유전자 질병 관련도 분석을 위한 소프트웨어 플랫폼
Software Platform for Analyzing Gene and Disease Relevance
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초록
많은 질병들이 정복되면서 삶의 질을 향상시키지만, 유전병들은 많은 분석 및 연구가 필요하다. 이러한 질병과 유전자 관련도를 분석할 때 다양한 요구사항이 존재하고, 알고리즘 최적화 유무로 인해 런타임 효율성이 저하된다. 본 논문은 유전자 질병 관련도 분석 플랫폼을 소개하고 위의 이슈를 해결하기 위한 분석 API와 두가지 런타임 효율성 최적화 알고리즘을 제시한다. 그리고 제시한 분석 API를 이용하여 관련도 측정 실험을 진행, 두 최적화 알고리즘의 결과와 비교했다. 첫 번째 알고리즘은 이전 실험과 같은 결과를 적은 시간에 도출했고, 두 번째 알고리즘은 이전 실험들에 비해 낮은 정확도의 결과를 더 적은 시간에 도출했다. 따라서 본 플랫폼을 통해 여러 방식의 유전자와 질병 관련도를 효율적으로 얻을 수 있다.
Abstract
While the quality of life is enhanced as many types of diseases are remedied, there is a high demand for analysis and research on gene-related diseases. There exists various forms and requirements in analyzing the relevance between genes and diseases, and the runtime efficiency can be decreased due to the level of algorithm optimization. This paper proposes a platform for analyzing gene disease relevance, provides API for remedying the variability issue, and suggests two algorithms which optimize the runtime efficiency. And, we conduct experiments for measuring the relevancy using the analysis API, and compare the two algorithms. The first algorithm is to improve the runtime efficiency comparing to the conventional methods, and the second algorithm is to improve the runtime efficiency with lower accuracy. This platform can be well utilized for analyzing various forms of gene disease analytics.
참고문헌 (29)
- 김만선, "동적인 개념을 적용한 알츠하이머 질병 네트워크의 특성분석", 한국지능시스템학회 논문지, 25(6), pp.529~535 (2015), 한국지능시스템학회
- Kai Zheng, "Diagnosis of kashin-beck disease and other common joint diseases via a gene model", Proceedings of IEEE 2nd Information Technology, Networking, Electronic and Automation Control Conference (ITNEC 2017), pp.808~812 (2017)
- Gui-Qiong Zhu, "Identifying the candidate genes for Alzheimer's disease based on the rejection region of T test", International Conference on Machine Learning and Cybernetics (ICMLC 2016), 2, pp.732~736 (2016)
- Rohit Gupta, "Identification of gene network motifs for cancer disease diagnosis", Proceedings of IEEE Distributed Computing, VLSI, Electrical Circuits and Robotics (DISCOVER 2016), pp.179~184 (2016)
- Jahnabi Dutta, "Identification of disease-critical genes causing preeclampsia:Meta-heuristic approaches", Proceedings of IEEE UP Section Conference on Electrical Computer and Electronics (UPCON 2015), pp.1~6 (2015)
- 하지환, "타겟 유전자 기반 miRNA 네트워크를 통한 질병 관련 miRNA 추출 방법", 한국정보기술학회논문지, 13(1), pp.113~119 (2015), 한국정보기술학회[DOI]
- Jong-Keun Lee, "Development of a Gene's Functional Classifying System for a Microarray Data using a Gene Ontology", Journal of Korea Information Science Society, 33(2C), pp.246~251 (2006)
- Xiwei Tang, "A algorithm for identifying disease genes by incorporating the subcellular localization information into the protein-protein interaction networks", Proceedings of IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2016), pp.308~311 (2016)
- Shadi A. Aljawarneh, "Gene profile classification: A proposed solution for predicting possible diseases and initial results", Proceedings of International Conference on Engineering &MIS (ICEMIS 2016), pp.1~7 (2016)
- Shadi A. Aljawarneh, "Gene profile classification A proposed solution for predicting possible diseases and initial results", Proceedings of IEEE Engineering & MIS (ICEMIS 2016), pp.1~7 (2016)
- Amirhossein Tavanaei, "A deep learning model for predicting tumor suppressor genes and oncogenes from PDB structure", Proceedings of Bioinformatics and Biomedicine (BIBM 2017), pp.613~617 (2017)
- TengJiao Wang, "Predicting potential disease-related genes using the network topological features", Proceedings of Human Health and Biomedical Engineering (HHBE 2011), pp.871~876 (2011)
- Mustafa Özgür Cingiz, "The inference of gene co-expression networks of breast and colon cancer using miRNA-target gene interactions data", Proceedings of Signal Processing and Communications Applications Conference (SIU 2017), pp.1~4 (2017)
- Ashkan Entezari Heravi, "A methodology for disease gene association using centrality measures", Proceedings of IEEE Congress on Evolutionary Computation (CEC 2016), pp.24~31 (2016)
- Ashwani Kumar, "Systems biology approach for gene set enrichment and topological analysis of Alzheimer's disease pathway", Proceedings of International Conference on Bioinformatics and Systems Biology (BSB 2016), pp.1~5 (2016)
- Nivit Grewal, "Effect of Aggregation Operators on Network-Based Disease Gene Prioritization: A Case Study on Blood Disorders", IEEE, 2016, pp.14(6), 1276~1287
- Kazutaka Nishiwaki, "Finding a disease-related gene from microarray data using random forest", Proceedings of Cognitive Informatics & Cognitive Computing (ICCI*CC 2017), pp.542~546 (2017)
- Khalid M.O. Nahar, "Information analysis to study interactions between different genes and diseases", Proceedings of 8th International Conference on Information Technology (ICIT 2017), pp.1~5 (2017)
- Zhen Tian, "Constructing an integrated gene similarity network for the identification of disease genes", Proceedings of IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2016), pp.1663~1668 (2016)
- Kyungsik Ha, "Integrated Model design of miRNA, PPI and Disease Information", Journal of Korea Information Science Society, 39(1B), pp.492~494 (2012)
- 하경식, "miRNA, PPI, 질병 정보를 이용한 마이크로어레이 데이터 통합 모델 설계", 한국지능시스템학회 논문지, 22(6), pp.786~792 (2012), 한국지능시스템학회
- Jeongwoo Kim, "ISN: Inferring disease-related genes using seed gene and network analysis", Proceedings of IEEE International Conference on Systems, Man, and Cybernetics (SMC 2017), pp.2012~2017 (2017)
- 김태영, "핀 배열 안테나를 단위 안테나로 사용한 선형 위상 배열 안테나의 방사 특성", 전자공학회논문지 - TC, 46(12), pp.44~51 (2009), 대한전자공학회
- Kai Zheng, "Application of a gene diagnosis model in the identification of Kashin-Beck disease and similar joint diseases", Proceedings of IEEE International Conference on Computer and Communications (ICCC 2017), pp.2669~2673 (2017)
- Pradipta Maji, "Significance and Functional Similarity for Identification of Disease Genes", IEEE, 2016, pp.14(16), 1419~1433
- Hyung-Seok Choi, "Systematic Integrative Analysis of Heterogeneous Bio Big Data for Identification of Diseasecausing Gene Network", Journal of Korea Information Science Society, 31(5), pp.61~68 (2013)
- Mengmeng Wu, "Integrating embeddings of multiple gene networks to prioritize complex disease-associated genes", Proceedings of IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2017), pp.208~215 (2017)
- 최선욱, "유전자 상호작용 정보와 mRMR 필터 기반의 Random Subspace Method를 이용한 질병 진단", 한국지능시스템학회 논문지, 22(2), pp.192~197 (2012), 한국지능시스템학회[DOI]
- 임채균, "맵리듀스를 이용한 효율적인 병렬 유전자 선택 기법", 정보과학회논문지 : 데이타베이스, 41(3), pp.162~167 (2014), 한국정보과학회
