Identification and Validation of Novel Biomarkers and Potential Targeted Drugs in Cholangiocarcinoma: Bioinformatics, Virtual Screening, and Biological Evaluation

키워드

참고문헌 (44)

1. Khan SA, "Cholangiocarcinoma : Epidemiology and risk factors", Liver Int, 39(1), pp.19~31 (2019)
2. Boris Blechacz, "Cholangiocarcinoma: Current Knowledge and New Developments", Gut and Liver, 11(1), pp.13~26 (2017), 거트앤리버 소화기연관학회협의회
3. Rodrigues PM, "Pathogenesis of cholangiocarcinoma", Annu. Rev. Pathol, 16, pp.433~463 (2021)
4. Cardinale V, "Cholangiocarcinoma : increasing burden of classifications", Hepatobiliary Surg. Nutr, 2, pp.272~280 (2013)
5. Valle JW, "Biliary tract cancer", Lancet, 397, pp.428~444 (2021)
6. Gigante E, "New insights into the pathophysiology and clinical care of rare primary liver cancers", JHEP Rep, 3, pp.100174~ (2021)
7. Coelho R, "CA 19-9 as a marker of survival and a predictor of metastization in cholangiocarcinoma", GE Port. J. Gastroenterol, 24, pp.114~121 (2017)
8. Rizvi S, "Cholangiocarcinoma-evolving concepts and therapeutic strategies", Nat. Rev. Clin. Oncol, 15, pp.95~111 (2018)
9. Banales JM, "Cholangiocarcinoma 2020 : the next horizon in mechanisms and management", Nat. Rev. Gastroenterol. Hepatol, 17, pp.557~588 (2020)
10. Lee YT, "Molecular targeted therapy : Treating cancer with specificity", Eur. J. Pharmacol, 834, pp.188~196 (2018)
11. Bayat A, "Science, medicine, and the future : Bioinformatics", BMJ, 324, pp.1018~1022 (2002)
12. Manzoni C, "Genome, transcriptome and proteome : the rise of omics data and their integration in biomedical sciences", Brief. Bioinform, 19, pp.286~302 (2018)
13. Pereira CA, "Computational approaches for drug discovery against trypanosomatid-caused diseases", Parasitology, 147, pp.611~633 (2020)
14. Iqbal D, "High-throughput screening and molecular dynamics simulation of natural product-like compounds against Alzheimer's disease through multitarget approach", Pharmaceuticals(Basel), 14, pp.937~ (2021)
15. Batool M, "A structure-based drug discovery paradigm", Int. J. Mol. Sci, 20, pp.2783~ (2019)
16. Alamri MA, "Pharmacophore and docking-based sequential virtual screening for the identification of novel Sigma 1 receptor ligands", Bioinformation, 15, pp.586~595 (2019)
17. Chen Z, "Pharmacophore-based virtual screening versus docking-based virtual screening : a benchmark comparison against eight targets", Acta Pharmacol. Sin, 30, pp.1694~1708 (2009)
18. Clough E, "The gene expression omnibus database", Methods Mol. Biol, 1418, pp.93~110 (2016)
19. Wang Z, "A practical guide to the cancer genome atlas(TCGA)", Methods Mol. Biol, 1418, pp.111~141 (2016)
20. Ritchie ME, "limma powers differential expression analyses for RNA-sequencing and microarray studies", Nucleic Acids Res, 43, pp.e47~ (2015)
21. Robinson MD, "edgeR : a Bioconductor package for differential expression analysis of digital gene expression data", Bioinformatics, 26, pp.139~140 (2010)
22. Barrett T, "NCBI GEO : archive for functional genomics data sets-update", Nucleic Acids Res, 41, pp.991~995 (2013)
23. Huang da W, "Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources", Nat. Protoc, 4, pp.44~57 (2009)
24. Szklarczyk D, "The STRING database in 2017 : quality-controlled protein-protein association networks, made broadly accessible", Nucleic Acids Res, 45, pp.362~368 (2017)
25. Su G, "Biological network exploration with Cytoscape 3", Curr. Protoc. Bioinformatics, 47, pp.8~ (2014)[DOI]
26. Chin CH, "cytoHubba : identifying hub objects and sub-networks from complex interactome", BMC Syst. Biol, 8(S11), pp.S11~ (2014)
27. Tang Z, "GEPIA : a web server for cancer and normal gene expression profiling and interactive analyses", Nucleic Acids Res, 45, pp.98~102 (2017)
28. Agarwal V, "Predicting effective microRNA target sites in mammalian mRNAs", Elife, 4, pp.e05005~ (2015)
29. Wong NW, "OncomiR : an online resource for exploring pan-cancer microRNA dysregulation", Bioinformatics, 34, pp.713~715 (2018)
30. Sunseri J, "Pharmit : interactive exploration of chemical space", Nucleic Acids Res, 44, pp.442~448 (2016)
31. Wood DJ, "Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition", Cell. Chem. Biol, 26, pp.121~130 (2019)
32. Molvarec A, "Preeclampsia is associated with decreased serum alpha(2)-HS glycoprotein(fetuin-A)concentration", Hypertens. Res, 32, pp.665~669 (2009)
33. Palta S, "Overview of the coagulation system", Indian J. Anaesth, 58, pp.515~523 (2014)
34. Wieczorek E, "Transthyretin : from structural stability to osteoarticular and cardiovascular diseases", Cells, 10, pp.1768~ (2021)
35. Peyrou M, "The kallikrein-kinin pathway as a mechanism for auto-control of brown adipose tissue activity", Nat. Commun, 11, pp.2132~ (2020)
36. Zamolodchikov D, "Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity", Alzheimers Dement, 18, pp.1919~1929 (2022)
37. Feinstein DI, "Disseminated intravascular coagulation in patients with solid tumors", Oncology(Williston Park), 29, pp.96~102 (2015)
38. Chen D, "Five hub genes can be the potential DNA methylation biomarkers for cholangiocarcinoma using bioinformatics analysis", Onco Targets Ther, 12, pp.8355~8365 (2019)
39. Ding L, "The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer", Int. J. Mol. Sci, 21, pp.1960~ (2020)
40. Strzalka W, "Proliferating cell nuclear antigen(PCNA) : a key factor in DNA replication and cell cycle regulation", Ann. Bot, 107, pp.1127~1140 (2011)
41. De March M, "p15PAF binding to PCNA modulates the DNA sliding surface", Nucleic Acids Res, 46, pp.9816~9828 (2018)
42. Hanahan D, "Hallmarks of cancer : the next generation", Cell, 144, pp.646~674 (2011)
43. Robert Roskoski, "Cyclin-dependent protein serine", threonine kinase inhibitors as anticancer drugs, 2019, pp.139, 471~488[DOI]
44. Kommalapati A, "FGFR inhibitors in oncology : Insight on the management of toxicities in clinical practice", Cancers(Basel), 13, pp.2968~ (2021)

관련 논문AI추천