Plant-derived exosomal microRNAs shape the gut microbiota", Cell Host Microbe, 24, pp.637~652 (2018)[DOI]
58. Gu L, "Exosomal microRNA-181a derived from mesenchymal stem cells improves gut microbiota composition, barrier function, and inflammatory status in an experimental colitis model", Front. Med, 8, pp.660614~ (2021)
59. Alexander M, "Exosome-delivered microRNAs modulate the inflammatory response to endotoxin", Nat. Commun, 6, pp.7321~ (2015)
60. Nata T, "MicroRNA-146b improves intestinal injury in mouse colitis by activating nuclear factor-κB and improving epithelial barrier function", J. Gene Med, 15, pp.249~260 (2013)
61. Leoni G, "Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair", J. Clin. Investig, 125, pp.1215~1227 (2015)
62. Das I, "Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins", J. Exp. Med, 210, pp.1201~1216 (2013)
63. Martini E, "Mend your fences : The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease", Cell. Mol. Gastroenterol. Hepatol, 4, pp.33~46 (2017)
64. Mowat AM, "Regional specialization within the intestinal immune system", Nat. Rev. Immunol, 14, pp.667~685 (2014)
65. Schulthess J, "The short chain fatty acid butyrate imprints an antimicrobial program in macrophages", Immunity, 50, pp.432~445 (2019)[DOI]
66. Kang B, "Commensal microbiota drive the functional diversification of colon macrophages", Mucosal Immunol, 13, pp.216~229 (2020)
67. Chikina AS, "Macrophages maintain epithelium integrity by limiting fungal product absorption", Cell, 183, pp.411~428 (2020)[DOI]
68. Bain CC, "Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors", Mucosal Immunol, 6, pp.498~510 (2013)
69. Mantovani A, "The chemokine system in diverse forms of macrophage activation and polarization", Trends Immunol, 25, pp.677~686 (2004)
70. Gordon S, "Alternative activation of macrophages : mechanism and functions", Immunity, 32, pp.593~604 (2010)
71. Nalle SC, "Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versushost disease", Mucosal Immunol, 8, pp.720~730 (2015)
72. Rubio CA, "Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis", Histopathology, 72, pp.580~587 (2018)
73. Vivier E, "Innate lymphoid cells : 10 years on", Cell, 174, pp.1054~1066 (2018)
74. Yoshiyuki Goto, "Intestinal epithelial cells as mediators of the commensal–host immune crosstalk", Immunology & Cell Biology, 91(3), pp.204~214 (2013), Wiley[DOI]
75. Pickard JM, "Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness", Nature, 514, pp.638~641 (2014)
76. Ibiza S, "Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence", Nature, 535, pp.440~443 (2016)
77. Godinho-Silva C, "Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis", Nature, 574, pp.254~258 (2019)
78. Buela KA, "Cross-talk between type 3 innate lymphoid cells and the gut microbiota in inflammatory bowel disease", Curr. Opin. Gastroenterol, 31, pp.449~455 (2015)
79. von Moltke J, "Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit", Nature, 529, pp.221~225 (2016)
80. Kiss EA, "Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles", Science, 334, pp.1561~1565 (2011)
81. Li Y, "Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation", Cell, 147, pp.629~640 (2011)
82. Qiu J, "The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells", Immunity, 36, pp.92~104 (2012)
83. Matarrese P, "Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria. Involvement of ATP-sensitive mitochondrial potassium channels", J. Biol. Chem, 282, pp.9029~9041 (2007)
84. Dean P, "Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein", Mol. Microbiol, 54, pp.665~675 (2004)
85. Phillip A. Swanson, "Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases", Proceedings of the National Academy of Sciences, 108(21), pp.8803~8808 (2011), Proceedings of the National Academy of Sciences[DOI]
86. Saxena A, "Absence of the NOD2 protein renders epithelia more susceptible to barrier dysfunction due to mitochondrial dysfunction", Am. J. Physiol. Gastroint. Liver Physiol, 313, pp.26~38 (2017)
87. Söderholm JD, "Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease", Gut, 50, pp.307~313 (2002)
88. Rao R, "Oxidative stress-induced disruption of epithelial and endothelial tight junctions", Front. Biosci, 13, pp.7210~7226 (2008)
89. Gangwar R, "Calcium-mediated oxidative stress : a common mechanism in tight junction disruption by different types of cellular stress", Biochem. J, 474, pp.731~749 (2017)
90. Reed DE, "Mast cell tryptase and proteinaseactivated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons", J. Physiol, 547, pp.531~542 (2003)
91. Kulka M, "Neuropeptides activate human mast cell degranulation and chemokine production", Immunology, 123, pp.398~410 (2008)
92. Huh JR, "Neuroimmune circuits in inter-organ communication", Nat. Rev. Immunol, 20, pp.217~228 (2020)
93. Muller PA, "Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility", Cell, 158, pp.300~313 (2014)
94. Gabanyi I, "Neuro-immune interactions drive tissue programming in intestinal macrophages", Cell, 164, pp.378~391 (2016)
95. Matheis F, "Adrenergic signaling in muscularis macrophages limits infection-induced neuronal loss", Cell, 180, pp.64~78 (2020)[DOI]
96. Levy M, "Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling", Cell, 163, pp.1428~1443 (2015)
97. Jarret A, "Enteric nervous system-derived IL-18 Orchestrates Mucosal barrier immunity", Cell, 180, pp.50~63 (2020)[DOI]
98. Lai NY, "Gut-innervating nociceptor neurons regulate Peyer's patch microfold cells and SFB levels to mediate Salmonella host defense", Cell, 180, pp.33~49 (2020)[DOI]
99. Kabouridis PS, "Microbiota controls the homeostasis of glial cells in the gut lamina propria", Neuron, 85, pp.289~295 (2015)
100. Ge X, "Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility", J. Transl. Med, 15, pp.13~ (2017)
101. McVey Neufeld KA, "The gut microbiome restores intrinsic and extrinsic nerve function in germ-free mice accompanied by changes in calbindin", Neurogastroenterol. Motil, 27, pp.627~636 (2015)
102. Al-Nedawi K, "Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems", FASEB J, 29, pp.684~695 (2015)
103. Mao YK, "Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons", Nat. Commun, 4, pp.1465~ (2013)
104. Khoshdel A, "Bifidobacterium longum NCC3001 inhibits AH neuron excitability", Neurogastroenterol. Motil, 25, pp.478~484 (2013)
105. Duboc H, "Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases", Gut, 62, pp.531~539 (2013)
106. Lajczak-McGinley NK, "The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis", Physiol. Rep, 8, pp.e14456~ (2020)
107. Golden JM, "Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR-and COX-2-dependent mechanisms", Am. J. Physiol. Gastrointest. Liver Physiol, 315, pp.259~271 (2018)
108. Lien Van den Bossche, "Ursodeoxycholic Acid and Its Taurine- or Glycine-Conjugated Species Reduce Colitogenic Dysbiosis and Equally Suppress Experimental Colitis in Mice", Applied and Environmental Microbiology, 83(7) (2017), American Society for Microbiology[DOI]
109. Ward JBJ, "Ursodeoxycholic acid and lithocholic acid exert antiinflammatory actions in the colon", Am. J. Physiol. Gastrointest. Liver Physiol, 312, pp.550~558 (2017)
110. Sinha SR, "Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation", Cell Host Mcrobe, 27, pp.659~670 (2020)
111. Smith PM, "The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis", Science, 341, pp.569~573 (2013)
112. Chen G, "Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model", EBioMedicine, 30, pp.317~325 (2018)
113. Zheng L, "Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2", J. Immunol, 199, pp.2976~2984 (2017)
114. Miao W, "Sodium butyrate promotes reassembly of tight junctions in Caco-2Monolayers involving inhibition of MLCK", MLC2 pathway and phosphorylation of PKCβ2, 2016, pp.17, 1696~
115. Valenzano MC, "Remodeling of tight junctions and enhancement of barrier integrity of the CACO-2 intestinal epithelial cell layer by micronutrients", PLoS One, 10, pp.e0133926~ (2015)
116. Yan H, "Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway", PLoS One, 12, pp.e0179586~ (2017)
117. Wang HB, "Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein Claudin-1 transcription", Dig. Dis. Sci, 57, pp.3126~3135 (2012)
118. Li X, "An insight into the roles of dietary tryptophan and its metabolites in intestinal inflammation and inflammatory bowel disease", Mol. Nutr. Food Res, 65, pp.e2000461~ (2021)
119. Borisova MA, "Fucose ameliorates tryptophan metabolism and behavioral abnormalities in a mouse model of chronic colitis", Nutrients, 12, pp.445~ (2020)
120. Gasaly N, "Impact of bacterial metabolites on gut barrier function and host immunity : A focus on bacterial metabolism and its relevance for intestinal inflammation", Front. Immunol, 12, pp.658354~ (2021)
121. Carbazole is a nanomolar UVA photosensitizer in epidermal keratinocytes, "J. Investig. Dermatol", 2015, 1649~1658
122. Yamada T, "Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense", Nat. Immunol, 17, pp.687~694 (2016)
123. Lamas B, "CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands", Nat. Med, 22, pp.598~605 (2016)

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