Enhanced Cholesterol-Lowering and Antioxidant Activities of Soymilk by Fermentation with Lactiplantibacillus plantarum KML06
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
This study aimed to evaluate the cholesterol-lowering and antioxidant activities of soymilk fermented with probiotic Lactobacillaceae strains and to investigate the production of related bioactive compounds. Lactiplantibacillus plantarum KML06 (KML06) was selected for the fermentation of soymilk because it has the highest antioxidant, cholesterol-lowering, and β-glucosidase activities among the 10 Lactobacillaceae strains isolated from kimchi. The genomic information of strain KML06 was analyzed. Moreover, soymilk fermented with KML06 was evaluated for growth kinetics, metabolism, and functional characteristics during the fermentation period. The number of viable cells, which was similar to the results of radical scavenging activities and cholesterol assimilation, as well as the amount of soy isoflavone aglycones, daidzein, and genistein, was the highest at 12 h of fermentation. These results indicate that soymilk fermented with KML06 can prevent oxidative stress and cholesterol-related problems through the production of soy isoflavone aglycones.
Abstract
This study aimed to evaluate the cholesterol-lowering and antioxidant activities of soymilk fermented with probiotic Lactobacillaceae strains and to investigate the production of related bioactive compounds. Lactiplantibacillus plantarum KML06 (KML06) was selected for the fermentation of soymilk because it has the highest antioxidant, cholesterol-lowering, and β-glucosidase activities among the 10 Lactobacillaceae strains isolated from kimchi. The genomic information of strain KML06 was analyzed. Moreover, soymilk fermented with KML06 was evaluated for growth kinetics, metabolism, and functional characteristics during the fermentation period. The number of viable cells, which was similar to the results of radical scavenging activities and cholesterol assimilation, as well as the amount of soy isoflavone aglycones, daidzein, and genistein, was the highest at 12 h of fermentation. These results indicate that soymilk fermented with KML06 can prevent oxidative stress and cholesterol-related problems through the production of soy isoflavone aglycones.
참고문헌 (35)
- Aso Y, "Metabolic syndrome accompanied by hypercholesterolemia is strongly associated with proinflammatory state and impairment of fibrinolysis in patients with type 2diabetes: synergistic effects of plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor", Diabetes Care, 28, pp.2211~2216 (2005)
- Chatterjee C, "Soybean bioactive peptides and their functional properties", Nutrients, 10, pp.1211~ (2018)
- Okabe Y, "Higher bioavailability of isoflavones after a single ingestion of aglycone-rich fermented soybeans compared with glucoside-rich non-fermented soybeans in Japanese postmenopausal women", J. Sci. Food Agric, 91, pp.658~663 (2011)
- 송원옥, "Soy Isoflavones as Safe Functional Ingredients", Journal of Medicinal Food, 10(4), pp.571~580 (2007), 한국식품영양과학회
- Xu L, "A systematic, comparative study on the beneficial health components and antioxidant activities of commercially fermented soy products marketed in China", Food Chem, 174, pp.202~213 (2015)
- Izumi T, "Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans", J. Nutr, 130, pp.1695~1699 (2000)
- Rekha CR, "Bioconversion of isoflavone glycosides to aglycones, mineral bioavailability and vitamin B complex in fermented soymilk by probiotic bacteria and yeast", J. Appl. Microbiol, 109, pp.1198~1208 (2010)
- Hati S, "β-Glucosidase activity and bioconversion of isoflavones during fermentation of soymilk", J. Sci. Food Agric, 95, pp.216~220 (2015)
- Yuksekdag Z, "β-Glucosidase activity and bioconversion of isoflavone glycosides to aglycones by potential probiotic bacteria", Int. J. Food Propert, 20, pp.S2878~S2886 (2018)
- Hur SJ, "Effect of fermentation on the antioxidant activity in plant-based foods", Food Chem, 160, pp.346~356 (2014)
- Wang YC, "Antioxidative activities of soymilk fermented with lactic acid bacteria and bifidobacteria", Food Microbiol, 23, pp.128~135 (2006)
- Sarmadi BH, "Antioxidative peptides from food proteins: a review", Peptides, 31, pp.1949~1956 (2010)
- Oh NS, "Preventive effect of fermented Maillard reaction products from milk proteins in cardiovascular health", J. Dairy Sci, 97, pp.3300~3313 (2014)
- Oh NS, "Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces", PLoS One, 13, pp.e0192021~ (2018)
- Fujii J, "Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease", World J. Biol. Chem, 9, pp.1~15 (2018)
- Tomaro-Duchesneau C, "Cholesterol assimilation by Lactobacillus probiotic bacteria: an in vitro investigation", Biomed. Res. Int, 2014, pp.380316~ (2014)
- Li S, "Antioxidant and antibacterial activities of exopolysaccharides from Bifidobacterium bifidum WBIN03 and Lactobacillus plantarum R315", J. Dairy Sci, 97, pp.7334~7343 (2014)
- Xiao Y, "Enhancement of the antioxidant capacity of soy whey by fermentation with Lactobacillus plantarum B1–6", J. Funct. Foods, 12, pp.33~44 (2015)
- Choi EA, "Cholesterol-lowering effects of a putative probiotic strain Lactobacillus plantarum EM isolated from kimchi", Food Sci. Technol, 62, pp.210~217 (2015)
- Church FC, "Spectrophotometric assay using o-phthaldialdehyde for determination of proteolysis in milk and isolated milk proteins", J. Dairy Sci, 66, pp.1219~1227 (1983)
- Zhang YC, "Analysis of isoflavones in soy foods", Curr. Protoc. Food Chem, 10, pp.1~17 (2004)
- Marazza JA, "Aglycone production by Lactobacillus rhamnosus CRL981 during soymilk fermentation", Food Microbiol, 26, pp.333~339 (2009)
- 임애경, "고지혈증 흰쥐에서 비배당체 이소플라본 고함유 대두분말의 혈청 지질 대사 영향과 항산화효과", 한국식품영양과학회지, 37(3), pp.302~308 (2008), 한국식품영양과학회
- Kawakami Y, "Comparison of regulative functions between dietary soy isoflavones aglycone and glucoside on lipid metabolism in rats fed cholesterol", J. Nutr. Biochem, 16, pp.205~212 (2005)
- Soccol CR, "The potential of probiotics: a review", Food Technol. Biotechnol, 48, pp.413~434 (2010)
- Jeun J, "Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL", 6 mice, 2010, pp.26, 321~330
- Min-Tze Liong, "Lactobacillus plantarum DR7 Reduces Cholesterol via Phosphorylation of AMPK That Down-regulated the mRNA Expression of HMG-CoA Reductase", 한국축산식품학회지, 38(2), pp.350~361 (2018), 한국축산식품학회
- Fuentes MC, "Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529in hypercholesterolaemic adults", Br. J. Nutr, 109, pp.1866~1872 (2013)
- Sanjukta S, "Production of bioactive peptides during soybean fermentation and their potential health benefits", Trends Food Sci. Technol, 50, pp.1~10 (2016)
- Ramdath DD, "Beyond the cholesterol-lowering effect of soy protein: a review of the effects of dietary soy and its constituents on risk factors for cardiovascular disease", Nutrients, 9, pp.324~ (2017)
- Hong GE, "Fermentation increases isoflavone aglycone contents in black soybean pulp", Asian J. Anim. Vet. Adv, 7, pp.502~511 (2012)
- Zhang H, "Enhanced biotransformation of soybean isoflavone from glycosides to aglycones using solid-state fermentation of soybean with effective microorganisms (EM) strains", J. Food Biochem, 43, pp.e12804~ (2019)
- Amadou I, "Fermented soybean products: some methods, antioxidants compound extraction and their scavenging activity", Asian J. Biochem, 4, pp.68~76 (2009)
- Chen CY, "High-genistin isoflavone supplementation modulated erythrocyte antioxidant enzymes and increased running endurance in rats undergoing one session of exhausting exercise – a pilot study", Pakistan J. Nutr, 1, pp.1~7 (2002)
- Ronis MJ, "Effects of soy containing diet and isoflavones on cytochrome P450 enzyme expression and activity", Drug Metab. Rev, 48, pp.331~341 (2016)
