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Innovative Bacterial Therapies and Genetic Engineering Approaches in Colorectal Cancer: A Review of Emerging Strategies and Clinical Implications

Song Chunxiao|Zhao Chunwu
한국미생물·생명공학회 (The Korean Society For Microbiology And Biotechnology)|2024.12|Journal of Microbiology and Biotechnology|제34권 제12호|pp. 2397-2412|DOI 10.4014/jmb.2408.08026

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키워드

CRISPR-Cas9Microbiotagenetic engineeringbacteriophage therapychromosome instability
주제분류생물학

초록

Colorectal cancer (CRC) is considered a widespread cancer, ranking second in mortality and incidence among cancer patients worldwide. CRC develops from adenoma to carcinoma through the dynamic interplay of genetic and environmental factors. The conventional modes of treatment, including operation, chemotherapy, and irradiation, are associated with significant challenges, such as drug resistance and toxicity, necessitating the exploration of new treatment modalities. These difficulties reveal the necessity of the emergence of new therapeutic approaches. This review mainly emphasizes the bacterial-based therapies that have recently developed like the engineered bacteriophage therapy and bacterial immunotherapy that pale the existing chemotherapy in terms of toxicity but are effective in killing tumor cells. Also, it also investigates various molecular genetic engineering strategies such as CRISPR-Cas9, CRISPR prime editing and gene silencing to achieve better targeting of CRC. Implementing these new approaches into the forefront of CRC treatment may bring better, more effective therapy with fewer side effects on patients’ quality of life.

Abstract

Colorectal cancer (CRC) is considered a widespread cancer, ranking second in mortality and incidence among cancer patients worldwide. CRC develops from adenoma to carcinoma through the dynamic interplay of genetic and environmental factors. The conventional modes of treatment, including operation, chemotherapy, and irradiation, are associated with significant challenges, such as drug resistance and toxicity, necessitating the exploration of new treatment modalities. These difficulties reveal the necessity of the emergence of new therapeutic approaches. This review mainly emphasizes the bacterial-based therapies that have recently developed like the engineered bacteriophage therapy and bacterial immunotherapy that pale the existing chemotherapy in terms of toxicity but are effective in killing tumor cells. Also, it also investigates various molecular genetic engineering strategies such as CRISPR-Cas9, CRISPR prime editing and gene silencing to achieve better targeting of CRC. Implementing these new approaches into the forefront of CRC treatment may bring better, more effective therapy with fewer side effects on patients’ quality of life.

참고문헌 (147)

  1. Xi Y, "Global colorectal cancer burden in 2020 and projections to 2040", Transl. Oncol, 14, pp.101174~ (2021)
  2. Sawicki T, "A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis", Cancers, 13, pp.2025~ (2021)
  3. Liss J, "Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer’s disease(MCI and dementia)in primary care : a review and synthesis", J. Internal Med, 290, pp.310~334 (2021)
  4. Rawla P, "Epidemiology of colorectal cancer : incidence, mortality, survival, and risk factors", Gastroenterol, 14, pp.89~103 (2019)
  5. Cavalli G, "Advances in epigenetics link genetics to the environment and disease", Nature, 571, pp.489~499 (2019)
  6. Ratajczak W, "Immunomodulatory potential of gut microbiome-derived short-chain fatty acids(SCFAs)", Acta Biochim. Pol, 66, pp.1~12 (2019)
  7. Henderson EA, "Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer", Front. Oncol, 13, pp.1217095~ (2023)
  8. Saeed M, "Microbe-based therapies for colorectal cancer : advantages and limitations", Semin. Cancer Biol, 86, pp.652~665 (2022)
  9. Ternes D, "The gut microbial metabolite formate exacerbates colorectal cancer progression", Nat. Metab, 4, pp.458~475 (2022)
  10. Ren JJ, "Effectiveness and safety of moxibustion for poststroke insomnia : a systematic review and meta-analysis", World J. Tradit. Chin. Med, 8, pp.199~209 (2022)
  11. Pucci C, "Innovative approaches for cancer treatment : current perspectives and new challenges", Ecancermedicalscience, 13, pp.961~ (2019)
  12. Mueller AL, "Bacteria-mediated modulatory strategies for colorectal cancer treatment", Biomedicines, 10, pp.832~ (2022)
  13. Tornesello AL, "Antimicrobial peptides as anticancer agents : functional properties and biological activities", Molecules, 25, pp.2850~ (2020)
  14. Baindara P, "Bacteria and bacterial anticancer agents as a promising alternative for cancer therapeutics", Biochimie, 177, pp.164~189 (2020)
  15. Allemailem KS, "Current updates of CRISPR", Cas9-mediated genome editing and targeting within tumor cells : an innovative strategy of cancer management, 2022, pp.42, 1257~1287
  16. Liu Y, "Genetically engineered bacterium : principles, practices, and prospects", Front. Microbiol, 13, pp.997587~ (2022)
  17. Liu X, "Effect of herb-partitioned moxibustion on structure and functional prediction of gut microbiota in rats with irritable bowel syndrome with diarrhea", World J. Tradit. Chin. Med, 9, pp.141~149 (2023)
  18. Li J, "Genetic and biological hallmarks of colorectal cancer", Genes Dev, 5, pp.787~820 (2021)
  19. Zhang ZJ, "The psychosomatic thought of tibetan medicine and its treatment methods", World J. Tradit. Chin. Med, 9, pp.330~337 (2023)
  20. Lustig B, "The Wnt signaling pathway and its role in tumor development", J. Cancer Res. Clin. Ooncol, 129, pp.199~221 (2003)
  21. Castagnola P, "KRAS, chromosomal instability and prognosis in colorectal cancer", Biochim. Biophys. Acta (BBA)-Reviews on Cancer, 1756, pp.115~125 (2005)
  22. Duffy MJ, "Targeting p53 for the treatment of cancer", Semin. Cancer Biol, 79, pp.58~67 (2022)
  23. Adeleke S, "Microsatellite instability testing in colorectal patients with Lynch syndrome : lessons learned from a case report and how to avoid such pitfalls", Per. Med, 19, pp.277~286 (2022)
  24. Baretti M, "DNA mismatch repair in cancer", Pharmacol. Ther, 189, pp.45~62 (2018)
  25. Li WX, "Pharmacokinetic comparison of four major bio-active components of naoxintong capsule in normal and acute blood stasis rats using ultra-performance liquid chromatography coupled with triple-quadrupole mass spectrometry", World J. Trad. Chin. Med, 8, pp.92~99 (2022)
  26. Cerretelli G, "Molecular pathology of Lynch syndrome", J. Pathol, 250, pp.518~531 (2022)
  27. Huang H, "IFI27 is a potential therapeutic target for HIV infection", Ann. Med, 54, pp.314~325 (2022)
  28. Gu S, "Genome-wide methylation profiling identified novel differentially hypermethylated biomarker MPPED2 in colorectal cancer", Clin. Epigenetics, 11, pp.41~ (2019)
  29. Li ZN, "BRAF and KRAS mutations in metastatic colorectal cancer : future perspectives for personalized therapy", Gastroenterol. Rep, 8, pp.192~205 (2020)
  30. Mattiuzzi C, "Concise update on colorectal cancer epidemiology", Ann. Transl. Med, 7, pp.609~ (2019)
  31. Zhou J, "Colorectal cancer burden and trends : comparison between China and major burden countries in the world", Chinese J. Cancer Res, 33, pp.1~10 (2021)
  32. Ye J, "Effect of salivary antimicrobial factors on microbial composition of tongue coating in patients with coronary heart disease with phlegm-stasis syndrome", World J. Tradit. Chin. Med, 8, pp.123~130 (2022)
  33. Morgan E, "Global burden of colorectal cancer in 2020 and 2040 : incidence and mortality estimates from GLOBOCAN", Gut, 72, pp.338~344 (2023)
  34. Yao X, "A novel image encryption scheme for DNA storage systems based on DNA hybridization and gene mutation", Interdiscip. Sci, 15, pp.419~432 (2023)
  35. Moura AR, "Trends in the incidence and mortality of colorectal cancer in a brazilian city", BMC Res. Notes, 13, pp.560~ (2020)
  36. Han JY, "Progression of the Wei-Qi-Ying-Xue syndrome, microcirculatory disturbances, in infectious diseases and treatment with traditional Chinese medicine", World J. Tradit. Chin. Med, 8, pp.169~180 (2022)
  37. Center MM, "Worldwide variations in colorectal cancer", CA Cancer J. Clin, 59, pp.366~378 (2009)
  38. Parkin DM, "The global health burden of infection-associated cancers in the year 2002", Int. J. Cancer, 118, pp.3030~3044 (2006)
  39. Hossain MS, "Colorectal cancer : a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies", Cancers, 14, pp.1732~ (2022)
  40. Coman IS, "Emergency and elective colorectal cancer—Relationship between clinical factors, tumor topography and surgical strategies : a cohort study", Medicina, 60, pp.898~ (2024)
  41. Ma JY, "Therapeutics of integrative medicine ameliorate immunological disorders of the nervous system : a meta-analysis", World J. Tradit. Chin. Med, 8, pp.153~167 (2022)
  42. Hatton GB, "All disease begins in the gut : influence of gastrointestinal disorders and surgery on oral drug performance", Int. J. Pharm, 548, pp.408~422 (2018)
  43. Kumar M, "Futuristic non-antibiotic therapies to combat antibiotic resistance : a review", Front. Microbiol, 12, pp.609459~ (2021)
  44. Khan I, "Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome", Pathogens, 8, pp.126~ (2019)
  45. Wang X, "Effects of ferulic acid on regulating the neurovascular unit : implications for ischemic stroke treatment", World J. Tradit. Chin. Med, 8, pp.210~217 (2022)
  46. Javdan B, "Drug metabolism by the human gut microbiome: an investigation of metabolic capacity, interpersonal variability, and genetic mechanisms", pp.2021
  47. Zheng XY, "Research progress on the pharmacological mechanisms of Chinese medicines that tonify Qi and activate blood against cerebral ischemia", reperfusion injury, 2022, pp.8, 225~235
  48. McAlpine PL, "Organosulfur compounds in colorectal cancer prevention and progression", Nutrients, 16, pp.802~ (2024)
  49. Dai J, "Peptide-functionalized, -assembled and-loaded nanoparticles in cancer therapy", Drug Discov. Today, 29, pp.103981~ (2024)
  50. Niu Q, "Danhong injection improves elective percutaneous coronary intervention in UA patients with blood stasis syndrome revealed by perioperative metabolomics", World J. Tradit. Chin. Med, 8, pp.247~256 (2022)
  51. Kalasabail S, "A perspective on the role of microbiome for colorectal cancer treatment", Cancers, 13, pp.4623~ (2021)
  52. Qiu G, "The significance of probiotics in preventing radiotherapy-induced diarrhea in patients with cervical cancer : a systematic review and meta-analysis", Int. J. Surg, 65, pp.61~69 (2019)
  53. Sheng S, "Predicting the 7th day efficacy of acupoint application of Chinese herbs(Xiao Zhong Zhi Tong Tie)in patients with diarrhea-a machine-learning model based on XGBoost algorithm", World J. Tradit. Chin. Med, 8, pp.257~261 (2022)
  54. Charbonneau MR, "Developing a new class of engineered live bacterial therapeutics to treat human diseases", Nat. Commun, 11, pp.1738~ (2020)
  55. Naran K, "Principles of immunotherapy : implications for treatment strategies in cancer and infectious diseases", Front. Microbiol, 9, pp.3158~ (2018)
  56. De Giani A, "Recent trends on biosurfactants with antimicrobial activity produced by bacteria associated with human health : different perspectives on their properties, challenges, and potential applications", Front. Microbiol, 12, pp.655150~ (2021)
  57. Rabbani F, "Cytotoxicity and apoptosis assay of novel cyclomyrsinol diterpenes against breast cancer cell lines", World J. Tradit. Chin. Med, 8, pp.273~277 (2022)
  58. Ling H, "Recent advances in bacteriophage-based therapeutics : insight into the postantibiotic era", Acta Pharm. Sinica B, 12, pp.4348~4364 (2022)
  59. Ma Y, "Metagenome analysis of intestinal bacteria in healthy people, patients with inflammatory bowel disease and colorectal cancer", Front. Cell. Infect. Microbiol, 11, pp.599734~ (2021)
  60. Ebrahimzadeh S, "Colorectal cancer treatment using bacteria : focus on molecular mechanisms", BMC Microbiol, 21, pp.218~ (2021)
  61. Ruan J, "Mechanism and regulation of pyroptosis-mediated in cancer cell death", Chem. Biol. Iinteract, 323, pp.109052~ (2020)
  62. Obeng E, "Apoptosis(programmed cell death)and its signals-A review", Braz. J. Biol, 81, pp.1133~1143 (2020)
  63. Singh P, "Targeting apoptosis in cancer", Curr. Oncol. Rep, 24, pp.273~284 (2022)
  64. Lin L, "Study on quality markers and action mechanisms of inulae flos on antihepatitis through network pharmacology and high-performance liquid chromatography fingerprints", World J. Tradit. Chin. Med, 8, pp.426~435 (2022)
  65. He X, "Nanoscale covalent organic frameworks : from controlled synthesis to cancer therapy", Chem. Commun, 57, pp.12417~12435 (2021)
  66. Martínez-Reyes I, "Cancer metabolism : looking forward", Nat. Rev. Cancer, 21, pp.669~680 (2021)
  67. Raskov H, "Cytotoxic CD8+ T cells in cancer and cancer immunotherapy", Br. J. Cancer, 124, pp.359~367 (2021)
  68. Lei X, "Immune cells within the tumor microenvironment : biological functions and roles in cancer immunotherapy", Cancer Lett, 470, pp.126~133 (2020)
  69. Aslaner H, "Hemogram parameters in fibromyalgia and effects of wet cupping therapy on hemogram parameters", World J. Tradit. Chin. Med, 8, pp.497~501 (2022)
  70. Lazar V, "Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer", Front. Immunol, 9, pp.1830~ (2018)
  71. Hanus M, "Immune system, microbiota, and microbial metabolites : the unresolved triad in colorectal cancer microenvironment", Front. Immunol, 12, pp.612826~ (2021)
  72. Peng L, "The mechanism of Panax notoginseng in the treatment of heart failure based on biological analysis", World J. Tradit. Chin. Med, 8, pp.530~538 (2022)
  73. Liang K, "Genetically engineered Salmonella Typhimurium : recent advances in cancer therapy", Cancer Lett, 448, pp.168~181 (2019)
  74. Li S, "Tumorigenic bacteria in colorectal cancer : mechanisms and treatments", Cancer Biol. Med, 19, pp.147~ (2022)
  75. Wei RL, "New analysis of banxia xiexin decoction and its similar prescriptions in treatise on febrile diseases to explore the universality of the treatment and compatibility principle", World J. Tradit. Chin Med, 8, pp.509~513 (2022)
  76. Liu K, "Near-infrared-absorbing B-N lewis pair-functionalized anthracenes : electronic structure tuning, conformational isomerism, and applications in photothermal cancer therapy", J. Am. Chem. Soc, 144, pp.18908~18917 (2022)
  77. Fionda C, "NK cells and other cytotoxic innate lymphocytes in colorectal cancer progression and metastasis", Int. J. Mol. Sci, 23, pp.7859~ (2022)
  78. Bai Z, "Tumor-infiltrating lymphocytes in colorectal cancer : the fundamental indication and application on immunotherapy", Front. Immunol, 12, pp.808964~ (2022)
  79. Yang M, "Isobaric tag for relative and absolute quantitation-based proteomics for investigating the effect of guasha on lumbar disc herniation in rats", World J. Tradit. Chin. Med, 9, pp.160~166 (2023)
  80. Brown EM, "Gut microbiota regulation of T cells during inflammation and autoimmunity", Ann. Rev. Immunol, 37, pp.599~624 (2019)
  81. Bao XH, "Metabolic characterization of the badagan constitution in mongolian medicine by ultrahigh-performance liquid chromatography", quadrupole time-of-flight mass spectrometry, World J. Tradit. Chin. Med, pp.2022, 8[DOI]
  82. Kalia VC, "Emerging applications of bacteria as antitumor agents", Semin. Cancer Biol, 86, pp.1014~1025 (2022)
  83. Wang T, "TNF-α and IL-6 : the link between immune and bone system", Curr. Drug Targets, 21, pp.213~227 (2020)
  84. Torres W, "Bacteria in cancer therapy : beyond immunostimulation", J. Cancer Metastasis Treat, 4, pp.4~ (2018)
  85. Liu XY, "Application of the data mining algorithm in the clinical guide medical records", World J. Tradit. Chin. Med, 8, pp.548~555 (2022)
  86. Das T, "Focus on Bacterial Biofilms" (2022), BoD-Books on Demand
  87. Vestby LK, "Bacterial biofilm and its role in the pathogenesis of disease", Antibiotics, 9, pp.59~ (2009)
  88. Rodis N, "Resistance mechanisms in bacterial biofilm formations : a review", J. Emerg. Intern. Med, 4, pp.30~ (2024)
  89. Del Pozo JL, "Biofilm-related disease", Expert Rev. Anti Infect. Ther, 16, pp.51~65 (2018)
  90. Ullah A, "Important flavonoids and their role as a therapeutic agent", Molecules, 25, pp.5243~ (2020)
  91. Song S, "The role of bacteria in cancer therapy-enemies in the past, but allies at present", Infect. Agents Cancer, 13, pp.9~ (2018)
  92. Zhao A, "Understanding bacterial biofilms : from definition to treatment strategies", Front. Cell. Infect. Microbiol, 13, pp.1137947~ (2023)
  93. Xing J, "Bacterial driver-passenger model in biofilms : a new mechanism in the development of colorectal cancer", Clin. Transl. Oncol, 24, pp.784~795 (2022)
  94. Tee DW, "Effective common Chinese herbal medicines used in treating chronic cholecystitis with liver-gallbladder dampness-Heat syndrome : a review of clinical studies in the past 10 years", World J. Tradit. Chin Med, 9, pp.8~20 (2023)
  95. Chen L, "The roles and mechanism of m6A RNA methylation regulators in cancer immunity", Biomedicine & Pharmacotherapy, 163, pp.114839~ (2023)[DOI]
  96. Hols P, "Mobilization of microbiota commensals and their bacteriocins for therapeutics", Trends Microbiol, 27, pp.690~702 (2019)
  97. Stewart N, "Bridging glycomics and genomics : new uses of functional genetics in the study of cellular glycosylation", Front. Mol. Biosci, 9, pp.934584~ (2022)
  98. Wu HJ, "Comprehensive analysis of the molecular mechanism for gastric cancer based on competitive endogenous RNA network", World J. Tradit. Chin. Med, 9, pp.29~42 (2023)
  99. Duangkaew, Methawee, "Investigation of cytotoxic activity of full-length and truncated colicin n on human cancer cells", pp.2020
  100. Abdoullahi S, "Potential role of herbal-and bacterial-derived peptides against colorectal cancer", Revista Brasileira de Farmacognosia, 32, pp.673~692 (2022)
  101. Arunmanee W, "Colicin N mediates apoptosis and suppresses integrin-modulated survival in human lung cancer cells", Molecules, 25, pp.816~ (2020)
  102. Han BJ, "Symptom assessment and management in patients with lung cancer undergoing conventional or traditional Chinese medicine care", World J. Tradit. Chin. Med, 9, pp.235~242 (2023)
  103. Buss GP, "Exploring the cytotoxic mechanisms of Pediocin PA-1 towards HeLa and HT29 cells by comparison to known bacteriocins : microcin E492, enterocin heterodimer and Divercin V41", PLoS One, 16, pp.e0251951~ (2021)
  104. Parker JK, "Microcins reveal natural mechanisms of bacterial manipulation to inform therapeutic development", Microbiology, 168, pp.001175~ (2022)
  105. Dicks LM, "Do bacteria provide an alternative to cancer treatment and what role does lactic acid bacteria play?", Microorganisms, 10, pp.1733~ (2022)
  106. Yaghoubi A, "Bacteriotherapy in breast cancer", Int. J. Mol. Sci, 20, pp.5880~ (2019)
  107. Mahanty J, "Potential of essential oils as alternative permeation enhancers for transdermal delivery", World J. Tradit. Chin. Med, 9, pp.258~269 (2023)
  108. Dong X, "Structural characteristics and intestinal flora metabolism mediated immunoregulatory effects of Lactarius deliciosus polysaccharide", Int. J. Biol. Macromol, 278, pp.135063~ (2024)
  109. Alsawaftah N, "Bioluminescence imaging applications in cancer : a comprehensive review", IEEE Rev. Biomed. Eng, 14, pp.307~326 (2020)
  110. Rodrigues R, "Using spore-forming bacteria to treat cancer: recent advancements in clostridial-based therapies", Sci. Rev. Biol, 30 (2023)
  111. Ren J, "Physiochemical characterization and ameliorative effect of rice resistant starch modified by heat-stable α-amylase and glucoamylase on the gut microbial community in T2DM mice", Food Funct, 10, pp.5596~5612 (2024)
  112. Al-Ostoot FH, "Tumor angiogenesis : current challenges and therapeutic opportunities", Cancer Treat. Res. Commun, 28, pp.100422~ (2021)
  113. Nguyen QD, "The Tie2 signaling pathway in retinal vascular diseases : a novel therapeutic target in the eye", Int. J. Retina Vitreous, 6, pp.48~ (2020)
  114. Eelen G, "Basic and therapeutic aspects of angiogenesis updated", Circ. Res, 127, pp.310~329 (2020)
  115. Wong CB, "Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health:Modulation of gut microbiome as the principal action", J. Funct. Foods, 54, pp.506~519 (2019)
  116. Chang K, "Validation and refinement of two interpretable models for coronavirus disease 2019 prognosis prediction", World J. Tradit. Chin. Med, 9, pp.191~200 (2023)
  117. Ruan Y, "Tingli dazao xiefei decoction ameliorates asthma in vivo and in vitro from lung to intestine by modifying NO-CO metabolic disorder mediated inflammation, immune imbalance, cellular barrier damage, oxidative stress and intestinal bacterial disorders", J. Ethnopharmacol, 313, pp.116503~ (2023)
  118. Li DR, "Shenyi capsule prolongs postoperative survival of patients with nonsmall cell lung cancer : a multicenter, randomized, controlled trial", World J. Tradit. Chin. Med, 9, pp.314~321 (2023)
  119. Di Nicolantonio F, "Precision oncology in metastatic colorectal cancer-from biology to medicine", Nat. Rev. Clin. Oncol, 18, pp.506~525 (2021)
  120. Hana HK, "The mechanism of total ginseng extracts in the treatment of lung cancer progression based on network pharmacology and experimental validation", World J. Tradit. Chin. Med, 9, pp.284~296 (2023)
  121. Wang H, "Tumor-associated macrophages(TAMs)in colorectal cancer(CRC) : from mechanism to therapy and prognosis", Int. J. Mol. Sci, 22, pp.8470~ (2021)
  122. Zhang CM, "Characteristics and correlation analysis of negative emotions, quality of life, and Chinese medicine syndromes in patients with lung cancer after surgery : a cross-sectional study", World J. Tradit. Chin. Med, 9, pp.307~313 (2023)
  123. Kumar A, "Current and emerging therapeutic approaches for colorectal cancer : a comprehensive review", World J. Gastrointest. Surg, 15, pp.495~ (2023)
  124. Yin Y, "Advances in the engineering of the gene editing enzymes and the genomes : understanding and handling the off-target effects of CRISPR", Cas9, 2018, pp.14, 456~476
  125. Horodecka K, "CRISPR", Cas9 : principle, applications, and delivery through extracellular vesicles, 2021, pp.22, 6072~
  126. Tan DC, "A preliminary study on anti-colorectal cancer effect and molecular mechanism of Aegiceras corniculatum extract", World J. Tradit. Chin. Med, 9, pp.404~414 (2023)
  127. Gupta D, "CRISPR-Cas9 system : a new-fangled dawn in gene editing", Life Sci, 232, pp.116636~ (2019)
  128. Hu Y, "CRISPR", Cas9 : a powerful tool in colorectal cancer research, 2023, pp.42, 308~
  129. Mukhopadhyay S, "Genome-wide CRISPR screens identify multiple synthetic lethal targets that enhance KRASG12C inhibitor efficacy", Cancer Res, 83, pp.4095~4111 (2023)
  130. Zhao Y, "Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy", Gut, 67, pp.1845~1854 (2018)
  131. Drost J, "Organoids in cancer research", Nat. Rev. Cancer, 18, pp.407~418 (2018)
  132. Roper J, "Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation", Nat. Protoc, 13, pp.217~234 (2018)
  133. Takeda H, "CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes", Proc. Natl. Acad. Sci, 116, pp.15635~11544 (2019)
  134. Bonjoch L, "Approaches to functionally validate candidate genetic variants involved in colorectal cancer predisposition", Mol. Aspects Med, 69, pp.27~40 (2019)
  135. Kantor A, "CRISPR-Cas9 DNA base-editing and prime-editing", Int. J. Mol. Sci, 21, pp.6240~ (2020)
  136. Anzalone AV, "Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing", Nat. Biotechnol, 40, pp.731~740 (2022)
  137. Chen PJ, "Prime editing for precise and highly versatile genome manipulation", Nat. Rev. Genet, 24, pp.161~177 (2023)
  138. Paturi S, "A glimpse of"Dicer Biology"through the structural and functional perspective", Front. Mol. Biosci, 8, pp.643657~ (2021)
  139. Dixit V, "Transcription Factors for Biotic Stress Tolerance in Plants", pp.1~32 (2022), Springer
  140. Alekseenko I, "Step-by-step immune activation for suicide gene therapy reinforcement", Int. J. Mol. Sci, 22, pp.9376~ (2021)
  141. Rim EY, "The Wnt pathway : from signaling mechanisms to synthetic modulators", Ann. Rev. Biochem, 91, pp.571~598 (2022)
  142. Ginsburg I, "Pro-inflammatory agents released by pathogens, dying host cells, and neutrophils act synergistically to destroy host tissues : a working hypothesis", J. Inflamm. Res, 12, pp.35~47 (2019)
  143. Moravej H, "Antimicrobial peptides : features, action, and their resistance mechanisms in bacteria", Microb. Drug Res, 24, pp.747~767 (2018)
  144. Mohan CD, "Bacteria as a treasure house of secondary metabolites with anticancer potential", Semin. Cancer Biol, 86, pp.998~1013 (2022)
  145. Chen M, "Microbe-material hybrids for therapeutic applications", Chem. Soc. Rev, 53, pp.8306~8378 (2024)
  146. Akram F, "CRISPR-Cas9, a promising therapeutic tool for cancer therapy : a review", Protein Peptide Lett, 27, pp.931~944 (2020)
  147. Dalal N, "Omics technologies for improved diagnosis and treatment of colorectal cancer : technical advancement and major perspectives", Biomed. Pharmacother, 131, pp.110648~ (2020)

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